With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28418-88-4,4-Iodoisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.
To the beaker 1 was added 10.0 g of 1.1-dimethyl-2-methylthioethylamine (0.084 mol) and 15.6 g at 20-35 C.Acetone; 17.7 g of 3-iodophthalic anhydride (0.065 mol) and 70 g of acetone were added to beaker 2, and stirred with a glass rod for 5 minutes.After the clock, the solid is completely dissolved; in the beaker 1, the liquid A is pumped into the mixer by the mechanical pump A, and at the same time, the liquid B in the beaker 2 is also used by the mechanical pump B.Pumped into the mixer, the flow ratio of mechanical pump A to mechanical pump B is 1:3.43 (mass ratio), and the liquid in the mixer enters the operation.In a microchannel reactor with a temperature of 8 C, the retention time in the microchannel reactor was 10 minutes, and the cone was received and discharged.The reaction solution was evaporated under reduced pressure to give a pale yellow solid: 24.3 g, yield: 95.7% (3-iodophthalic anhydrideThe main product content is: 96% (HPLC), the isomer content is 2.6% (HPLC),, 28418-88-4
28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; Changzhou Woteng Chemical Technology Co., Ltd.; Liu Zuhe; Yao Yuan; Lu Wenlong; Cao Li; (7 pag.)CN109574892; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem