With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.
Example 15:Preparation of (S)-2,2-diphenyl-2-{l-[2-(2,3-dihydrobenzofuran-5yl)-ethyl]- pyrrolidin-3yl} acetic acid methyl ester: A mixture of 3-(S)-2,2-diphenyl-2-pyrrolidinyl-3yl-acetic acid methyl ester(29.5 grams), 5-(2-bromoethyl)2,3-dihydrobenzo[2,3-b]furan (22.7 grams), anhydrous potassium carbonate (27.6 grams) and acetonitrile (300 ml) was heated to reflux and stirred for 60 min. The mixture was partitioned between methylene chloride (250 ml) and 10percent aqueous potassium carbonate (250 ml). The two layers were separated and the aqueous layer was extracted with methylene chloride. The organic layer was dried with sodium sulphate and distilled off the organic layer under reduced pressure followed by triturating with ethyl acetate to get the title compound. Yield: 30.5 grams
127264-14-6, As the paragraph descriping shows that 127264-14-6 is playing an increasingly important role.
Reference£º
Patent; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; VENKATESH, Mummadi; WO2008/126106; (2008); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem