Category: benzofuran

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15832-09-4,6-Methoxy-3(2H)-benzofuranone,as a common compound, the synthetic route is as follows.,15832-09-4

Step 4: A mixture of 6-methoxy-benzofuran-3(2H)-one (1.64 g, 10 mmol) and (carboxymethylene)triphenylphosphorane (5.22 g, 15 mmol) was refluxed in toluene (100 ml) for 48 hrs. Afterwards, reaction mixture was concentrated and loaded over a silica-gel column. The column was eluted with hexane (500 ml) and then with 25% ethyl acetate. The product, ethyl(6-methoxy-1-benzofuran-3-yl)acetate, was obtained as a white oil. Yield: 1.8 g (76%); (M+H): 235.

The synthetic route of 15832-09-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Venkatesan, Aranapakam Mudumbai; Santos, Osvaldo Dos; Asselin, Magda; Grosu, George Theodore; Evrard, Deborah A.; Mewshaw, Richard Eric; Meagher, Kristin; US2009/54454; (2009); A1;,
Benzofuran – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133720-60-2,7-Bromobenzofuran,as a common compound, the synthetic route is as follows.,133720-60-2

EXAMPLE 43 cis -3-methyl-4-(benzofur-7-yl)piperidine hydrochloride Beginning with 7 gm (35.5 mMol) 7-bromobenzofuran and 7.9 gm (39 mMol) 1-benzyl-3-methyl-4-oxopiperidine, 1.92 gm (21%) of the title compound were prepared as a white powder essentially as described in EXAMPLE 19. EA: Calculated for C14H17NO-HCl: C, 66.79; H, 7.21; N, 5.56. Found: C, 66.41; H, 7.02; N, 5.70.

The synthetic route of 133720-60-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; EP1204659; (2003); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.,127264-14-6

The compound (3S) -pyrrolidin-3-yl cyclopentyl (hydroxy) phenylacetate (0.2 g, 0.69 MM) was dissolved in acetonitrile (5.0 ml) followed by the addition of 5- (2-bromoethyl)-2, 3- DIHYDRO-1-BENZOFURAN (0.173 g, 0.76 mM), potassium carbonate (0.29 g, 2.01 MM) and potassium iodide (0.23 g, 1.38 mM). The reaction mixture was heated under reflux for 8 hours and then cooled to room temperature. Acetonitrile was evaporated under vacuum. The residue was partitioned between ethyl acetate (30.0 ml) and water (30.0 ml). The organic layer was washed with water and brine solution followed by drying over anhydrous sodium sulphate. The residue was purified by silica get column chromatography using 10percent methanol in chloroform to get the title compound as oil. Yield = 50percent (0. 15 G, 0. 34 MM). 1H NMR (CDCl3) : delta 7.66 (d, J = 7 Hz, 2H), 7.31-7.36 (M, 3H), 7.03 (d, J = 8 Hz, 1H), 6.93 (t, J = 8 Hz, 1H), 6.69-6.72 (M, 1H), 5.22-5.24 (M, 1H), 4.55 (t, J = 9 Hz, 2H), 3.76 (br M, 1H), 3.18 (t, J = 9 Hz, 2H), 2.54-2.92 (M, 8H), 2.00-2.50 (M, 1H), 1.25-1.63 (M, 1 OH, including-OH).

The synthetic route of 127264-14-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RANBAXY LABORATORIES LIMITED; WO2004/56767; (2004); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-12-3,5-Nitrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.,10242-12-3

(d). 5-Nitrobenzofuran. To a 100 mL round-bottomed flask was added 5-nitrobenzo[b]furan-2-carboxylic acid, Example 38(c), (860 mg, 4.2 mmol), copper (830 mg, 13 mmol, Aldrich), and quinoline (38 mL, Aldrich). The reaction flask was placed in a 185 C. oil bath and magnetically stirred for 20 min under N2. After allowing to cool to 25 C., the mixture was filtered through a 1″ pad of Celite. To the filtrate was added 10% aq. HCl (300 mL) and the aqueous layer was extracted with Et2O (3*100 mL). The combined ethereal layers were washed with 10% HCl (4*200 mL, 1*100 mL), satd NaHCO3 (200 mL), and satd NaCl (100 mL), dried over MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (10:0.25 hexanes:EtOAc) provided 5-nitrobenzofuran as a white solid.

The synthetic route of 10242-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bo, Yunxin Y.; Chakrabarti, Partha P.; Chen, Ning; Doherty, Elizabeth M.; Fotsch, Christopher H.; Han, Nianhe; Kelly, Michael G.; Liu, Qingyian; Norman, Mark Henry; Ognyanov, Vassil I.; Wang, Xianghong; Zhu, Jiawang; US2003/195201; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

90843-31-5, 5-Acetyl-2,3-dihydrobenzo[b]furan is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,90843-31-5

General procedure: The target thiosemicarbazones were prepared by dissolving corresponding ketone (2a-b) (0.005 mol) and appropriate thiosemicarbazide (1a-q) (0.005 mol) in ethanol containing 1-2 drops of HCl as catalyst. The reaction mixture was heated under reflux at 80 C for 2-3 h and course of the reaction was monitored by TLC. After the reaction completion,the excess solvent was evaporated under vacuum and the crystalline or amorphous product formed was filtered, washed with hot ethanol and then with diethyl ether to afford the required thiosemicarbazones (3a-u) in excellent yields. The synthesized thiosemicarbazones were further recrystallized by mixture of chloroform-ethanol (1:1). For X-ray measurements, single crystal of 3m was mounted on a MiTeGen loop with grease and examined on a Bruker D8 Venture APEX diffractometer equipped with Photon 100 CCD area detector and Oxford Cryostream cooler at 296 (2) K using graphite-monochromated Mo-Kalpharadiation (lambda=0.71073 A). Data was collected using the APEX-II software [33], integrated using SAINT [34] and corrected for absorption using a multi-scan approach (SADABS) [35]. The structure was solved using intrinsic phasing (SHELXT) [36]. Final cell constants were determined from full least squares refinement of all observed reflections. All non-H atoms were located in subsequent difference maps and refined anisotropically with SHELXL-97 [37], using full least squares refinement against F2. H-atoms were added at calculated positions and refined with a riding model. The structure has been deposited with the CCDC (CSD deposition numbers 1874544).

As the paragraph descriping shows that 90843-31-5 is playing an increasingly important role.

Reference£º
Article; Islam, Muhammad; Khan, Ajmal; Shehzad, Muhammad Tariq; Hameed, Abdul; Ahmed, Nadeem; Halim, Sobia Ahsan; Khiat, Mohammed; Anwar, Muhammad Usman; Hussain, Javid; Csuk, Rene; Shafiq, Zahid; Al-Harrasi, Ahmed; Bioorganic Chemistry; vol. 87; (2019); p. 155 – 162;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84594-78-5,6-Nitro-2,3-dihydrobenzofuran-5-amine,as a common compound, the synthetic route is as follows.,84594-78-5

A suspension of 6-nitro-2,3-dihydrobenzofuran-5-amine [CAS 84594-78-5] (135.00g, 749.33 mmol) in concentrated HCI (250 mL) was heated to 100C for 10 mm.The solution was cooled to 0C. A solution of NaNO2 (62.04 g, 899.20 mmol) inH20 (250 mL) was added dropwise. The reaction mixture was stirred for 30 mm at0C. The reaction mixture was added slowly to a cooled (0C) solution of KI(186.58 g, 1.12 mol) in H20 (250 mL). The resulting mixture was heated to 70C for 2 h. After cooling to room temperature, H20 (2 L) was added and the crude product was extracted with EtOAc (2x 2 L). The combined organic phases were washed with aqueous HCI (10%, 1 L), aqueous NaOH (1 N, 1 L), a saturated aqueous Na2SO3 solution (1 L) and brine (1 L). After drying over MgSO4, the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: petroleum ether/EtOAc 8/1) to give5-iodo-6-nitro-2,3-dihydrobenzofuran 7a (90.00 g) as a pale yellow solid.

As the paragraph descriping shows that 84594-78-5 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICALS, INC.; KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothee Alice Marie-Eve; BONFANTI, Jean-Francois; COESEMANS, Erwin; KESTELEYN, Bart Rudolf Romanie; MARCHAND, Arnaud Didier M; RABOISSON, Pierre Jean-Marie Bernard; (96 pag.)WO2017/167952; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

69999-16-2, 2,3-Dihydrobenzofuranyl-5-acetic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,69999-16-2

(A) Preparation of 5-(2-hydroxyethyl)-2,3-dihydrobenzofuran STR76 A solution of (2,3-dihydrobenzofuran-5-yl)acetic acid (4.9 g — see EP-A-132130) in anhydrous tetrahydrofuran (50 ml) was added over 10 minutes, dropwise, to a stirred suspension of lithium aluminium hydride (1.57 g) in anhydrous tetrahydrofuran (50 ml) at 0. The mixture was allowed to warm to room temperature and stirred for 1 hour. Water (1.5 ml) was then added dropwise with caution followed by 10% aqueous sodium hydroxide (1.5 ml) and, finally, water (4.5 ml). The mixture was filtered and the inorganic salts washed with ethyl acetate (2*50 ml). The filtrate and washings were combined and concentrated in vacuo to give the title compound as an oil, yield 3.3 g. 1 H N.M.R. (CDCl3) delta=7.10 (s, 1H); 7.00 (d, 1H); 6.75 (m, 1H); 4.65-4.55 (m, 2H); 3.90-3.75 (m, 2H); 3.30-3.15 (m, 2H); 2.90-2.80 (m, 2H); 1.85-1.75 (brs, 1H) ppm.

The synthetic route of 69999-16-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc.; US5192765; (1993); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

652-39-1, 4-Fluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,652-39-1

In a 50 ml flask was placed 3-Fluorophthalic anhydride (1.0 g, 6 mmol) and aqueous NH3 (1.6 g, 24 mmol). The mixture was heated to 280 0C within 30 minutes and then the flask was cooled to room temperature. 0.93 g of compound 13 were isolated as a yellow solid. LC-MS (ESI, positive): 166 [M+H]+.

The synthetic route of 652-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PHENOMIX CORPORATION; WO2008/86161; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

610-93-5, 6-Nitroisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,610-93-5

General procedure: The catalytic reduction of nitro aromatics was conducted in a 25 mlTelfon-lined stainless steel autoclave with magnetic stirring. In a typicalprocess, 6 mmol nitroarene, and desired amounts of reducing agent andsolvents were introduced in the reactor. The autoclave was transferredinto a water bath at the set temperature with an accuracy of better than0.2 C for ?0.5 h. Then, 10 mg catalyst was added into the reactionmixture and started the reduction at a stirring rate of 450 rpm. After thereaction, the catalyst was rapidly separated by ltration. n-Decane(500 muL) as standard was added into the ltrate and was dried withanhydrous Na 2 SO 4 . The products were analyzed by gas chromato-graphy-mass spectrometry (GC-MS) (Shimadzu GCMS-QP2010 Plus)and GC (Varian CP-3800) with a capillary column (column VF-1 ms,15 m, 0.25 mm, 0.25 mum) and a ame ionization detector (FID).

The synthetic route of 610-93-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Huang, Haigen; Liang, Xiangcheng; Wang, Xueguang; Sheng, Yao; Chen, Chenju; Zou, Xiujing; Lu, Xionggang; Applied Catalysis A: General; vol. 559; (2018); p. 127 – 137;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58546-89-7,Benzofuran-5-amine,as a common compound, the synthetic route is as follows.,58546-89-7

To a suspension of 7-chloro-3-(4-fluorophenyl)pyrazolo[ 1 ,5-a]pyrimidine (350 mg, 1.42 mmol) in anhydrous acetonitrile (10 mL), was added DIPEA (740 muL, 4.25 mmol) and benzofuran-5 -amine (270 mg, 2.03 mmol). The mixture was stirred at 170 0C for 3 x 15 minutes, under microwave activation, then cooled to room temperature. Upon cooling a crystalline solid precipitated, this solid was filtered, washed with acetonitrile and dried in vacuo, giving 320 mg (66 %) of the title compound. LC-MS RT= 2.36 min, MH+ = 345.2. 1H NMR (de-DMSO): 10.15 (IH, s), 8.78 (IH, s), 8.30-8.23 (3H, m), 8.10 (IH, d, J2.2), 7.77 (IH, d, J2.2), 7.73 (IH, d, J 8.6), 7.43 (IH, dd, J 8.6 &; 2.2), 7.28 (2H, t, J 9.0), 7.04 (IH, d, J2.3), 6.25 (IH, d, J5.2).

The synthetic route of 58546-89-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BioMarin IGA, Ltd.; WREN, Stephen Paul; WYNNE, Graham Michael; LECCI, Cristina; WILSON, Francis Xavier; WO2010/86040; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem