With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58546-89-7,Benzofuran-5-amine,as a common compound, the synthetic route is as follows.,58546-89-7
To a suspension of 7-chloro-3-(4-fluorophenyl)pyrazolo[ 1 ,5-a]pyrimidine (350 mg, 1.42 mmol) in anhydrous acetonitrile (10 mL), was added DIPEA (740 muL, 4.25 mmol) and benzofuran-5 -amine (270 mg, 2.03 mmol). The mixture was stirred at 170 0C for 3 x 15 minutes, under microwave activation, then cooled to room temperature. Upon cooling a crystalline solid precipitated, this solid was filtered, washed with acetonitrile and dried in vacuo, giving 320 mg (66 %) of the title compound. LC-MS RT= 2.36 min, MH+ = 345.2. 1H NMR (de-DMSO): 10.15 (IH, s), 8.78 (IH, s), 8.30-8.23 (3H, m), 8.10 (IH, d, J2.2), 7.77 (IH, d, J2.2), 7.73 (IH, d, J 8.6), 7.43 (IH, dd, J 8.6 &; 2.2), 7.28 (2H, t, J 9.0), 7.04 (IH, d, J2.3), 6.25 (IH, d, J5.2).
The synthetic route of 58546-89-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BioMarin IGA, Ltd.; WREN, Stephen Paul; WYNNE, Graham Michael; LECCI, Cristina; WILSON, Francis Xavier; WO2010/86040; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem