Day: October 26, 2022

Saxena, Paridhi; Maida, Neha; Kapur, Manmohan published an article in 2019, the title of the article was Dioxazolones as masked ester surrogates in the Pd(II)-catalyzed direct C-H arylation of 6,5-fused heterocycles.Formula: C8H5IO And the article contains the following content:

A simple and effective Pd(II)-catalyzed regioselective C(2)-H arylation of 6,5-fused heterocycles with dioxazolones as a masked ester surrogate under mild conditions was reported. The significance of the arylation was highlighted by the new reactivity demonstrated in dioxazolones via proximal C-H activation of the cyclic carbonate of the hydroxamic acid functionality under protic conditions. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Formula: C8H5IO

The Article related to dioxazolonyl benzene benzofuran alkanol palladium catalyst regioselective arylation, benzofuranyl benzoate preparation, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenothiophenes and other aspects.Formula: C8H5IO

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On February 20, 2003, Gerlach, Matthias; Przewosny, Michael; Englberger, Werner Guenter; Reissmueller, Elke; Bloms-Funke, Petra; Maul, Corinna; Jagusch, Utz-Peter published a patent.Name: 5-Iodobenzofuran The title of the patent was Preparation of 5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzo[c]fluoren-6-carboxylic acids as NMDA antagonists for the treatment of pain. And the patent contained the following:

Title compounds I [R1, R2, R3, R4 = H, halo, CN, etc.; R5 = H, alkyl, alkenyl, etc.; R6 = R12, ZR12; R12 = H, alkyl, alkenyl, etc.; Z = (un)substituted alkyl, alkenyl, alkynyl; R7, R8, R9, R10 = H, halo, CN, etc.] and their pharmaceutically acceptable salts were prepared For example, acid catalyzed three-component coupling of benzofuran, oxoacetic acid and 3,5-dichlorobenzenamine provided claimed benzo[c]fluorene II (no data provided). In glycine binding site studies of the NMDA receptor channel, one specific example of compound I, benzo[c]fluorene II exhibited a Ki = 0.053 μM. Compounds I are claimed useful as analgesic agents for the treatment of pain. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Name: 5-Iodobenzofuran

The Article related to preparation benzofluorenecarboxylic acid analgesic agent pain, benzofluorenecarboxylic acid preparation nmda antagonist glutamate receptor, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Name: 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On February 2, 2021, Chen, Haifeng; Ye, Zhonghua; Zhang, Zhaochao; Li, Chong published a patent.COA of Formula: C8H5IO The title of the patent was Preparation of benzoxazole or benzothiazole derivatives containing carbazole structure for organic light emitting devices. And the patent contained the following:

The invention relates to the preparation of benzoxazole or benzothiazole derivatives with general formula I containing carbazole structure for organic electroluminescent devices [where L1, L2, L3 = single bond, substituted or unsubstituted C6-C30 arylene, substituted or unsubstituted C2-C30 heteroarylene; X = O or S; R1 = substituted or unsubstituted 5-60 membered heteroaryl containing one or more heteroatoms], which has the following advantages: high glass transition temperature, low evaporation temperature, good thermal stability, low extinction coefficient, high refractive index, high luminous efficiency, and low energy consumption. For example, 2,2′-(9-(4-(benzo[d]oxazol-2-yl)phenyl)-9H-carbazole-3,6-diyl)bis(benzo[d]oxazole) was prepared by condensation reaction of 3,6-dibromo-9H-carbazole with 2-(4-iodophenyl)benzo[d]oxazole, and then condensation reaction with benzo[d]oxazole. The title compounds can be used to prepare organic light emitting devices. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).COA of Formula: C8H5IO

The Article related to condensation suzuki coupling preparation benzoxazole benzothiazole carbazole oled, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C8H5IO

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On February 4, 2020, Mao, Jianyou; Ling, Bo; Yang, Wenjun published a patent.Name: 5-Iodobenzofuran The title of the patent was Synthetic method of β,β-disubstituted propionate derivatives from aldehyde, iodide and alcohol by one-pot process. And the patent contained the following:

The invention is related to the synthetic method of β,β-disubstituted propionate derivatives from aldehyde, iodide and alc. by one-pot process. The title method includes subjecting aldehyde (cinnamaldehyde, 3-(4-chloro-phenyl)-propenal, etc.), iodide (iodobenzene, 4-tert-butyliodobenzene, etc.) and alc. (methanol, etc.) to a one-pot process in the presence of catalyst (N-heterocyclic carbene catalysts (1,3-bis(2, 6-diisopropylphenyl)imidazolium chloride, 1,3-dicyclohexyl-imidazolium chloride, etc.) and transition metal catalysts (tetrakis(triphenylphosphine)palladium, palladium acetate, etc.)), strong base (potassium methoxide, cesium carbonate, etc.) and ligand (2,2′:6′,2”-terpyridine, L6, etc.) to obtain the β,β-disubstituted propionate derivatives (Me 3,3-diphenylpropionate, Me 3-naphthalen-1-yl-3-phenyl-propionate, etc.). The method realizes the arylation of β-position and the esterification of carbonyl of α,β-unsaturated aldehydes to synthesize Me β,β-disubstituted propionate. The method reduces the synthetic steps of the conventional process, improves the reaction yield, has the advantages of cheap raw materials, simple operation steps and mild reaction conditions, and greatly enriches the applicability of the substrate for the reaction. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Name: 5-Iodobenzofuran

The Article related to synthetic disubstituted propionate derivative aldehyde iodide alc, Aliphatic Compounds: Esters, Linear Anhydrides, Acyl Peroxides, and Acyl Halides and other aspects.Name: 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On October 31, 2018, Wang, Xuan; Ma, Guobin; Peng, Yu; Pitsch, Chloe E.; Moll, Brenda J.; Ly, Thu D.; Wang, Xiaotai; Gong, Hegui published an article.Product Details of 60770-67-4 The title of the article was Ni-Catalyzed Reductive Coupling of Electron-Rich Aryl Iodides with Tertiary Alkyl Halides. And the article contained the following:

This work illustrates the reductive coupling of electron-rich aryl halides with tertiary alkyl halides under Ni-catalyzed cross-electrophile coupling conditions, which offers an efficient protocol for the construction of all carbon quaternary stereogenic centers. The mild and easy-to-operate reaction tolerates a wide range of functional groups. The utility of this method is manifested by the preparation of cyclotryptamine derivatives, wherein successful incorporation of 7-indolyl moieties is of particular interest as numerous naturally occurring products are composed of these key scaffolds. DFT calculations have been carried out to investigate the proposed radical chain and double oxidative addition pathways, which provide useful mechanistic insights into the part of the reaction that takes place in solution The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Product Details of 60770-67-4

The Article related to all carbon quaternary stereogenic center synthesis, reductive coupling electron rich haloarene tertiary alkyl halide mechanism, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Product Details of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On July 26, 2021, Boehm, Philip; Martini, Tristano; Lee, Yong Ho; Cacherat, Bastien; Morandi, Bill published an article.Recommanded Product: 5-Iodobenzofuran The title of the article was Palladium-Catalyzed Decarbonylative Iodination of Aryl Carboxylic Acids Enabled by Ligand-Assisted Halide Exchange. And the article contained the following:

An efficient and broadly applicable palladium-catalyzed iodination of inexpensive and abundant aryl and vinyl carboxylic acids via in situ activation to the acid chloride and formation of a phosphonium salt is reported. The use of 1-iodobutane as iodide source in combination with a base and a deoxychlorinating reagent gives access to a wide range of aryl and vinyl iodides under Pd/Xantphos catalysis, including complex drug-like scaffolds. Stoichiometric experiments and kinetic anal. suggest a unique mechanism involving C-P reductive elimination to form the Xantphos phosphonium chloride, which subsequently initiates an unusual halogen exchange by outer sphere nucleophilic substitution. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Recommanded Product: 5-Iodobenzofuran

The Article related to aryl vinyl carboxylic acid decarbonylative iodination palladium catalyst, iodination, ligand non-innocence, palladium, reaction mechanism, shuttle catalysis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Recommanded Product: 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On September 25, 2014, Smith, Nicholas D.; Govek, Steven P.; Kahraman, Mehmet; Bonnefous, Celine; Julien, Jackaline D. published a patent.Name: 5-Iodobenzofuran The title of the patent was Polycyclic estrogen receptor modulators and uses thereof. And the patent contained the following:

The invention relates to estrogen receptor modulators (e.g., I) and their pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical preparations comprising them, and their use in the treatment of diseases or conditions that are mediated or dependent upon estrogen receptors. For instance, the invention compound I was prepared and gave a MCF7 inhibition IC50 value of ≤100nM in breast cancer cell ER-α in cell western assay. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Name: 5-Iodobenzofuran

The Article related to estrogen receptor modulator preparation antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Name: 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On December 16, 2021, Andrews, Mark; Soerensen, Morten Dahl; Larsen, Mogens; Devaux, Nicolas; Barros Ribeiro da Silva, Vicinius; Perron, Quentin; Liang, Xifu; Seitzberg, Jimmi Gerner published a patent.Recommanded Product: 29735-85-1 The title of the patent was N-Heteroaryl and N-aryl amidoamides as small molecule modulators of IL-17 and their preparation. And the patent contained the following:

The invention relates to a compound according to formula I and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments. Compounds of formula I wherein X, Y, Z and V are independently N, CH and CR4; R1 is (un)substituted C1-4 alkyl, (un)substituted C3-7 cycloalkyl, C1-6 alkoxy, (un)substituted Ph, etc.; R2 is (un)substituted 5- to 6-membered heteroaryl; R3 is CHR5R6, (un)substituted C3-10 cycloalkyl, (un)substituted tetrahydronaphthyl, etc.; R4 is (un)substituted C1-6 alkyl, (un)substituted C1-6 alkoxy, OH, NH2 and halo; R5 and R6 are independently H, (un)substituted Ph, (un)substituted C1-6 alkyl, (un)substituted C3-7 cycloalkyl, etc.; and pharmaceutically acceptable salts, hydrates and solvates thereof, are claimed. Example compound II was prepared by deprotection of N-[(1S)-1-(dicyclopropylmethyl)-2-[[5-[3,5-dimethyl-1-(2-trimethylsilylethoxymethyl)pyrazol-4-yl]-6-fluoro-2-pyridyl]amino]-2-oxo-ethyl]-2-isopropylpyrazole-3-carboxamide. The invention compounds were evaluated for their IL-17 modulatory activity. From the assay, it was determined that compound II exhibited EC50 value of 15 nM. The experimental process involved the reaction of 5-Hydroxybenzofuran-3-carboxylic acid(cas: 29735-85-1).Recommanded Product: 29735-85-1

The Article related to heteroaryl aryl amidoamide preparation il17 modulator, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 29735-85-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On April 30, 2020, Zhang, Yin-Xiang; Xiao, Xuan; Fu, Zhi-Hong; Lin, Jin-Hong; Guo, Yu; Yao, Xu; Cao, Yu-Cai; Du, Ruo-Bing; Zheng, Xing; Xiao, Ji-Chang published an article.Application In Synthesis of 5-Iodobenzofuran The title of the article was Difluorocarbene-Based Cyanation of Aryl Iodides. And the article contained the following:

Herein, a difluorocarbene-based cyanation of aryl iodides promoted by a cheap copper source, Cu(NO3)2·2.5H2O, under an air atm is reported. Difluoromethylene phosphobetaine (Ph3P+CF2CO2-), an easily available and shelf-stable difluorocarbene reagent, and NaNH2 are used as the carbon source and the nitrogen source for the nitrile group, resp. The cyanation protocol is attractive because no toxic reagent is used and performing the reactions under an air atm. is operationally convenient. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Application In Synthesis of 5-Iodobenzofuran

The Article related to aryl nitrile preparation, difluoromethylene phosphabetaine cyanation aryl iodide, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Application In Synthesis of 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Pan, Yingying; Gong, Yuxin; Song, Yanhong; Tong, Weiqi; Gong, Hegui published an article in 2019, the title of the article was Deoxygenative cross-electrophile coupling of benzyl chloroformates with aryl iodides.Electric Literature of 60770-67-4 And the article contains the following content:

This work describes Ni-catalyzed cross-electrophile coupling of benzyl chloroformate derivatives R1CH(R2)OC(O)Cl (R1 = C6H5, 4-FC6H4, 3-CH3C6H4, etc.; R2 = H, Me, butyl) with aryl iodides ArI (Ar = biphenyl-4-yl, naphthalen-1-yl, 3-oxo-2,3-dihydro-1H-inden-5-yl, 1-benzothiophen-5-yl, etc.) that generates a wide range of diaryl methane products R1CH(R2)Ar. The mild reaction conditions merit the C-O bond radical fragmentation of benzyl chloroformates via halide abstraction or a single electron reduction by a Ni catalyst. This work offers a new substrate type for cross-electrophile couplings. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Electric Literature of 60770-67-4

The Article related to diaryl methane preparation, benzyl chloroformate aryl iodide deoxygenative cross electrophile coupling reaction, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Benzocyclopropenes, Benzocyclobutenes, and Indenes and other aspects.Electric Literature of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem