Day: October 26, 2022

Bowen, Johnathan; Slebodnick, Carla; Santos, Webster L. published an article in 2022, the title of the article was Phosphine-catalyzed hydroboration of propiolonitriles: access to (E)-1,2-vinylcyanotrifluoroborate derivatives.Safety of 5-Iodobenzofuran And the article contains the following content:

We report an organocatalytic trans-hydroboration of 3-substituted-propiolonitriles. In the presence of catalytic amounts of tributylphosphine and pinacolborane, regioselective hydroboration of the internal triple bond proceeded in a stereoselective fashion under mild conditions to afford the corresponding (E)-1,2-vinylcyanoborane derivatives The mechanism is proposed to occur through a 1,2-phosphine addition instead of a canonical 1,4-conjugate addition pathway. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Safety of 5-Iodobenzofuran

The Article related to unsaturated nitrile borylated cyanovinyl borate preparation organocatalytic hydroboration propiolonitrile, phosphine organocatalyst hydroboration propiolonitrile preparation vinylborate nitrile derivative and other aspects.Safety of 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Liu, Yong; Xing, Shuya; Zhang, Jing; Liu, Wen; Xu, Yuenian; Zhang, Yan; Yang, Kefang; Yang, Lei; Jiang, Kezhi; Shao, Xinxin published an article in 2022, the title of the article was Construction of diverse C-S/C-Se bonds via nickel catalyzed reductive coupling employing thiosulfonates and a selenosulfonate under mild conditions.Formula: C8H5IO And the article contains the following content:

A nickel-catalyzed reductive cross coupling between organic iodides and thiosulfonates and a selenosulfonate under mild conditions was disclosed. This practical method provides a facile access to a series of unsym. thioethers with low catalyst loading, good functional group tolerance, and excellent chemo-selectivity. Notably, the synthetic applications of the approach feature scaling-up of reactions, late-stage modification of pharmaceuticals, and preparation of various useful targeted compounds, including sulfoximine, bipyridine, and vortioxetine. Primary mechanistic studies showed that a radical pathway was involved. Moreover, diverse C-S/C-Se bond formations were achieved under mild reaction conditions. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Formula: C8H5IO

The Article related to organic iodide thiosulfonate nickel catalyst chemoselective reductive coupling, thioether preparation, selenosulfonate organic iodide nickel catalyst chemoselective reductive coupling, selenoether preparation and other aspects.Formula: C8H5IO

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On August 10, 2020, Fritzemeier, Russell G.; Nekvinda, Jan; Vogels, Christopher M.; Rosenblum, Carol Ann; Slebodnick, Carla; Westcott, Stephen A.; Santos, Webster L. published an article.SDS of cas: 60770-67-4 The title of the article was Organocatalytic trans Phosphinoboration of Internal Alkynes. And the article contained the following:

We report the first trans phosphinoboration of internal alkynes. With an organophosphine catalyst, alkynoate esters and the phosphinoboronate Ph2P-Bpin are efficiently converted into the corresponding trans-α-phosphino-β-boryl acrylate products in moderate to good yield with high regio- and Z-selectivity. This reaction operates under mild conditions and demonstrates good atom economy, requiring only a modest excess of the phosphinoboronate. X-ray crystallog. experiments allowed structural assignment of the unprecedented and densely functionalized (Z)-α-phosphino-β-boryl acrylate products. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).SDS of cas: 60770-67-4

The Article related to organocatalytic stereoselective phosphinoboration internal alkyne regioselective, crystal structure mol phosphino boryl acrylate trans preparation, alkynes, boron, organocatalysis, phosphinoboration, phosphorus and other aspects.SDS of cas: 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yang, Wenjun; Ling, Bo; Hu, Bowen; Yin, Haolin; Mao, Jianyou; Walsh, Patrick J. published an article in 2020, the title of the article was Synergistic N-Heterocyclic Carbene/Palladium-Catalyzed Umpolung 1,4-Addition of Aryl Iodides to Enals.Related Products of 60770-67-4 And the article contains the following content:

An umpolung 1,4-addition of aryl iodides to enals promoted by cooperative (terpy)Pd/NHC catalysis was developed that generates various bioactive β,β-diaryl propanoate derivatives This system is not only the first reported palladium-catalyzed arylation of NHC-bound homoenolates but also expands the scope of NHC-induced umpolung transformations. A diverse array of functional groups such as esters, nitriles, alcs., and heterocycles are tolerated under the mild conditions. This method also circumvents the use of moisture-sensitive organometallic reagents. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Related Products of 60770-67-4

The Article related to synergistic nitrogen heterocyclic carbene palladium catalyzed umpolung addition, diaryl propanoate preparation addition aryl iodide enal, n-heterocyclic carbenes, addition reactions, cooperative catalysis, palladium, umpolung and other aspects.Related Products of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On June 1, 2021, Huang, Mingming; Wu, Zhu; Krebs, Johannes; Friedrich, Alexandra; Luo, Xiaoling; Westcott, Stephen A.; Radius, Udo; Marder, Todd B. published an article.Application of 60770-67-4 The title of the article was Ni-Catalyzed Borylation of Aryl Sulfoxides. And the article contained the following:

A nickel/N-heterocyclic carbene (NHC) catalytic system has been developed for the borylation of aryl sulfoxides with B2(neop)2 (neop=neopentyl glycolato). A wide range of aryl sulfoxides with different electronic and steric properties were converted into the corresponding arylboronic esters in good yields. The regioselective borylation of unsym. diaryl sulfoxides was also feasible leading to borylation of the sterically less encumbered aryl substituent. Competition experiments demonstrated that an electron-deficient aryl moiety reacts preferentially. The origin of the selectivity in the Ni-catalyzed borylation of electronically biased unsym. diaryl sulfoxide lies in the oxidative addition step of the catalytic cycle, as oxidative addition of methoxyphenyl 4-(trifluoromethyl)phenyl sulfoxide to the Ni(0) complex occurs selectively to give the structurally characterized complex trans-[Ni(ICy)2(4-CF3-C6H4){(SO)-4-MeO-C6H4}] 4. For complex 5, the isomer trans-[Ni(ICy)2(C6H5)(OSC6H5)] 5-i was structurally characterized in which the Ph sulfinyl ligand is bound via the oxygen atom to nickel. In solution, the complex trans-[Ni(ICy)2(C6H5)(OSC6H5)] 5-i is in equilibrium with the S-bonded isomer trans-[Ni(ICy)2(C6H5)(SOC6H5)] 5, as shown by NMR spectroscopy. DFT calculations reveal that these isomers are separated by a mere 0.3 kJ/mol (M06/def2-TZVP-level of theory) and connected via a transition state trans-[Ni(ICy)2(C6H5)(η2-{SO}-C6H5)], which lies only 10.8 kcal/mol above 5. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Application of 60770-67-4

The Article related to crystal structure mol nickel heterocyclic carbene preparation optimized dft, nickel catalyzed borylation aryl sulfoxide regioselective substituent steric effect, boron, n-heterocyclic carbenes, borylation, cross-coupling, nickel and other aspects.Application of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wu, Jiang; Liu, Yafei; Lu, Changhui; Shen, Qilong published an article in 2016, the title of the article was Palladium-catalyzed difluoromethylthiolation of heteroaryl bromides, iodides, triflates and aryl iodides.Product Details of 60770-67-4 And the article contains the following content:

Palladium-catalyzed difluoromethylthiolation of heteroaryl halides and triflates under mild conditions was described. A vast range of heteroaryl halides such as pyridyl, quinolinyl, benzothiazolyl, thiophenyl, carbazolyl and pyrazolyl halides could be difluoromethylthiolated efficiently, thus providing medicinal chemists with new tools for their search of new led compounds for drug discovery. Likewise, aryl iodides were difluoromethylthiolated in high yields under a modified reaction condition. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Product Details of 60770-67-4

The Article related to aryl halide diisopropylphenylimidazolidinyl difluoromethylthiosilver palladium catalyst difluoromethylthiolation, heteroaryl triflate diisopropylphenylimidazolidinyl difluoromethylthiosilver palladium catalyst difluoromethylthiolation and other aspects.Product Details of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On March 22, 2012, Smith, Nicholas D.; Kahraman, Mehmet; Govek, Steven P.; Nagasawa, Johnny Y.; Lai, Andiliy G.; Julien, Jackaline D.; Herbert, Mark R.; Bonnefous, Celine; Douglas, Karensa L. published a patent.Computed Properties of 60770-67-4 The title of the patent was Preparation of substituted 3-[4-[1-(1H-indazol-5-yl)-2-phenylvinyl]phenyl]acrylic acid, derivatives and analogs as estrogen receptor modulators. And the patent contained the following:

The invention is related to the preparation of title compounds I [A =indanyl, indenyl, 8-10 membered bicyclic hetercyclic, etc.; B, C = independently Ph, naphthyl, 5-6 membered monocyclic heteroaryl, etc.; R1 = tetrazolyl, pyrrolidinyl, aminocycloalkyl, etc.; R2 = halo, CN, nO2, alkoxy, etc.; R3-4 = independently at each occurrence H, CN, OH, (un)substituted fluoroalkyl, Ph, etc; m, n, p = independently 0-4], their pharmaceutically acceptable salts and N-oxides as estrogen receptor modulators and to pharmaceutical compositions containing them. Thus, (E)-3-[4-[(E)-1-(1H-Indazol-5-yl)-2-phenylbut-1-en-1-yl]phenyl]-2-propenoic acid (II) was prepared via reaction of 5-(1-butyn-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (preparation given) with iodobenzene and (E)-[4-(3-ethoxy-3-oxoprop-1-en-1-yl)phenyl]boronic acid. II displayed an IC50 ≤ 100 nM in the MCF7 viability assay. I may be useful for the treatment of diseases or conditions that are mediated by or dependent upon estrogen receptors such as cancer, central nervous system (CNS) defects, cardiovascular system defects, hematol. system defects, immune and inflammation diseases, susceptibility to infection, metabolic defects, neurol. defects, psychiatric defects and reproductive defects. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Computed Properties of 60770-67-4

The Article related to indazolyl phenylvinylphenylacrylic acid preparation estrogen receptor modulator cancer cardiovascular, quinoxalinyl benzothiazolyl indazolyl triazolopyridinyl oxoisoindolinyl phenylvinylphenylacrylic acid phenylvinylphenylacrylamide preparation and other aspects.Computed Properties of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On September 16, 2022, Chen, Doris; Jones, Elizabeth V.; Williams, Corey W.; Huynh, Tan-Khang N.; McPhail, Tristan C.; France, Stefan published an article.Recommanded Product: 5-Iodobenzofuran The title of the article was Intramolecular, Interrupted Homo-Nazarov Cascade Biscyclizations to Angular (Hetero)Aryl-Fused Polycycles. And the article contained the following:

A SnCl4-catalyzed intramol., interrupted homo-Nazarov cascade biscyclization to access angular (hetero)aryl-fused polycycles was reported. Subsequent decarboxylation of the readily enolizable products afforded the angular products in up to 71% yield over two steps, with the trans-diastereomers as the major products. The cyclopropyl homo-Nazarov cyclization precursors were formed using a scalable and modular synthetic route that, ultimately, offers access to 6,6,6-, 6,6,5-, 6,5,6-, 6,6,5,6-, and 6,6,6,5-fused angular polycyclic products. To showcase the rigor and utility of the method, an 8-step total synthesis of (±)-1-oxoferruginol, an antibacterial aromatic abietane diterpenoid, was disclosed. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Recommanded Product: 5-Iodobenzofuran

The Article related to alkenyl cyclopropyl ketone tin chloride homo nazarov biscyclization decarboxylation, angular polycyclic compound preparation diastereoselective, cation-pi cyclizations, domino reactions, donor-acceptor cyclopropanes, oxyallyl cations, ring-opening cyclizations and other aspects.Recommanded Product: 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On March 31, 2021, Wu, Xiaowei; Dai, Mengdi; Cui, Rongrong; Wang, Yulan; Li, Chunpu; Peng, Xia; Zhao, Jihui; Wang, Bao; Dai, Yang; Feng, Dan; Yang, Tianbiao; Jiang, Hualiang; Geng, Meiyu; Ai, Jing; Zheng, Mingyue; Liu, Hong published an article.Synthetic Route of 53724-96-2 The title of the article was Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors. And the article contained the following:

Fibroblast growth factor receptors (FGFRs) have emerged as promising targets for anticancer therapy. In this study, we synthesized and evaluated the biol. activity of 66 pyrazolo[3,4-d]pyridazinone derivatives Kinase inhibition, cell proliferation, and whole blood stability assays were used to evaluate their activity on FGFR, allowing us to explore structure-activity relationships and thus to gain understanding of the structural requirements to modulate covalent inhibitors′ selectivity and reactivity. Among them, compound 10h exhibited potent enzymic activity against FGFR and remarkably inhibited proliferation of various cancer cells associated with FGFR dysregulation, and suppressed FGFR signaling pathway in cancer cells by the immunoblot anal. Moreover, 10h displayed highly potent antitumor efficacy (TGI = 91.6%, at a dose of 50 mg/kg) in the FGFR1-amplified NCI-H1581 xenograft model. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Synthetic Route of 53724-96-2

The Article related to pyrazolo pyridazinone derivative covalent fgfr inhibitor biol evaluation, pyridazinone derivative covalent fgfr inhibitor biol evaluation sar, antitumor efficacy, btk, brutons tyrosine kinase, cadd, computer-aided drug design, covalent fgfr inhibitors, egfr, epidermal growth factor receptor and other aspects.Synthetic Route of 53724-96-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On February 3, 2005, Cheng, Jie Fei; Nguyen, Bao Ngoc; Liu, Xuewei; Lopaschuk, Gary D.; Dyck, Jason R. published a patent.Product Details of 29735-85-1 The title of the patent was Preparation of heterocyclic compounds useful as malonyl-CoA decarboxylase inhibitors. And the patent contained the following:

The present invention provides methods for the use of compounds I [X1, X2, X3 = O, N, NH, NR5, S, C; R1, R2 = H, halogen, substituted C1-6-alkyl, substituted C1-6-alkenyl, substituted C1-6-alkynyl, alkoxy, (un)substituted Ph, aryl, (un)substituted heteroaryl, NHCONR5R6, COR5, CONR5R6, S(O)nR5, SO2NR5R6; R3, R4 = H, Br, Cl, F, I, OH, OMe, CO2H, CO2R5, CONR5R6, S(O)nR5, SO2NR5R6, substituted C1-6-alkyl, C1-6-alkoxy, (un)substituted Ph, aryl, heteroaryl; R5, R6 = H, (un)substituted C1-6-alkyl, (un)substituted Ph, aryl, heteroaryl], its enantiomers, diastereomers, tautomers, or physiol. acceptable salts or prodrugs, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. Thus, benzofuran I [X1 = CC(:O)NHC6H3(OMe)2-3,4, X2 = CH, X3 = O, R3 = 4-Br, R4 = 6-Br] was prepared from 5-methoxybenzofuran-2-carboxylic acid via regioselective bromination at C(3), decarboxylation, debromination-carboxylation at C(3), O-demethylation, regioselective dibromination and amidation with 3,4-dimethoxyaniline. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. The inhibitory activity of I vs. malonyl-CoA decarboxylase was determined [Ki = 31.6 – 4750.2 μM]. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity. The experimental process involved the reaction of 5-Hydroxybenzofuran-3-carboxylic acid(cas: 29735-85-1).Product Details of 29735-85-1

The Article related to heterocyclic compound preparation malonyl coa decarboxylase inhibitor, cardiovascular disease prophylaxis management treatment heterocyclic compound, diabetes prophylaxis management treatment heterocyclic compound, cancer prophylaxis management treatment heterocyclic compound, obesity prophylaxis management treatment heterocyclic compound and other aspects.Product Details of 29735-85-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem