Day: October 14, 2022

Formula: C20H14OIn 2020 ,《Post-synthetically elaborated BODIPY-based porous organic polymers (POPs) for the photochemical detoxification of a sulfur mustard simulant》 appeared in Journal of the American Chemical Society. The author of the article were Atilgan, Ahmet; Cetin, M. Mustafa; Yu, Jierui; Beldjoudi, Yassine; Liu, Jian; Stern, Charlotte L.; Cetin, Furkan M.; Islamoglu, Timur; Farha, Omar K.; Deria, Pravas; Stoddart, J. Fraser; Hupp, Joseph T.. The article conveys some information:

Designing new materials for the effective detoxification of chem. warfare agents (CWAs) is of current interest given the recent use of CWAs. Although halogenated boron-dipyrromethene derivatives (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene or BDP or BODIPY) at the 2 and 6 positions have been extensively explored as efficient photosensitizers for generating singlet oxygen (1O2) in homogeneous media, their utilization in the design of porous organic polymers (POPs) has remained elusive due to the difficulty of controlling polymerization processes through cross-coupling synthesis pathways. Our approach to overcome these difficulties and prepare halogenated BODIPY-based porous organic polymers (X-BDP-POP where X = Br or I) represents an attractive alternative through post-synthesis modification (PSM) of the parent hydrogenated polymer. Upon synthesis of both the parent polymer, H-BDP-POP, and its post-synthetically modified derivatives, Br-BDP-POP and I-BDP-POP, the BET surface areas of all POPs have been measured and found to be 640, 430, and 400 m2·g-1, resp. In addition, the insertion of heavy halogen atoms at the 2 and 6 positions of the BODIPY unit leads to the quenching of fluorescence (both polymer and solution-phase monomer forms) and the enhancement of phosphorescence (particularly for the iodo versions of the polymers and monomers), as a result of efficient intersystem crossing. The heterogeneous photocatalytic activities of both the parent POP and its derivatives for the detoxification of the sulfur mustard simulant, 2-chloroethyl Et sulfide (CEES), have been examined; the results show a significant enhancement in the generation of singlet oxygen (1O2). Both the bromination and iodination of H-BDP-POP served to shorten by 5-fold of the time needed for the selective and catalytic photo-oxidation of CEES to 2-chloroethyl Et sulfoxide (CEESO). The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Photocatalytic degradation of tetracycline by a novel (CMC)/MIL-101(Fe)/β-CDP composite hydrogel》 was published in Frontiers in Chemistry (Lausanne, Switzerland) in 2020. These research results belong to Zhang, Hui; Zhou, Liang; Li, Jing; Rong, Sijia; Jiang, Jianping; Liu, Shengquan. Computed Properties of C20H14O The article mentions the following:

Herein, we report a novel CM-cellulose (CMC)/MIL-101 (Fe)/poly(β-cyclodextrin) (β-CDP) hydrogel with high photocatalytic activity. β-CDP can significantly enhance the photoactivity of MIL-101(Fe) in the hydrogel prepared by a simple solvothermal method. The structure and property of this composite hydrogel were characterized by Fourier transform IR spectroscopy, X-ray diffraction, SEM, and transmission electron microscopy. Tetracycline was selected as a model pharmaceutical antibiotic to evaluate the photocatalytic activity of the composite hydrogel under visible light irradiation and darkness, resp. This composite hydrogel shows excellent activity for degrading pharmaceutical antibiotics under visible light irradiation The increased photocatalytic activity can be attributed to β -CDP, which acts as a promoter and affords an efficient separation of photogenerated electron-hole pairs of MIL-101(Fe). Moreover, the composite hydrogel is shown to have good water retainability. The hydrogel is inexpensive and shows high photocatalytic activity. Hence, it can be used as an efficient photocatalytic material.1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Xia, Xiang; Wang, Ran; Hu, Yingqi; Liu, Wei Jian; Liu, Ting; Sun, Wen; Fan, Jiangli; Peng, Xiaojun published an article in 2021. The article was titled 《A novel photosensitizer for lipid droplet-location photodynamic therapy》, and you may find the article in Frontiers in Chemistry (Lausanne, Switzerland).Safety of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Lipid droplets (LDs), an extremely important cellular organelle, are responsible for the storage of neutral lipids in multiple biol. processes, which could be a potential target site for photodynamic therapy (PDT) of cancer. Herein, a lipid droplet-targeted photosensitizer (BODSeI) is developed, allowing for fluorescence imaging-guided PDT. Owing to the location of lipid droplets, BODSeI demonstrates enhanced PDT efficiency with an extremely low IC50 value (around 125 nM). Besides, BODSeI shows good biocompatibility and high photostability. Therefore, BODSeI is promising for droplet-location PDT, which may trigger wide interest for exploring the pathway of lipid droplet-location PDT. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Safety of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Safety of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Synthesis of 2-amino-4-(2-benzofuryl)-Δ1-pyrrolines and study of their antiarrhythmic properties》 was written by Maillard, Jacques; Langlois, Michel; Tri, Vo Van; Guillonneau, Claude; Legeai, Jacques; Benharkate, Marguerite; Blozovski, Mladen. Quality Control of 6-Methoxybenzofuran-2-carbaldehyde And the article was included in European Journal of Medicinal Chemistry on August 31 ,1983. The article conveys some information:

2-Ethoxy-1-pyrrolines I (R = furyl, thienyl, benzofuryl, benzothienyl) were converted to amino analogs II (R1 = H, alkyl; R2 = H, alkyl, allyl, propargyl, CH2CH2OH, CH2CH2NMe2, phenethyl, Ph, OMe, OCH2Ph; or NR1R2 = pyrrolidino, morpholino, 4-methyl-1-piperazinyl), which showed antiarrhythmic activity. I (R = 2-benzofuryl) was heated with Me2NH.HCl in EtOH to give II (R = 2-benzofuryl, R1 = R2 = Me) hydrochloride. The results came from multiple reactions, including the reaction of 6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5Quality Control of 6-Methoxybenzofuran-2-carbaldehyde)

6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5) belongs to benzofurans.Quality Control of 6-Methoxybenzofuran-2-carbaldehydeBenzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Madridejos, Jenica Marie L.; Harada, Takaaki; Falcinella, Alexander J.; Small, Thomas D.; Golovko, Vladimir B.; Andersson, Gunther G.; Metha, Gregory F.; Kee, Tak W. published an article in 2021. The article was titled 《Optical Properties of the Atomically Precise C4 Core [Au9(PPh3)8]3+ Cluster Probed by Transient Absorption Spectroscopy and Time-Dependent Density Functional Theory》, and you may find the article in Journal of Physical Chemistry C.Application In Synthesis of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Structural isomerism of [Au9(PPh3)8]3+ has been studied exptl., mostly concerning the symmetry of the Au9 core. Recently, the C4 isomer of [Au9(PPh3)8]3+ has been shown to exist in solution phase while the D2h isomer is present in the solid state [Inorganic Chem.2017, 56, 8319-8325]. In this work, geometric, electronic, and optical properties of C4 [Au9(PPh3)8]3+ are investigated by using the combined second-order d.-functional tight-binding (DFTB2) method and time-dependent d. functional theory (TD-DFT) calculations with spin-orbit coupling. Addnl., the excited-state relaxation dynamics of the [Au9(PPh3)8]3+ cluster in dichloromethane and methanol solutions are studied using femtosecond transient absorption spectroscopy. [Au9(PPh3)8]3+ is optically pumped to different excited states by using 432, 532, and 603 nm light. For all three pump wavelengths, the photoexcitation event induces an excited-state absorption (ESA) band centered at 600 nm with decay time constants of 2.0 and 45 ps, which are attributed to intersystem crossing and nonradiative relaxation of [Au9(PPh3)8]3+, resp. On the other hand, optical pumping of [Au9(PPh3)8]3+ using 432 nm light gives rise to an addnl. ESA band at 900 nm. This band exhibits fast relaxation through internal conversion with a time constant of ~0.3 ps. Our combined computational and exptl. study reveals that the excitation wavelength-dependent relaxation dynamics of the [Au9(PPh3)8]3+ cluster are related to the different electron densities of the excited states of [Au9(PPh3)8]3+, consistent with it possessing mol.-like electronic states. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Application In Synthesis of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 2022,Li, Man Yi; Mi, Le; Meerovich, Gennady; Soe, Thin Wut; Chen, Ting; Than, Ni Ni; Yan, Yi Jia; Chen, Zhi Long published an article in Journal of Cancer Research and Clinical Oncology. The title of the article was 《The biological activities of 5,15-diaryl-10,20-dihalogeno porphyrins for photodynamic therapy》.Recommanded Product: 5471-63-6 The author mentioned the following in the article:

Esophageal cancer is the most common gastrointestinal tumor and is difficult to be eradicated with conventional treatment. Porphyrin-based photosensitizers (PSs) mediated photodynamic therapy (PDT) could kill tumor cells with less damage to normal cells. As the most widely used porphyrin-based photosensitizer in clinics, Photofrin II has excellent anti-tumor effect. However, it has some disadvantages such as weak absorption at near IR region, the complexity of components and prolonged skin photosensitivity. Here series novel 5,15-diaryl-10,20-dihalogeno porphyrin derivatives were afforded and evaluated to develop more effective and safer photosensitizers for tumor therapy. The photophys. properties and singlet oxygen generation rates of 5,15-diaryl-10,20-dihalogeno porphyrins (I1-6, II1-4) were tested. The cytotoxicity of I1-6 and II1-4 were measured by MTT assay. The pathway of cell death was studied by flow cytometry. In vivo photodynamic efficacy of I3 and II2-4 in Eca-109 tumor-bearing BABL/c nude mice were measured and histopathol. anal. were examined 5,15-Diaryl-10,20-dihalogeno porphyrins I1-6 and II1-4 were synthesized. The longest absorption wavelength of these halogenated porphyrins (λmax = 660 nm) displayed a red shift around 30 nm compared to the unhalogenated porphyrins PS1 (λmax = 630 nm). The singlet oxygen generation rates of I1-6 and II1-4 were significantly higher than PS1 and HMME. All PSs mediated PDT showed obvious cytotoxic effect against Eca-109 cells compared to HMME in vitro and in vivo. Among these PSs, II4 exhibited appropriate absorption in the phototherapeutic window, higher 1O2 generation rate (k = 0.0061 s-1), the strongest phototoxicity (IC50 = 0.4 μM), lower dark toxicity, high generation of intracellular ROS in Eca-109 cells and excellent photodynamic anti-tumor efficacy in vivo. Besides, cell necrosis was induced by compound II4 mediated PDT. All new compounds have obvious photodynamic anti-esophageal cancer effects. Among them, the photosensitizer II4 showed excellent efficacy in vitro and in vivo, which has the potential to become a photodynamic anti-tumor drug. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Recommanded Product: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Lu, Bing; Zhang, Zhecheng; Jin, Danni; Yuan, Xiaolei; Wang, Jin; Ding, Yue; Wang, Yang; Yao, Yong published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《A-DAD-A fused-ring small molecule-based nanoparticles for combined photothermal and photodynamic therapy of cancer》.Category: benzofurans The article contains the following contents:

New nanoparticles (Y6 NPs) based on the A-DAD-A fused-ring conjugated small mol. Y6 have been prepared for the combined photothermal and photodynamic therapy of cancer. Y6 NPs show excellent light absorption from 300 to 900 nm, a good photothermal conversion efficiency of 57% and reactive oxygen species generation capability. The high photothermal conversion ability and superior photodynamic activity of Y6 NPs endow them with great potential for cancer therapy. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Category: benzofurans)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HPLC of Formula: 53860-74-5On October 7, 2008 ,《New scaffolds for the design of selective estrogen receptor modulators》 was published in Organic & Biomolecular Chemistry. The article was written by Martin-Santamaria, Sonsoles; Rodriguez, Jose-Juan; de Pascual-Teresa, Sonia; Gordon, Sandra; Bengtsson, Martin; Garrido-Laguna, Ignacio; Rubio-Viqueira, Belen; Lopez-Casas, Pedro P.; Hidalgo, Manuel; de Pascual-Teresa, Beatriz; Ramos, Ana. The article contains the following contents:

In the present work we report the synthesis of four new ER ligands which can be used as scaffolds for the introduction of the basic side chains necessary for antiestrogenic activity. Affinities and agonist/antagonist characterization of the ligands for both ERα and ERβ have been determined in a competitive radioligand assay, and in an in vitro coactivator recruitment functional assay, resp. Mol. modeling techniques have been used in order to rationalize the exptl. results. Compound 2 is reported as a novel ERβ-agonist/ERα-antagonist. Two compounds show an interesting antitumor profile towards two pancreatic cancer cell lines and have been selected for in vivo assays. In addition to this study using 6-Methoxybenzofuran-2-carbaldehyde, there are many other studies that have used 6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5HPLC of Formula: 53860-74-5) was used in this study.

6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5) belongs to benzofurans.HPLC of Formula: 53860-74-5Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The author of 《The Vilsmeier reaction of fully conjugated carbocycles and heterocycles》 were Jones, Gurnos; Stanforth, Stephen P.. And the article was published in Organic Reactions (Hoboken, NJ, United States) in 1997. Formula: C10H8O3 The author mentioned the following in the article:

A review of the article The Vilsmeier reaction of fully conjugated carbocycles and heterocycles. In the experiment, the researchers used 6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5Formula: C10H8O3)

6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5) belongs to benzofurans.Formula: C10H8O3Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Aguilar Suarez, Luis Enrique; de Graaf, Coen; Faraji, Shirin published their research in Physical Chemistry Chemical Physics in 2021. The article was titled 《Influence of the crystal packing in singlet fission: one step beyond the gas phase approximation》.Formula: C20H14O The article contains the following contents:

Singlet fission (SF), a multiexciton generation process, has been proposed as an alternative to enhance the performance of solar cells. The gas phase dimer model has shown its utility to study this process, but it does not always cover all the physics and the effect of the surrounding atoms has to be included in such cases. In this contribution, we explore the influence of crystal packing on the electronic couplings, and on the so-called exciton descriptors and electron-hole correlation plots. We have studied three tetracene dimers extracted from the crystal structure, as well as several dimers and trimers of the α and β polymorphs of 1,3-diphenylisobenzofuran (DPBF). These polymorphs show different SF yields. Our results highlight that the character of the excited states of tetracene depends on both the mutual disposition of mols. and inclusion of the environment. The latter does however not change significantly the interpretation of the SF mechanism in the studied systems. For DPBF, we establish how the excited state anal. is able to pinpoint differences between the polymorphs. We observe strongly bound correlated excitons in the β polymorph which might hinder the formation of the 1TT state and, consequently, explain its low SF yield. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem