Day: October 14, 2022

《Design of nanostructure chitosan hydrogels for carrying zinc phthalocyanine as a photosensitizer and difloxacin as an antibacterial agent》 was published in International Journal of Biological Macromolecules in 2020. These research results belong to Bayat, Fahimeh; Karimi, Ali Reza; Adimi, Tara. Computed Properties of C20H14O The article mentions the following:

Here, we develop homogeneous hydrogel networks containing zinc tetraamino-phthalocyanine (ZnTAPc) as photosensitizer cross-linked with glutaraldehyde. The crosslinking process occurs via imine bond formation by reaction of NH2 groups of ZnTAPc and chitosan with aldehyde groups of the glutaraldehyde. Insertion of ZnTAPc interestingly increases its solubility in water medium. 2.0% and 4% weight/weight of the ZnTAPc were used with respect to chitosan polymer to generate hydrogel photosensitizer. FT-IR and UV-Vis spectroscopy, SEM, and rheol. measurements were applied to evaluate the properties of the prepared hydrogels. Finally, difloxacin HCl was selected as a fluoroquinolone drug for the assessment of the drug release features of the made hydrogels. The difloxacin release was affected by the amount of ZnTAPc and pH medium. The activity of the hydrogels in photosensitizing process was considered by computing the rate of 1,3-diphenylisobenzofuran adsorption reduction as a singlet oxygen chem. quencher. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Luo, Xiangjie; Chi, Xiaoqin; Lin, Yaying; Yang, Zhaoxuan; Lin, Hongyu; Gao, Jinhao published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《A camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations》.Computed Properties of C20H14O The article contains the following contents:

Mitochondria are crucial regulators of the intrinsic pathway of apoptosis. Herein, we report a photosensitizer-conjugated camptothecin (CPT)-based prodrug for combinative chemo-photodynamic treatment of solid tumors with cascade activations. Upon light irradiation, our prodrug can effectively target the mitochondria of cancer cells, generate singlet oxygen to increase the level of reactive oxygen species (ROS) and trigger ROS-responsive release of CPT, which synergistically induce mitochondrial damage and cause the apoptosis of cancer cells, therefore achieving high therapeutic efficacy for solid tumors and minimized adverse effects to normal tissues. Our prodrug holds great promise as a potent and inspiring means for cancer treatment. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wang, Chenyuan; Xiong, Chuxiao; Li, Zhike; Hu, Liefeng; Wei, Jianshuang; Tian, Jian published an article in 2021. The article was titled 《Defect-engineered porphyrinic metal-organic framework nanoparticles for targeted multimodal cancer phototheranostics》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Related Products of 5471-63-6 The information in the text is summarized as follows:

Defect-engineered porphyrinic MOF nanoparticles were fabricated with an in situ one-pot protocol using cypate as the co-ligand and modulator. This multifunctional nanoplatform integrated the photothermal and multimodal imaging properties of cypate with the photodynamic effects of porphyrins, thus achieving targeted multimodal cancer phototheranostics after folic acid modification. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Related Products of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Related Products of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application of 5471-63-6In 2020 ,《The detection sensitivity of commonly used singlet oxygen probes in aqueous environments》 appeared in Journal of Photochemistry and Photobiology, B: Biology. The author of the article were Entradas, Tiago; Waldron, Sarah; Volk, Martin. The article conveys some information:

The sensitivity for singlet oxygen (1O2) of two convenient 1O2 probes, 1,3-diphenylisobenzofuran (DPBF) and 9,10-Anthracenediyl-bis(methylene)dimalonic acid (ABDA), has been investigated in different aqueous environments. Both probes are com. available at reasonable cost and can be used with standard UV-vis spectrometers. Although DPBF is not soluble in neat water and is not specific to the detection of 1O2, it has very high, essentially diffusion-limited, reactivity towards 1O2; it can trap up to 50% of all 1O2 created in alc./water or micellar solution, and even more when replacing H2O by D2O, which makes it highly useful when the process under investigation does not yield much 1O2. On the other hand, ABDA has a much lower reactivity, reacting with only 2% of the singlet oxygen generated in H2O, as well as a smaller extinction coefficient, resulting in a much smaller spectroscopic response, but is soluble in neat water and is specific for 1O2, allowing for discrimination from other reactive oxygen species. The results presented here not only allow a comparative assessment of the usefulness of the two 1O2 probes, but also provide a reference for an accurate absolute quantification of the amount of 1O2 generated in an experiment from the observed absorbance bleach. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application of 5471-63-6) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Application of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 2017,Asian Journal of Organic Chemistry included an article by Reddy, Bhoomireddy Rajendra Prasad; Reddy, Peddiahgari Vasu Govardhana; Shankar, Muthukonda V.; Reddy, Bijivemula N.. Formula: C10H8O3. The article was titled 《CuI Supported on Protonated Trititanate Nanotubes: A Reusable Catalyst for the One-Pot Synthesis of Propargylamines via A3-Coupling》. The information in the text is summarized as follows:

CuI catalysts supported on protonated trititanate nanotubes (CuI/HTNT) were prepared and used as catalysts for the synthesis of propargylamines via A3 (aldehyde, amine and acetylene) coupling under solvent-free conditions. The results revealed that the CuI/HTNT with 5 wt % CuI had the best catalytic activity. The protocol provided access to a wide range of propargylamines in excellent yields (up to 98 %). The prepared catalysts were characterized by TEM, XRD, N2-adsorption desorption, EDS and ICP-MS anal. The catalyst was recovered by centrifugation and reused in further catalytic reactions, its activity remained largely unchanged for five successive runs. The results came from multiple reactions, including the reaction of 6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5Formula: C10H8O3)

6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5) belongs to benzofurans.Formula: C10H8O3Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Computed Properties of C20H14OIn 2022 ,《Near-infrared triggered ropivacaine liposomal gel for adjustable and prolonged local anaesthesia》 was published in International Journal of Pharmaceutics (Amsterdam, Netherlands). The article was written by Hou, Yufei; Meng, Xiangxue; Zhang, Shixin; Sun, Fengying; Liu, Wenhua. The article contains the following contents:

Local analgesics effectively allow patients to relieve postoperative pain and reduce the need for inhaled general anesthetics or opioids. Compared with other similar long-acting local anesthetics, ropivacaine (Rop) is widely used due to its potential to minimize cardiotoxicity. However, the relatively short duration of Rop efficacy, which lasts for several hours after injection, is considered insufficient for long-term acute and chronic pain treatment. At present, repeated injections or indwelling catheters are used to achieve long-term drug delivery, which can easily cause infection and inflammation. To achieve externally controllable analgesia for a prolonged time, we prepared near-IR (NIR)-responsive Rop liposomes (Rop@Lip) containing photosensitizers PdPC(OBu)8 and unsaturated phospholipid DLPC. The particle size of the Rop@Lip was 234.73 ± 5.21 nm, the PDI was 0.42 ± 0.02, and the drug encapsulation rate was 94.62 ± 1.1%. The release of Rop was highly NIR-dependent in vitro and in vivo. To ensure that the liposomes reside around the nerve for an extended period, we next designed an in situ gel with chitosan (CS) and β-sodium glycerophosphate (β-GP) to form a liposomal gel (Lip/Gel). This Lip/Gel composite drug delivery system could be retained in vivo for 10 d, reduce the side effects caused by drug overdose, and prolong the duration of efficacy. In summary, the NIR-responsive Rop composite drug delivery system generated in this paper can effectively solve the shortcomings of traditional local injections, reduce the toxicity and side effects of free Rop, and provide a basis for a light-responsive delivery system of analgesic drugs. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Serain, Alessandra F.; Morosi, Lavinia; Ceruti, Tommaso; Matteo, Cristina; Meroni, Marina; Minatel, Elaine; Zucchetti, Massimo; Salvador, Marcos J. published their research in Journal of Photochemistry and Photobiology, B: Biology in 2021. The article was titled 《Betulinic acid and its spray dried microparticle formulation: In vitro PDT effect against ovarian carcinoma cell line and in vivo plasma and tumor disposition》.Safety of 1,3-Diphenylisobenzofuran The article contains the following contents:

The race against ovarian cancer continue to motivate the research worldwide. It is known that many antitumor drugs have limited penetration into solid tumor tissues due to its microenvironment, thus contributing to their low efficacy. Therapeutic modalities have been exploited to elicit antitumor effects based on microenvironment of tumor, including Photodynamic therapy (PDT). Prospection of natural small mols. and nanotechnol. are important tools in the development of new ways of obtaining photoactive compounds that are biocompatible. The Betulinic acid (BA) has shown potential biol. effect as bioactive drug, but it has low water solubility Thus, in the present study, owing to the poor solubility of the BA, its free form (BAF) was compared to a spray dried microparticle betulinic acid/HP-β-CD formulation (BAC) aiming to assess the BAF and BAC efficacy as a photosensitizer in PDT for application in ovarian cancer. BAF and BAC were submitted to assays in the presence of LED (λ = 420 nm) under different conditions (2.75 J/cm2, 5.5 J/cm2, and 11 J/cm2) and in absence of irradiation, after 5 min or 4 h of contact with ovarian carcinoma cells (A2780) or fibroblast murine cells (3T3). Furthermore, HPLC-MS/MS and MALDI-MSI methods were developed and validated in plasma and tumor of mice proving suitable for in vivo studies. The results found a greater photoinduced cytotoxic effect for the BAC at low concentration for A2780 when irradiated with LED with similar results for fluorescence microscopy. The results motivate us to continue the studies with the BA as a potential antitumor bioactive compound The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Safety of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Safety of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cui, Tianming; Li, Shukai; Chen, Shengfu; Liang, Ying; Sun, Haotian; Wang, Longgang published an article in 2021. The article was titled 《””Stealth”” dendrimers with encapsulation of indocyanine green for photothermal and photodynamic therapy of cancer》, and you may find the article in International Journal of Pharmaceutics (Amsterdam, Netherlands).Electric Literature of C20H14O The information in the text is summarized as follows:

Poly(amido amine) dendrimers and indocyanine green have inevitable interaction with proteins and cells, which induces biol. toxicity and reduces therapeutic efficacy in vivo. To overcome these shortcomings, a new drug delivery system G5MEK7C(n)-ICG with a “”stealth”” layer was prepared The surface of G5MEK7C(n)-ICG was modified with double-layer super hydrophilic zwitterionic materials. In the “”stealth”” double-layer structure, the outer layer was consisted of zwitterionic Glu-Lys-Glu-Lys-Glu-Lys-Cys (EK7) peptide, and the inner layer was composed of amino and carboxyl groups with a ratio of 1:1. DLS results showed that the average hydrodynamic size of G5MEK7C(n)-ICG was about 25-30 nm, and the zeta potential was proven to undergo a slight charge reversal with the increasing pH values of solutions Furthermore, G5MEK7C(n)-ICG exhibited excellent biocompatibility to red blood cells and proteins resistance. Photothermal and photodynamic experiments demonstrated that G5MEK7C(n)-ICG had a good photothermal conversion effect and generated singlet oxygen (1O2) under laser irradiation The MTT and hemolysis results showed that the toxicity of G5 PAMAM was significantly reduced after modification double-layer structure. Cytotoxicity studies and flow cytometry showed G5MEK7C(70)-ICG under laser irradiation had a good effect on killing A549 cells. More importantly, the tumor inhibition rate of mice treated with G5MEK7C(70)-ICG (under laser irradiation) was 78.2% in vivo, which was higher than that of mice treated with free ICG. Compared with free ICG, G5MEK7C(70)-ICG caused less damage to the liver according to the enzyme activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Therefore, dendrimers modified with a zwitterionic double layer will be a promising candidate as a drug delivery system. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Electric Literature of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Electric Literature of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application of 5471-63-6In 2021 ,《PSMA-targeted melanin-like nanoparticles as a multifunctional nanoplatform for prostate cancer theranostics》 appeared in Journal of Materials Chemistry B: Materials for Biology and Medicine. The author of the article were Dai, Liqun; Shen, Guohua; Wang, Yuanyuan; Yang, Peng; Wang, Hong; Liu, Zhenhua. The article conveys some information:

Prostate-specific membrane antigen (PSMA) is highly expressed on the surface of most prostate tumor cells and is considered a promising target for prostate cancer imaging and treatment. It is possible to establish a PSMA-targeted theranostic probe to achieve early diagnosis and treatment of this cancer type. In this contribution, we prepared a multifunctional melanin-like polydopamine (PDA) nanocarrier decorated with a small-mol. PSMA inhibitor, N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-(S)-l-lysine (DCL). PDA-DCL was then functionalized with perfluoropentane (PFP) and loaded with the photosensitizer chlorin e6 (Ce6) to give Ce6@PDA-DCL-PFP, which was successfully used for ultrasound-guided combined photodynamic/photothermal therapy (PDT/PTT) of prostate cancer. Compared with the corresponding non-targeted probe (Ce6@PDA-PEG-PFP), our targeted probe induced higher cellular uptake in vitro (6.5-fold) and more tumor accumulation in vivo (4.6-fold), suggesting strong active targeting capacity. Meanwhile, this new nanoplatform significantly enhanced the ultrasound contrast signal at the tumor site in vivo, thus facilitating precise and real-time detection of the tumor. In addition, this Ce6-loaded PDA nanoplatform produced a synergistic effect of PDT and PTT under 660 nm and 808 nm irradiation, inducing a more efficient killing effect compared with the individual therapy in vitro and in vivo. Furthermore, the tumor in the targeted group was more effectively suppressed than that in the non-targeted group under the same irradiation condition. This multifunctional probe may hold great potential for precise and early theranostics of prostate cancer.1,3-Diphenylisobenzofuran(cas: 5471-63-6Application of 5471-63-6) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Application of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zhou, Junli; Li, Yite; Wang, Lei; Xie, Zhigang published an article in 2021. The article was titled 《Structural diversity of nanoscale zirconium porphyrin MOFs and their photoactivities and biological performances》, and you may find the article in Journal of Materials Chemistry B: Materials for Biology and Medicine.Product Details of 5471-63-6 The information in the text is summarized as follows:

Photoactive MOF-based delivery systems are highly attractive for photodynamic therapy (PDT), but the fundamental interplay among structural parameters and photoactivity and biol. properties of these MOFs remains unclear. Herein, porphyrinic MOF isomers (TCPP-MOFs), constructing using the same building blocks into distinct topologies, have been selected as ideal models to understand this problem. Both the intramol. distances and mol. polarization within TCPP-MOFs isomers collectively contribute to the photoactivity of generating reactive oxygen species. Remarkably, the morphol.-determined endocytic pathways and cytotoxicity, as well as good biocompatibility have been confirmed for TCPP-MOF isomers without any chem. modification for the first time. Besides the topol.-dependent photoactive regulation, this work also provides in-depth insights into the biol. effect from the MOF nanoparticles with controllable structural factors, benefiting further in vivo applications and clin. transformation. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6Product Details of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Product Details of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem