Luo, Xiangjie; Chi, Xiaoqin; Lin, Yaying; Yang, Zhaoxuan; Lin, Hongyu; Gao, Jinhao published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《A camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations》.Computed Properties of C20H14O The article contains the following contents:
Mitochondria are crucial regulators of the intrinsic pathway of apoptosis. Herein, we report a photosensitizer-conjugated camptothecin (CPT)-based prodrug for combinative chemo-photodynamic treatment of solid tumors with cascade activations. Upon light irradiation, our prodrug can effectively target the mitochondria of cancer cells, generate singlet oxygen to increase the level of reactive oxygen species (ROS) and trigger ROS-responsive release of CPT, which synergistically induce mitochondrial damage and cause the apoptosis of cancer cells, therefore achieving high therapeutic efficacy for solid tumors and minimized adverse effects to normal tissues. Our prodrug holds great promise as a potent and inspiring means for cancer treatment. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O)
1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Computed Properties of C20H14O
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem