Xing, Enyun’s team published research in Advanced Healthcare Materials in 2021 | CAS: 5471-63-6

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Application In Synthesis of 1,3-Diphenylisobenzofuran

Xing, Enyun; Du, Yingying; Yin, Juanjuan; Chen, Minghui; Zhu, Mengyao; Wen, Xiaona; Xu, Jialiang; Feng, Yaqing; Meng, Shuxian published their research in Advanced Healthcare Materials in 2021. The article was titled 《Multi-functional Nanodrug Based on a Three-dimensional Framework for Targeted Photo-chemo Synergetic Cancer Therapy》.Application In Synthesis of 1,3-Diphenylisobenzofuran The article contains the following contents:

Targeted synergistic therapy has broad prospects in tumor treatments. Here, a multi-functional nanodrug GDYO-CDDP/DOX@DSPE-PEG-MTX (GCDM) based on three traditional anticancer drugs (doxorubicin (DOX), cisplatin (CDDP) and methotrexate (MTX)) modified graphdiyne oxide (GDYO) is described, for diagnosis and targeted cancer photo-chemo synergetic therapy. In this system, for the first time, these three traditional anti-cancer drugs have played new roles and can reduce multidrug resistance through synergistic anti-tumor effects. Cisplatin can be hybridized with GDYO to form a multifunctional and well-dispersed three-dimensional framework, which can not only be used as nano-drug carriers to achieve high drug loading rates (40.3%), but also exhibit excellent photothermal conversion efficiency (47%) and good photodynamic effects under NIR irradiation Doxorubicin (DOX) is loaded onto GDYO-CDDP through π-π stacking, which is used as an anticancer drug and as a fluorescent probe for nanodrug detection. Methotrexate (MTX) can be applied in tumor targeting and play a role in synergistic chemotherapy with DOX and CDDP. The synthesized multi-functional nanodrug GCDM has good biocompatibility, active targeting, long-term retention, sustained drug release, excellent fluorescence imaging capabilities, and remarkable photo-chemo synergistic therapeutic effects. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Application In Synthesis of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

de Souza, Thalita F. M.’s team published research in Dyes and Pigments in 2020 | CAS: 5471-63-6

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Electric Literature of C20H14O

《Unsymmetrical zinc(II) phthalocyanine and zinc(II) naphthalocyanine with 2,3-Dicyano-1,4-diphenylnaphthalene precursor》 was written by de Souza, Thalita F. M.; Torres Antonio, Felipe Cesar; Homem-de-Mello, Paula; Ribeiro, Anderson O.. Electric Literature of C20H14OThis research focused onunsym zinc phthalocyanine naphthalocyanine preparation photophys photochem; dicyanodiphenylnaphthalene precursor preparation; Diels Alder diphenylisobenzofuran fumaronitrile. The article conveys some information:

The synthesis, photophys. and photochem. properties of an unsym. zinc(II) phthalocyanine and zinc(II) naphthalocyanine derivative are described. The precursor 2,3-Dicyano-1,4-diphenylnaphthalene was synthesized by Diels-Alder reaction with 1,3-diphenylisobenzofuran and fumaronitrile. The macrocycles were characterized by MALDI-TOF, FTIR, 1H NMR and UV-vis. On their spectroscopy, the impact of the added aromatic moiety was investigated in solution, observing a bathochromic shift in UV-vis absorption, emission and excitation spectra. The structural and electronic properties indicated that the geometry reorganization during the excitation and relaxation processes, and the dipole moment of the ground state, increases the generation of singlet oxygen in solution The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Electric Literature of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Electric Literature of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Shih, Yi-Fan’s team published research in Journal of Fluorine Chemistry in 2021 | CAS: 5471-63-6

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Recommanded Product: 1,3-Diphenylisobenzofuran

Shih, Yi-Fan; Lee, Hsin-Yi; Huang, Ying-Hsuan; Chuang, Fu-Yu; Lee, Gon-Ann published their research in Journal of Fluorine Chemistry in 2021. The article was titled 《Study of properties of 3-fluorinated cyclopropene derivatives》.Recommanded Product: 1,3-Diphenylisobenzofuran The article contains the following contents:

Treatment of 1-bromo-2,2-dichloro-3-trimethylsilylcyclopropane with 5 equiv of CsF resulted in the formation of a chlorocyclopropenyl cation, which, under different conditions, further reacted with fluoride ion selectively to generate 3,3-difluorocyclopropene or 1-chloro-3-fluorocyclopropene. The Diels-Alder reactions of fluorinated cyclopropene derivatives with DPIBF yielded only exo or exo-anti adducts. On treatment of fused tricyclic cis-1-chloro-3-fluorocyclopropane derivative with n-BuLi, 3-fluorocyclopropene derivative was formed, which underwent Diels-Alder reaction with DPIBF to give an endo-endo adduct. Addnl., fused tricyclic 3,3-difluorocyclopropane and cis-1-chloro-3-fluorocyclopropane derivatives underwent ring-opening reaction of cyclopropane by BF3·Et2O, resp., and 1,4-diphenylnaphthalene derivatives were obtained. The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Recommanded Product: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zeng, Weiwei’s team published research in Advanced Healthcare Materials in 2020 | CAS: 5471-63-6

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Recommanded Product: 5471-63-6

《An Ultrasound-Excitable Aggregation-Induced Emission Dye for Enhanced Sonodynamic Therapy of Tumors》 was written by Zeng, Weiwei; Xu, Yan; Yang, Weitao; Liu, Kai; Bian, Kexin; Zhang, Bingbo. Recommanded Product: 5471-63-6This research focused ontumor sonodynamic therapy ultrasound aggregation induced emission dye; aggregation‐induced emission; reactive oxygen species; sonodynamic therapy; sonosensitizers. The article conveys some information:

Ultrasound (US)-triggered sonodynamic therapy (SDT) can significantly solve the problem of tissue penetrability of light of photodynamic therapy (PDT) that has long vexed physicians in clinics. However, there is a great shortage of sonosensitizers for SDT. Currently, several photosensitizers and their derivatives have been reported for SDT but these dyes are usually quenched when aggregated due to aggregation-caused quenching (ACQ) effect. In this work, aggregation-induced emission (AIE) dye (TTMN) assembled nanoparticles (S-AIE) are synthesized and employed as sonosensitizers for enhanced SDT due to the unique properties of the AIE dye and the deep tissue penetration of ultrasound. Results show that S-AIE can generate potent singlet oxygen (1O2) under US irradiation to induce cancer cells apoptosis and clearly inhibit tumor growth in vitro and in vivo. In particular, the intrinsic fluorescence of AIE dye can guide the procedure of SDT. To the best of current knowledge, this is the first demonstration of AIE dyes being used as sonosensitizers for SDT and importantly, this work could inspire other more efficient AIE dyes for being used as sonosensitizers for SDT of deep-seated tumors. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Recommanded Product: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Kayser, Margaret M.’s team published research in Spectroscopy Letters in 1988 | CAS: 105694-46-0

7-Iodoisobenzofuran-1(3H)-one(cas: 105694-46-0) belongs to benzofurans.Quality Control of 7-Iodoisobenzofuran-1(3H)-oneBenzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Quality Control of 7-Iodoisobenzofuran-1(3H)-oneOn September 30, 1988 ,《The internal steric push-effect: its consequences on the reactivity of carbonyl functions in 3-substituted phthalic anhydrides》 was published in Spectroscopy Letters. The article was written by Kayser, Margaret M.. The article contains the following contents:

The 13C NMR for a number of 3-substituted phthalic anhydrides and corresponding lactones were measured. Substituent effects were discussed. MM2 calculations for several 3-substituted phthalic anhydrides predict that the substituent and the neighboring carbonyl group remain coplanar and within the plane of the aromatic ring. To alleviate the imposed crowding, there is an in-plane distortion of the bond angle of the substituent and the carbonyl function. The observed angle of distortion increases with increasing steric demand of the substituent, in agreement with repulsive van der Waals interaction between those two groups. Diminished reactivity of the ortho carbonyl groups vis-a-vis nucleophiles in 3-substituted phthalic anhydrides may be linked to the internal steric push-effect which causes the displacement of electrons in the CO bond from O to C. The experimental process involved the reaction of 7-Iodoisobenzofuran-1(3H)-one(cas: 105694-46-0Quality Control of 7-Iodoisobenzofuran-1(3H)-one)

7-Iodoisobenzofuran-1(3H)-one(cas: 105694-46-0) belongs to benzofurans.Quality Control of 7-Iodoisobenzofuran-1(3H)-oneBenzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Sreedhanya, S.’s team published research in Materials Today: Proceedings in 2020 | CAS: 5471-63-6

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Synthetic Route of C20H14O

《Spectroscopic and theoretical methods to probe protein-ligand binding》 was published in Materials Today: Proceedings in 2020. These research results belong to Sreedhanya, S.; Jeena, V. R.; Ammu, S.; Aravindakumar, C. T.; Aravind, Usha K.. Synthetic Route of C20H14O The article mentions the following:

Protein-ligand binding studies have gained considerable attention owing to its application in biomedical research. The present study discusses the application of spectroscopic and theor. methods to probe the interaction between a model ligand, 1, 3-diphenylisobenzofuran (DPBF) and bovine serum albumin (BSA). The quenching of the intrinsic fluorescence of BSA arising from tryptophan residue in the presence of DPBF is monitored to follow the nature and mechanism associated with the binding process. The binding affinity and number of binding sites have been investigated. Synchronous fluorescence and UV-Vis spectroscopic studies have been carried out to follow the changes in the fluorophore micro-environment and binding mechanism. Theor. methods such as fluorescence resonance energy transfer (FRET) and mol. docking are also employed to predict the binding mechanism, binding modes, binding sites and the distance between the tryptophan residue in BSA and DPBF. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Synthetic Route of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Synthetic Route of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fuchibe, Kohei’s team published research in Chemistry – An Asian Journal in 2020 | CAS: 5471-63-6

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Synthetic Route of C20H14O

《Fluorinated Phenanthrenes as Aryne Precursors: PAH Synthesis Based on Domino Ring Assembly Using 1,1-Difluoroallenes》 was written by Fuchibe, Kohei; Abe, Masashi; Idate, Hiroto; Ichikawa, Junji. Synthetic Route of C20H14O And the article was included in Chemistry – An Asian Journal in 2020. The article conveys some information:

On treatment with the catalyst InBr3, 1,1-difluoroallenes e.g., [1-(3,3-difluoropropa-1,2-dien-1-yl)cyclopent-3-en-1-yl]benzene that bear a cyclopentene moiety and an aryl group underwent domino ring assembly in the presence or absence of N-bromosuccinimide or N-iodosuccinimide to afford aryne precursors such as three-ringed ortho-fluoro(halo)phenanthrenes, four-ringed ortho-fluoro(halo)tetraphenes, ortho-fluoro(halo)chrysenes and 6-fluoro-benzo[c]phenanthrene. Metalation of the aryne precursors followed by elimination of the fluoride resulted in the unprecedented systematic generation of arynes bearing π-extended systems e.g., 9,14-dihydro-9,14-diphenyl-9,14-epoxybenzo[b]triphenylene. Diels-Alder reactions of these arynes with isobenzofurans afforded the corresponding cycloadducts e.g., I, whose reductive aromatization in an SnCl2/HBr system furnished fully aromatized benzotriphenylenes e.g., 9,14-diphenylbenzo[b]triphenylene. In addition, oxidative aryl-aryl coupling (Scholl reaction) of these benzotriphenylenes facilitated the synthesis of ‘half HBCs’ (hexabenzocoronenes) II (R1 = H, n-Hex, t-Bu). In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Synthetic Route of C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Synthetic Route of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Luo, Huanhuan’s team published research in Advanced Functional Materials in 2021 | CAS: 5471-63-6

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Safety of 1,3-Diphenylisobenzofuran

Luo, Huanhuan; Kong, Li; Zhang, Feng; Huang, Chenglong; Chen, Jiayi; Zhang, Hongbo; Yu, Han; Zheng, Song; Xu, Hongwei; Zhang, Yiran; Deng, Lianfu; Chen, Gang; Santos, Helder A.; Cui, Wenguo published an article in 2021. The article was titled 《Light-Controlled Nanosystem with Size-Flexibility Improves Targeted Retention for Tumor Suppression》, and you may find the article in Advanced Functional Materials.Safety of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Although great promise has been achieved with nanomedicines in cancer therapy, limitations are still encountered, such as short retention time in the tumor. Herein, a nanosystem that can modulate the particle size in situ by near-IR (NIR) light is self-assembled by crosslinking the surface-modified poly(lactic-co-glycolic acid) from the up-conversion nanoparticle with indocyanine green and doxorubicin-nitrobenezene-polyethylene glycol (DOX-NB-PEG). The nanosystem with its small size (100 nm) achieves better tumor targeting, while the PEG on the surface of the nanosystem can effectively shield the adsorption of proteins during blood circulation, maintaining a stable nanostructure and achieving good tumor targeting. Moreover, the nanosystem at the tumor realizes the rapid shedding of PEG on its surface by NIR irradiation, and the enhanced cellular uptake. At the same time, aggregation occurs inside the nanosystem to form bigger particles (600 nm) in situ, prolonging the retention time at the tumor and producing enhanced targeted therapeutic effects. In vitro data show higher cellular uptake and a higher rate of apoptosis after irradiation, and the in vivo data prove that the nanosystem have a longer residence time at the tumor site after NIR irradiation This nanosystem demonstrates an effective therapeutic strategy in targeted synergistic tumors. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Safety of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Safety of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Kim, Jinwoo’s team published research in Journal of Medicinal Chemistry in 2017 | CAS: 50551-57-0

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.HPLC of Formula: 50551-57-0Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Kim, Jinwoo; Jung, Yu Kyoung; Kim, Chonsaeng; Shin, Jin Soo; Scheers, Els; Lee, Joo-Youn; Han, Soo Bong; Lee, Chong-Kyo; Neyts, Johan; Ha, Jae-Du; Jung, Young-Sik published an article in Journal of Medicinal Chemistry. The title of the article was 《A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication》.HPLC of Formula: 50551-57-0 The author mentioned the following in the article:

Human rhinoviruses (hRVs) are the main causative pathogen for common colds and are associated with the exacerbation of asthma. The wide variety in hRV serotypes has complicated the development of rhinovirus replication inhibitors. In the current investigation, the authors developed a novel series of benzothiophene derivatives and their analogs that potently inhibit the replication of both hRV-A and hRV-B strains. Compound 6g (I) inhibited the replication of hRV-B14, A21, and A71, with resp. EC50 values of 0.083, 0.078, and 0.015 μM. The results of a time-of-addition study against hRV-B14 and hRV-A16 and resistant mutation anal. on hRV-B14 implied that 6g acts at the early stage of the viral replication process, interacting with viral capsid protein. A mol. docking study suggested that 6g has a capsid-binding mode similar to that of pleconaril. Finally, derivatives of 6 also displayed significant inhibition against poliovirus 3 (PV3) replication, implying their potential inhibitory activities against other enterovirus species. After reading the article, we found that the author used Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0HPLC of Formula: 50551-57-0)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.HPLC of Formula: 50551-57-0Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chen, Wei’s team published research in Organic & Biomolecular Chemistry in 2017 | CAS: 50551-57-0

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Related Products of 50551-57-0Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

The author of 《Efficient synthesis of chiral benzofuryl β-nitro alcohols via a catalytic asymmetric Henry reaction》 were Chen, Wei; Zhou, Zhao-Hui; Chen, Hong-Bin. And the article was published in Organic & Biomolecular Chemistry in 2017. Related Products of 50551-57-0 The author mentioned the following in the article:

Chiral β-amino alc. ligands were found to be effective for the copper(II)-catalyzed asym. Henry reaction of benzofuran-2-carboxaldehydes with nitromethane, which led to the formation of (S)-enriched benzofuryl β-nitro alcs. with satisfactory enantioselectivities (up to 98% ee). The experimental process involved the reaction of Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0Related Products of 50551-57-0)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Related Products of 50551-57-0Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem