Day: October 19, 2022

《Tuning Optical Properties of BODIPY Dyes by Pyrrole Conjugation for Photoacoustic Imaging》 was written by Merkes, Jean Michel; Lammers, Twan; Kancherla, Rajesh; Rueping, Magnus; Kiessling, Fabian; Banala, Srinivas. Formula: C20H14O And the article was included in Advanced Optical Materials in 2020. The article conveys some information:

Photoacoustic imaging (PAI) is increasingly employed in (pre-) clin. research, thus, development of suitable contrast agents, in particular fluorescence-quenched chromophores, for PAI is of high importance. Small mol. dyes are appropriate due to favorable circulation, excretion properties, and ease of conjugation to targeting moieties. The BODIPY chromophores have been widely used in bioimaging, yet they are not ideal for PAI due to high fluorescence. Hence, here nonfluorescent BODIPY are designed by 1H-pyrrole conjugation (PyBODIPY) to apply as probes for PAI. The PyBODIPYs exhibit absorption maxima up to 800 nm, and PA signal could be detected in concentrations of 1 nmol mL-1 and 35 pmol mm-3, by tube and tissue phantom, resp. In addition to nonfluorescent, PyBODIPYs are non-phototoxic, photostable, and show high molar extinction coefficients, as well as inertness toward nucleophilic addition PyBODIPYs are modified with PEG-400, to improve aqueous solubility and to enable in vivo imaging. Thus, PyBODIPY is an attractive small mol. to use as PA contrast agent, which could be coupled to targeting ligands for in vivo use. In addition, 1H-pyrrole conjugation might be applied to the design of novel near-IR ranged quenchers suitable for PAI, and promote the development of probes for clin. translation. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Lena, Gersande; Trapani, Joseph A.; Sutton, Vivien R.; Ciccone, Annette; Browne, Kylie A.; Smyth, Mark J.; Denny, William A.; Spicer, Julie A. published their research in Journal of Medicinal Chemistry on December 11 ,2008. The article was titled 《Dihydrofuro[3,4-c]pyridinones as Inhibitors of the Cytolytic Effects of the Pore-Forming Glycoprotein Perforin》.SDS of cas: 53860-74-5 The article contains the following contents:

Dihydrofuro[3,4-c]pyridinones are the first class of small mols. reported to inhibit the cytolytic effects of the lymphocyte toxin perforin. A lead structure was identified from a high throughput screen, and a series of analogs I (X = O, S; Y = O, NH; R = Ph, 4-FC6H4, 2-furyl, 5-methyl-2-thienyl, 3-thienyl, 2-benzofuryl, 3-benzothienyl, 3-indolyl, etc.) were designed and prepared to explore structure-activity relationships around the core bicyclic ring and pendant aryl(heteroaryl) ring. This resulted in the identification of a submicromolar inhibitor of the perforin-induced lysis of Jurkat T-lymphoma cells. After reading the article, we found that the author used 6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5SDS of cas: 53860-74-5)

6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5) belongs to benzofurans.SDS of cas: 53860-74-5Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem