Day: October 12, 2022

Gao, Min; Luo, Yanshu; Xu, Qianlan; Zhao, Yukun; Gong, Xiangnan; Xia, Yuanzhi; Hu, Lin published the artcile< A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole-Fused Oxacycles>, Product Details of C10H10O4, the main research area is oxindole peroxide chiral phase transfer catalyst enantioselective annulation DFT; chiral spirooxindole oxacycle stereoselective preparation; annulation reaction; organocatalysis; oxygen heterocycles; peroxides; umpolung reaction.

A unified catalytic asym. (N+1) (N=4, 5) annulation reaction of oxindoles with bifunctional peroxides has been achieved in the presence of a chiral phase-transfer catalyst (PTC). This general strategy utilizes peroxides as unique bielectrophilic four- or five-atom synthons to participate in the C-C and the subsequent umpolung C-O bond-forming reactions with one-carbon unit nucleophiles, thus providing a distinct method to access the valuable chiral spirooxindole-tetrahydrofurans and -tetrahydropyrans with good yields and high enantioselectivities under mild conditions. DFT calculations were performed to rationalize the origin of high enantioselectivity. The gram-scale syntheses and synthetic utility of the resultant products were also demonstrated.

Angewandte Chemie, International Edition published new progress about C-C bond formation. 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Product Details of C10H10O4.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Colmenares-Cruz, Stephania; Gonzalez-Cortazar, Manases; Castaneda-Ramirez, Gloria Sarahi; Andrade-Gallegos, Rene H.; Sanchez, Jose E.; Aguilar-Marcelino, Liliana published the artcile< Nematocidal activity of hydroalcoholic extracts of spent substrate of Pleurotus djamor on L3 larvae of Haemonchus contortus>, Related Products of 531-88-4, the main research area is Haemonchus contortus Pleurotus djamor hydroalcoholic extract nematocidal activity; Biodirected fractionation; Haemonchus contortus; Harvest time; Nematocidal compounds; Nematocidal extracts.

The objective of this study was to evaluate and compare the in vitro lethal effect of the hydroalcoholic extract of the spent substrate of Pleurotus djamor ECS-123, obtained at 15 days of colonization (SPS) and at the first (SPS1) and second (SPS2) harvests, against infective larvae L3 of Haemonchus contortus. The in vitro lethal effect was evaluated by the L3 larval mortality test (LM) using six concentrations: 1.25, 2.5, 5, 10, 20, and 40 mg/mL, with ivermectin and thiabendazole (5 mg/mL) as controls. The first harvest extract (SPS1) of strain ECS-123 was subjected to liquid-liquid bipartition, which resulted in two fractions: aqueous (PdAcO) and Et acetate (PdAct). The chem. fractionation of PdAct with the highest mortality rate (80.11%) was carried out with open-column chromatog., giving a total of 13 fractions, which were analyzed by thin-layer chromatog. (TLC) and grouped into 5 mixtures (R1;1-3, R2;4-7, R3;8-9, R4;10-11 and R5;12-13). Subsequently, the mixtures were evaluated against H. contortus L3 larvae. Finally, the components of the mixtures with the highest nematocidal effects were evaluated by gas chromatog. coupled to mass spectrometry (GC-MS). The data were analyzed with a completely randomized design through ANOVA using the generalized linear model (GLM) with the quotRquot program. The purification and characterization of R4 and R5 by GC-MS revealed the presence of the following compounds: veratryl alc., 4-hydroxy-3,5,5 trimethyl-4-[3-oxo-1-butenyl]-2- cyclohexen-1-one, caffeine and 5,6-dimethoxy-1(3 H) isobenzofuranone. This information allowed for the identification of nematocidal compounds in the degraded substrate of P. djamor, an activity that had not been reported previously.

Veterinary Parasitology published new progress about Aqueous solutions. 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Related Products of 531-88-4.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Liu, Bin; Zhou, Xigeng published the artcile< Synthesis of 1,2-phenylenedimethanols by base-promoted reduction of isobenzofuran-1(3H)-ones with silane>, Category: benzofurans, the main research area is phenylenedimethanol preparation isobenzofuranone reduction base silane.

An efficient method for preparation of substituted 1,2-phenylenedimethanols and aliphatic 1,4-diols that are valuable intermediates in organic synthesis, was developed by the base-promoted reduction of isobenzofuran-1(3H)-ones and γ-lactones with silane under mild conditions. Compared with traditional procedures using stoichiometric amounts of metal hydrides and alkyl reductants, the present method avoids the use of sensitive reagents and is operationally simple and a broad variety of functional groups are tolerated.

Chinese Chemical Letters published new progress about Bases Role: RGT (Reagent), RACT (Reactant or Reagent). 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zhou, Chao; Zhao, Junqi; Chen, Wenkun; Imerhasan, Mukhtar; Wang, Jun published the artcile< Synthesis of 3-unsubstituted phthalides from aryl amides and paraformaldehyde via Ruthenium(II)-catalyzed C-H activation>, Related Products of 531-88-4, the main research area is phthalide preparation aryl amide paraformaldehyde Ruthenium catalyst hydroxymethylation lactonization.

A straightforward and convenient route has been developed for the synthesis of 3-unsubstituted phthalide derivatives from aryl amides and paraformaldehyde by ruthenium(II)-catalyzed C-H activation. The reaction proceeds through tandem ortho-hydroxymethylation of aryl amide and subsequent intramol. lactonization.

European Journal of Organic Chemistry published new progress about Aromatic amides Role: RCT (Reactant), RACT (Reactant or Reagent). 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Related Products of 531-88-4.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chen, Wang; Feng, Zili; Hu, Daihua; Meng, Jin published the artcile< Design and Synthesis of Arylnaphthalene Lignan Lactone Derivatives as Potent Topoisomerase Inhibitors>, Reference of 531-88-4, the main research area is arylnaphthalene lignan lactone derivative topoisomerase inhibitor design antitumor activity; Arylnaphthalene lignin lactones; anti-proliferation activity; catalytic inhibitor; cell proliferation assay; chemotherapeutic agents; topoisomerase IIα..

Arylnaphthalene lignan lactones are a class of natural products containing the phenyl-naphthyl skeleton. Some arylnaphthalene lignan lactones have been used in clin. practice as antitumor agents, due to their cytotoxicity and inhibitory activities against DNA topoisomerase I (Topo I) and topoisomerase II (Topo II). This study presents the design and synthesis of arylnaphthalene lignan lactones derivatives The inhibitory activities against Topo I and Topo IIα and antitumor activities of these compounds were assayed. A series of arylnaphthalene lignan lactones derivatives have been designed and synthesized, using the Diels-Alder reaction and Suzuki reaction as the key steps. Their antiproliferation activities were evaluated by sulforhodamine B assay on human breast cancer MDAMB-231, MDA-MB-435 and human cervical cancer HeLa cells. DNA relaxation assays were employed to examine the inhibitory activity of compounds 1-22 on Topo I and Topo IIα in vitro. Flow cytometry anal. was performed to study the drug effects on cell cycle progressions. Seven compounds exhibited the modest anti-proliferation activity with IC50 values between 1.36 and 20 μM. Compounds 3, 19 and 22 showed potent inhibitory activities with IC50 values less than 1 μM. DNA relaxation assay revealed that compound 22 showed potent inhibitory activity against Topo IIα in vitro. Compound 22 also induced DNA breaks in MDA-MB-435 cells evidenced by comet tails and the accumulation of γ-H2AX foci. The ability of 22 in inducing DNA breaks mediated by Topo IIα resulted in G2/M phase arrest and apoptosis. This work indicates that arylnaphthalene lignan lactones derivatives represent a novel type of Topo IIα inhibitory scaffold for developing new antitumor chemotherapeutic agents.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about Antiproliferative agents. 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Reference of 531-88-4.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Du, Tian; Gao, Ruiheng; Deng, Yunfeng; Wang, Cheng; Zhou, Qian; Geng, Yanhou published the artcile< Indandione-Terminated Quinoids:Facile Synthesis by Alkoxide-Mediated Rearrangement Reaction and Semiconducting Properties>, Recommanded Product: 5,6-Dimethoxyisobenzofuran-1(3H)-one, the main research area is indandione terminated quinoid preparation alkoxide rearrangement semiconductor; aromatic dialdehydes; electron transport; indandione; organic thin-film transistor; quinoidal compounds.

A series of 1,3-indandione-terminated π-conjugated quinoids were synthesized by alkoxide-mediated rearrangement reaction of the resp. alkene precursors, followed by air oxidation This new protocol allows access to quinoidal compounds with variable termini and cores. The resulting quinoids all show LUMO levels <-4.0 eV and molar absorptivities >105 L mol-1 cm-1. The optoelectronic properties of these compounds can be regulated by tuning the central cores as well as the aryl termini ascribed to the delocalized frontier MOs over the entire mol. skeleton involving aryl termini. n-Channel organic thin-film transistors with electron mobility of up to 0.38 cm2 V-1 s-1 were fabricated, showing the potential of this new class of quinoids as organic semiconductors.

Angewandte Chemie, International Edition published new progress about Crystal structure. 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Recommanded Product: 5,6-Dimethoxyisobenzofuran-1(3H)-one.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem