Kim, Jinwoo; Jung, Yu Kyoung; Kim, Chonsaeng; Shin, Jin Soo; Scheers, Els; Lee, Joo-Youn; Han, Soo Bong; Lee, Chong-Kyo; Neyts, Johan; Ha, Jae-Du; Jung, Young-Sik published an article in Journal of Medicinal Chemistry. The title of the article was 《A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication》.HPLC of Formula: 50551-57-0 The author mentioned the following in the article:
Human rhinoviruses (hRVs) are the main causative pathogen for common colds and are associated with the exacerbation of asthma. The wide variety in hRV serotypes has complicated the development of rhinovirus replication inhibitors. In the current investigation, the authors developed a novel series of benzothiophene derivatives and their analogs that potently inhibit the replication of both hRV-A and hRV-B strains. Compound 6g (I) inhibited the replication of hRV-B14, A21, and A71, with resp. EC50 values of 0.083, 0.078, and 0.015 μM. The results of a time-of-addition study against hRV-B14 and hRV-A16 and resistant mutation anal. on hRV-B14 implied that 6g acts at the early stage of the viral replication process, interacting with viral capsid protein. A mol. docking study suggested that 6g has a capsid-binding mode similar to that of pleconaril. Finally, derivatives of 6 also displayed significant inhibition against poliovirus 3 (PV3) replication, implying their potential inhibitory activities against other enterovirus species. After reading the article, we found that the author used Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0HPLC of Formula: 50551-57-0)
Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.HPLC of Formula: 50551-57-0Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem