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1-Methyl-3-ethyl imidazolium bromide [meim]Br/basic alumina (Al2O3) has been found to promote the cyclocondensation of chloroacetone/chloroethyl acetate with salicylaldehydes under conventional as well as microwave irradiation to yield benzofuran derivatives.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3801O – PubChem

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The BMP pathway is a promising new target for the design of therapeutic agents for the treatment of low bone mass. To enrich our understanding of SAR and based on our previously concluded structure-effect relationship, 23 derivatives were prepared in this work. The synthesis, up-regulating activities on BMP-2 expression, and bone loss prevention efficacies of these compounds in rats with glucocorticoid-induced osteoporosis are presented. The bone histology of the tested rats assessed through light microscopy showed that compounds 1, 21, 35, and 38 significantly increased the trabecula compared with the model group, and the trabecula of the groups treated with 8a was similar to that obtained with raloxifene and alfacalcidol. The compounds exhibited potential for development as anabolic agents.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3802O – PubChem

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The present invention provides an aminostyrylbenzofuran compound of Formula (I), and a pharmaceutical composition comprising same. The pharmaceutical composition of the present invention comprising the compound of Formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof as an active ingredient can be useful for the prevention and treatment of degenerative brain diseases caused by accumulation of beta-amyloid.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3790O – PubChem

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Formula: C12H12O4, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 50551-57-0, name is Ethyl 6-methoxybenzofuran-2-carboxylate. In an article,Which mentioned a new discovery about 50551-57-0

The first total chemical synthesis of a cis-syn furan-side photoproduct between a psoralen derivative and thymidine is described. The key step in the synthesis was an intramolecular [2 + 2] photocycloaddition, which directed the stereochemical course of the reaction to afford a product equivalent to that formed when a psoralen molecule is allowed to react at a 5′-TpA-3′ site in DNA. A model system consisting of a simple benzofuranyl acid tethered to the 5′ hydroxyl of thymidine showed that it was possible to bias the stereochemical outcome of the photochemical reaction in favor of the desired cis-syn product. Further refinement of the model system allowed for the elaboration of a benzofuran-thymidine photoproduct into a cis-syn 2-carbomethoxypsoralen furan-side thymidine monoadduct. The stereochemistry of all photoproducts as established by NMR and CD spectroscopy indicated that the cycloadditions occurred on the 3′ face of thymine, the equivalent of a psoralen monoadduct in a 5′-TpA-3′ site in DNA. Previously, the inability to program the sequence context of psoralen-DNA adducts has constrained certain biological studies, such as experiments aimed at deciphering the transcriptional effects of adducts at TATA sites. This method is a key step toward overcoming that problem.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3798O – PubChem

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S1P RECEPTORS MODULATORS AND THEIR USE THEREOF

The invention relates to novel compounds that have S1P receptor modulating activity. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, autoimmune response. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as autoimmune response.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3787O – PubChem

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Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2- phenylethyl)arylamides

A series of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides were prepared, using an efficient three- to five-step synthesis, and evaluated for their inhibitory activity against human cytochrome P450C24A1 (CYP24A1) hydroxylase. Inhibition ranged from IC50 0.3-72 muM compared with the standard ketoconazole IC50 0.52 muM, with the styryl derivative (11c) displaying enhanced activity (IC50 = 0.3 muM) compared with the standard, providing a useful preliminary lead for drug development.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3792O – PubChem

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Novel imidazoline compounds as partial or full agonists of D 2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI

Based on the well known biological versatility of the imidazoline nucleus, we prepared the novel derivatives 3a-k inspired by 2-BFI scaffold to assess imidazoline molecules as D2-like dopamine receptor ligands. Conservative chemical modifications of the lead structure, such as the introduction of an hydroxy group in the aromatic ring alone or associated with N-benzyl substitution, provided partial (3f) or nearly full (3e and 3h) agonists, all endowed with D2-like potency comparable to that of dopamine.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3796O – PubChem

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A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication

Human rhinoviruses (hRVs) are the main causative pathogen for common colds and are associated with the exacerbation of asthma. The wide variety in hRV serotypes has complicated the development of rhinovirus replication inhibitors. In the current investigation, we developed a novel series of benzothiophene derivatives and their analogues (6-8) that potently inhibit the replication of both hRV-A and hRV-B strains. Compound 6g inhibited the replication of hRV-B14, A21, and A71, with respective EC50 values of 0.083, 0.078, and 0.015 muM. The results of a time-of-addition study against hRV-B14 and hRV-A16 and resistant mutation analysis on hRV-B14 implied that 6g acts at the early stage of the viral replication process, interacting with viral capsid protein. A molecular docking study suggested that 6g has a capsid-binding mode similar to that of pleconaril. Finally, derivatives of 6 also displayed significant inhibition against poliovirus 3 (PV3) replication, implying their potential inhibitory activities against other enterovirus species.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3797O – PubChem

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Efficient synthesis of chiral benzofuryl beta-amino alcohols via a catalytic asymmetric Henry reaction

Chiral beta-amino alcohol ligands were found effective for the copper(ii)-catalyzed asymmetric Henry reaction of benzofuran-2-carbaldehydes with nitromethane, which led to the formation of (S)-enriched benzofuryl beta-nitro alcohols with satisfactory enantioselectivities (up to 98% ee). Using this catalytic protocol, bioactive (S)-benzofuryl beta-amino alcohols could be conveniently prepared in short steps.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3795O – PubChem

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The chemistry of 5-oxodihydroisoxazoles. XVI* a new synthesis of pyrroles, furans, thiophens and their benzo analogues

Ethyl 5-oxo-2-phenyl-2,5-dihydroisoxazole-4-carboxylate (2) was photolysed at 300 nm in the presence of phenols, enols, anilines, enamines, aryl thiols and thioenols affording enamines. Treatment of these enamines with Lewis or protic acids gives the respective benzo and five-membered ring systems.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3800O – PubChem