Mono- and dialdehyde of trehalose: new synthons to prepare trehalose bio-conjugates was written by Greco, Valentina;Sciuto, Sebastiano;Rizzarelli, Enrico. And the article was included in Organic & Biomolecular Chemistry in 2021.Category: benzofurans This article mentions the following:
Trehalose, a non-reducing disaccharide of glucose, is a natural bioactive and non-toxic sugar. It is found in many organisms that synthesize it when their cells are exposed to stress conditions. While not produced by mammalian cells, this disaccharide and also some of its derivatives have been shown to have a number of interesting properties that indicate their importance in the treatment of certain human diseases. Differentiating the two glucosyl moieties in the trehalose mol. has often been a synthetic challenge. We report here an easy way to obtain the mono-aldehyde of trehalose, as well as the relevant sym. dialdehyde. The reactivity of the aldehyde functionalities involved in the mol. structure of these synthons allows the easy preparation of the corresponding amino or carboxy derivatives of trehalose, as well the synthesis of some new trehalose conjugates useful for diagnostic or therapeutic purposes. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Category: benzofurans).
5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Category: benzofurans