Shigemitsu, Hajime et al. published their research in Nature Communications | CAS: 92557-80-7

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Synthetic Route of C25H15NO9

Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems was written by Shigemitsu, Hajime;Kubota, Ryou;Nakamura, Keisuke;Matsuzaki, Tomonobu;Minami, Saori;Aoyama, Takuma;Urayama, Kenji;Hamachi, Itaru. And the article was included in Nature Communications.Synthetic Route of C25H15NO9 This article mentions the following:

Non-enzymic proteins including antibodies function as biomarkers and are used as biopharmaceuticals in several diseases. Protein-responsive soft materials capable of the controlled release of drugs and proteins have potential for use in next-generation diagnosis and therapies. Here, we describe a supramol./agarose hydrogel composite that can release a protein in response to a non-enzymic protein. A non-enzymic protein-responsive system is developed by hybridization of an enzyme-sensitive supramol. hydrogel with a protein-triggered enzyme activation set. In situ imaging shows that the supramol./agarose hydrogel composite consists of orthogonal domains of supramol. fibers and agarose, which play distinct roles in protein entrapment and mech. stiffness, resp. Integrating the enzyme activation set with the composite allows for controlled release of the embedded RNase in response to an antibody. Such composite hydrogels would be promising as a matrix embedded in a body, which can autonomously release biopharmaceuticals by sensing biomarker proteins. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7Synthetic Route of C25H15NO9).

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Synthetic Route of C25H15NO9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem