Luo, Huanhuan; Kong, Li; Zhang, Feng; Huang, Chenglong; Chen, Jiayi; Zhang, Hongbo; Yu, Han; Zheng, Song; Xu, Hongwei; Zhang, Yiran; Deng, Lianfu; Chen, Gang; Santos, Helder A.; Cui, Wenguo published an article in 2021. The article was titled 《Light-Controlled Nanosystem with Size-Flexibility Improves Targeted Retention for Tumor Suppression》, and you may find the article in Advanced Functional Materials.Safety of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:
Although great promise has been achieved with nanomedicines in cancer therapy, limitations are still encountered, such as short retention time in the tumor. Herein, a nanosystem that can modulate the particle size in situ by near-IR (NIR) light is self-assembled by crosslinking the surface-modified poly(lactic-co-glycolic acid) from the up-conversion nanoparticle with indocyanine green and doxorubicin-nitrobenezene-polyethylene glycol (DOX-NB-PEG). The nanosystem with its small size (100 nm) achieves better tumor targeting, while the PEG on the surface of the nanosystem can effectively shield the adsorption of proteins during blood circulation, maintaining a stable nanostructure and achieving good tumor targeting. Moreover, the nanosystem at the tumor realizes the rapid shedding of PEG on its surface by NIR irradiation, and the enhanced cellular uptake. At the same time, aggregation occurs inside the nanosystem to form bigger particles (600 nm) in situ, prolonging the retention time at the tumor and producing enhanced targeted therapeutic effects. In vitro data show higher cellular uptake and a higher rate of apoptosis after irradiation, and the in vivo data prove that the nanosystem have a longer residence time at the tumor site after NIR irradiation This nanosystem demonstrates an effective therapeutic strategy in targeted synergistic tumors. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Safety of 1,3-Diphenylisobenzofuran)
1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Safety of 1,3-Diphenylisobenzofuran
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem