Day: October 14, 2022

Yin, Juanjuan’s team published research in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2021 | CAS: 5471-63-6

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Application In Synthesis of 1,3-Diphenylisobenzofuran

Yin, Juanjuan; Jiang, Xu; Sui, Guomin; Du, Yingying; Xing, Enyun; Shi, Ruijie; Gu, Chengzhi; Wen, Xiaona; Feng, Yaqing; Shan, Zhongqiang; Meng, Shuxian published an article in 2021. The article was titled 《The tumor phototherapeutic application of nanoparticles constructed by the relationship between PTT/PDT efficiency and 2,6- and 3,5-substituted BODIPY derivatives》, and you may find the article in Journal of Materials Chemistry B: Materials for Biology and Medicine.Application In Synthesis of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

BODIPY dyes have recently been used for photothermal and photodynamic therapy of tumors. However, complex multi-material systems, multiple excitation wavelengths and the unclear relationship between BODIPY structures and their PTT/PDT efficiency are still major issues. In our study, nine novel BODIPY near-IR dyes were designed and successfully synthesized and then, the relationships between BODIPY structures and their PTT/PDT efficiency were investigated in detail. The results showed that modifications at position 3,5 of the BODIPY core with conjugated structures have better effects on photothermal and photodynamic efficiency than the modifications at position 2,6 with halogen atoms. D. functional theory (DFT) calculations showed that this is mainly due to the extension of the conjugated chain and the photoinduced electron transfer (PET) effect. By encapsulating BDPX-M with amphiphilic DSPE-PEG2000-RGD and lecithin, the obtained NPs not only show good water solubility and biol. stability, but also could act as superior agents for photothermal and photodynamic synergistic therapy of tumors. Finally, we obtained BODIPY NPs that exhibited excellent photothermal and photodynamic effects at the same time under single irradiation with an 808 nm laser (photothermal conversion efficiency: 42.76%, A/A0: ~0.05). In conclusion, this work provides a direction to design and construct phototherapeutic nanoparticles based on BODIPY dyes for tumor treatment. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Application In Synthesis of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Meng, Xiang-Zhen’s team published research in Acta Crystallographica, Section E: Crystallographic Communications in 2020 | CAS: 5471-63-6

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.COA of Formula: C20H14O

《Crystal structure of dimethyl 5-(4-ethylphenyl)-4-[(4-ethylphenyl)ethynyl]-6,11-diphenyl-1,3,6,11-tetrahydro-2H-6,11-epoxycyclopenta[a]anthracene-2,2-dicarboxylate》 was published in Acta Crystallographica, Section E: Crystallographic Communications in 2020. These research results belong to Meng, Xiang-Zhen; Cheng, Dong. COA of Formula: C20H14O The article mentions the following:

In the central fused ring system of the title compound, C51H42O5, all of the five-membered rings are in an envelope conformation. The dihedral angle between the two benzene rings in the fused ring system is 74.66 (7)°. In the crystal, mols. are linked by C-H···π interactions, forming a layer parallel to the ab plane. Each mol. acts as a double donor as well as a double acceptor of the C-H···π interactions. Hirshfeld surface anal. and two-dimensional fingerprint plots indicate that the most important contributions to the crystal packing are from H···H (61.4%) and C···H/H···C (25.3%) contacts. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6COA of Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.COA of Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rehman, Mehreen’s team published research in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2021 | CAS: 5471-63-6

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Formula: C20H14O

Rehman, Mehreen; Raza, Abida; Khan, Jamshaid Ali; Zia, M. Aslam published their research in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2021. The article was titled 《Laser Responsive Cisplatin-Gold Nano-Assembly Synergizes the Effect of Cisplatin With Compliance》.Formula: C20H14O The article contains the following contents:

Cisplatin therapy faces low bioavailability and clastogenic potential limitations. Early payload leakage of nanocarriers may impair adequate therapeutic efficacy. We propose encapsulation of cisplatin in such nanocarrier that can be externally stimulated for high payload release and enhanced toxicity at site of action. Cisplatin conjugated gold nanorods (Pt-AuNRs) have been synthesized and characterized through UV visible spectroscopy, dynamic light scattering and transmission electron microscopy. Physico-chem. characterization through X-ray photon spectrometry confirms the covalent linkage between linker and aquated cisplatin with AuNRs. Laser exposure (850 nm, CW) enabled ∼15-fold payload release from Pt-AuNRs nano-assembly, which is quite high (P < 0.0001) compared to non-stimulated conditions. The median growth inhibitory concentration (GI50) after laser exposure of Pt-AuNRs was ∼11- and 13-fold low compared to corresponding Pt-AuNRs without laser exposure and cisplatin resp., in sarcoma cells. Synergistic therapeutic difference is more significant (P < 0.01), at lower concentrations of Pt-AuNRs (0.5-10μg/mL). Pt-AuNRs photothermal therapy indicates a convincible association of over-production of reactive oxygen species (P < 0.0001) and synergistic therapeutic efficacy. Clastogenic potential is found non-significant for Pt-AuNRs (10μg/mL). Cisplatin nanoconjugate shows biocompatibility against blood cells. In conclusion, laser-stimulated Pt-AuNRs appear a promising drug delivery with synergistic toxic potential against cancer while attenuating cisplatin toxicity. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Nie, Xiaolin’s team published research in Materials Science & Engineering, C: Materials for Biological Applications in 2020 | CAS: 5471-63-6

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Synthetic Route of C20H14O

《Carbon quantum dots embedded electrospun nanofibers for efficient antibacterial photodynamic inactivation》 was written by Nie, Xiaolin; Wu, Shuanglin; Mensah, Alfred; Lu, Keyu; Wei, Qufu. Synthetic Route of C20H14O And the article was included in Materials Science & Engineering, C: Materials for Biological Applications in 2020. The article conveys some information:

Faced with the emergence and proliferation of antibiotic resistant pathogens, novel nonspecific materials and approaches are required. Herein, we employed electrospinning technol. to fabricate nanofibers with antibacterial photodynamic inactivation. This material combines polyacrylonitrile, as a photostable polymer, and biocompatible carbon quantum dots. The resulted nanofibers were successfully characterized by phys. and spectroscopic methods. The microbicidal reactive oxygen species (i.e., singlet oxygen) upon illumination was confirmed, and cytotoxicity assay demonstrated that the nanofibers had low cytotoxicity and good biocompatibility. Antibacterial photodynamic inactivation studies demonstrated broad antibacterial efficacy of Gram-neg. Escherichia coli ATCC-8099 (99.9999+%, 6 log units inactivation), Gram-neg. Pseudomonas aeruginosa CMCC (B) 10104 (99.9999+%, 6 log units inactivation), and Gram-pos. Bacillus subtilis CMCC (B) 63501 (99.9999+%, 6 log units inactivation) upon illumination with visible light (Xe lamp, 500 W, 12 cm sample distance). However modest inactivation results were observed against Gram-pos. Staphylococcus aureus ATCC-6538 (98.3%, 1.8 log units inactivation). Owing to the prepared nanofibers exhibiting efficient antibacterial activity against Gram-neg. and Gram-pos. bacteria, such materials could be potentially used in anti-infective therapy. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Synthetic Route of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Synthetic Route of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Accomasso, Davide’s team published research in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2021 | CAS: 5471-63-6

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Application In Synthesis of 1,3-Diphenylisobenzofuran

Application In Synthesis of 1,3-DiphenylisobenzofuranIn 2021 ,《Singlet fission in covalent dimers of methylene-locked 1,3-diphenyl-isobenzofuran: semiclassical simulations of nonadiabatic dynamics》 was published in Journal of Materials Chemistry A: Materials for Energy and Sustainability. The article was written by Accomasso, Davide; Granucci, Giovanni; Persico, Maurizio. The article contains the following contents:

We present surface hopping simulations of the nonadiabatic dynamics in three covalently bound dimers of the methylene-locked 1,3-diphenylisobenzofuran (ML-DPBF) chromophore, a modification of a mol. previously studied exptl. and computationally by Michl et al. (J. C. Johnson and J. Michl, Top. Curr. Chem. (Z), 2017, 375, 80). Our aim is to test the suitability for singlet fission of such dimers, as well as to study how the singlet fission dynamics is affected by the mutual arrangement of chromophores in the covalent assembly. Two of our investigated covalent dimers, namely D1 and D2, are newly designed dimers in which the chromophores are linked by two bridges so as to attain suitable stacking arrangements, while the third one (D0) is a linear dimer in which one -CH2- bridge connects the two chromophore units. From our simulations it turned out that D1 and D2 undergo singlet fission in a sub-picosecond time scale. The final populations of the double triplet state (TT) are large (0.74 and 0.84, resp.), but do not reach the limiting value of 1 because of a persistent exchange with the lowest dark excitonic state. On the other hand, our simulations for D0 indicate that this dimer does not undergo singlet fission in the 4 ps following the photoexcitation, mainly because of the weak interaction between chromophores. Our study, besides indicating the potential suitability for singlet fission of dimers D1 and D2, highlights the impact of the mutual arrangement of chromophores in determining the singlet fission efficiency. In fact, we show the importance of fine tuning not only the effective couplings that permit to populate the TT state, but also the exciton splitting of the lowest singlet states. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Application In Synthesis of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Lei, Zhen-Yao’s team published research in Organic & Biomolecular Chemistry in 2022 | 531-88-4

Organic & Biomolecular Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent) (alkenyl). 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Formula: C10H10O4.

Lei, Zhen-Yao; Hu, Kui; He, Yuan-Xiang; Geng, Shu; Chen, Li-Na; Zou, Shuai; Pan, Li; Ding, Zhi-Jun; Huang, Feng published the artcile< Visible light-induced N-radical 5-exo/6-endo cyclization of alkenyl amides: facile access to isoindolinones/isoquinolinones>, Formula: C10H10O4, the main research area is isoindolinone isoquinolinone preparation; alkenyl amide visible light radical cyclization.

An efficient N-centered radical intramol. cyclization reaction of alkenyl amides induced by visible light was described. In this process, an alkenyl amide underwent 5-exo/6-endo cyclization to selectively yield two critical alkaloid structures, namely isoindolinones and isoquinolinones.

Organic & Biomolecular Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent) (alkenyl). 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Formula: C10H10O4.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Li, Junxuan’s team published research in Science China: Chemistry in 2022-01-31 | 531-88-4

Science China: Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, SDS of cas: 531-88-4.

Li, Junxuan; Zhou, Jinlei; Wang, Yumei; Yu, Yue; Liu, Qiang; Yang, Tilong; Chen, Huoji; Cao, Hua published the artcile< Mechanistic insight into the synergistic Cu/Pd-catalyzed carbonylation of aryl iodides using alcohols and dioxygen as the carbonyl source>, SDS of cas: 531-88-4, the main research area is aryl iodide alc carbonylation dioxygen carbonyl source mechanistic insight.

Pd-catalyzed carbonylation, as an efficient synthetic approach for the installation of carbonyl groups in organic compounds, has been one of the most important research fields in the past decade. Although elegant reactions that allow highly selective carbonylations have been developed, straightforward routes with improved reaction activity and broader substrate scope remain long-term challenges for new practical applications. Here, authors show a new type of synergistic Cu/Pd-catalyzed carbonylation reaction using alcs. and dioxgen as the carbonyl sources. A broad range of aryl iodides and alcs. are compatible with this protocol. The reaction is concise and practical due to the ready availability of the starting materials and the scalability of the reaction. In addition, the reaction affords lactones and lactams in an intermol. fashion. Moreover, DFT calculations have been performed to study the detailed mechanisms.

Science China: Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, SDS of cas: 531-88-4.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cao, Zhongcheng’s team published research in Bioorganic & Medicinal Chemistry in 2021-04-01 | 531-88-4

Bioorganic & Medicinal Chemistry published new progress about Alzheimer disease. 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Computed Properties of 531-88-4.

Cao, Zhongcheng; Song, Qing; Yu, Guangjun; Liu, Zhuoling; Cong, Shiqing; Tan, Zhenghuai; Deng, Yong published the artcile< Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease>, Computed Properties of 531-88-4, the main research area is benzylidene benzyl phthalide Mannich base preparation Alzheimers disease treatment; 3-benzylidene/benzylphthalide Mannich base derivatives; AChE inhibitors; Alzheimer’s disease; Antioxidants; MAO-B inhibitors; Multifunctional anti-AD agents.

To discover novel multifunctional agents for the treatment of Alzheimer’s disease, a series of 3-benzylidene/benzylphthalide Mannich base derivatives were designed, synthesized and evaluated. The biol. screening results indicated that most of these derivatives exhibited good multifunctional activities. Among them, compound (Z)-13c (I) raised particular interest because of its excellent multifunctional bioactivities. It displayed excellent EeAChE and HuAChE inhibition (IC50 = 9.18 x 10-5 and 6.16 x 10-4 μM, resp.), good MAO-B inhibitory activity (IC50 = 5.88μM) and high antioxidant activity (ORAC = 2.05 Trolox equivalent). Addnl., it also exhibited good antiplatelet aggregation activity, moderate self- and Cu2+-induced Aβ1-42 aggregation inhibitory potency, disaggregation ability on Aβ1-42 fibrils, biometal chelating ability, appropriate BBB permeability and significant neuroprotective effect. Furthermore, (Z)-13c can also ameliorate the learning and memory impairment induced by scopolamine in mice. These multifunctional properties highlight compound (Z)-13c as a promising candidate for further development of multifunctional drug against AD.

Bioorganic & Medicinal Chemistry published new progress about Alzheimer disease. 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Computed Properties of 531-88-4.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Takakura, Ryoya’s team published research in Synlett in 2019-10-31 | 531-88-4

Synlett published new progress about Glycols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Category: benzofurans.

Takakura, Ryoya; Ban, Kazuho; Sajiki, Hironao; Sawama, Yoshinari published the artcile< Platinum-on-Carbon-Catalyzed Aqueous Oxidative Lactonization of Diols by Using Molecular Oxygen>, Category: benzofurans, the main research area is lactone preparation green chem; diol oxidative lactonization platinum catalyst.

A lactonization of various diols e.g., I catalyzed by platinum on carbon (Pt/C) in water under an atm. of mol. oxygen was developed. Diols e.g., I were transformed into lactones e.g., II by the present oxidative lactonization method.

Synlett published new progress about Glycols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ye, Chanyuan’s team published research in Bioorganic Chemistry in 2021-06-30 | 531-88-4

Bioorganic Chemistry published new progress about Alzheimer disease. 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Application of C10H10O4.

Ye, Chanyuan; Xu, Rui; Cao, Zhongcheng; Song, Qing; Yu, Guangjun; Shi, Yichun; Liu, Zhuoling; Liu, Xiuxiu; Deng, Yong published the artcile< Design, synthesis, and in vitro evaluation of 4-aminoalkyl-1(2H)-phthalazinones as potential multifunctional anti-Alzheimer's disease agents>, Application of C10H10O4, the main research area is aminoalkylphthalazinone preparation cholinesterase inhibitor SAR antioxidant neuroprotective Alzheimer disease; 4-(aminoalkyl)-1(2H)-phthalazinone derivatives; Acetylcholinesterase inhibitors; Alzheimer’s disease; Anti-neuroinflammation; Aβ aggregation inhibitors; Monoamine oxidases inhibitors; Multifunctional agents.

A series of 4-aminoalkyl-1(2H)-phthalazinone derivatives I (R1 = benzyl, 2-methoxybenzyl, 2-dimethylaminobenzyl, 4-dimethylaminobenzyl, ethyl; R2 = Me, Et; R1R2 = -(CH2)5-, -(CH2)2O(CH2)2-, -(CH2)2N(CH3)(CH2)2-; n = 1, 3, 5) was designed and synthesized as potential multifunctional agents for Alzheimer’s disease (AD) treatment. In vitro biol. assay results demonstrated that most synthesized compounds I exhibited significant AChE inhibition, moderate to high monoamine oxidases (MAO) inhibitory potencies and good anti-platelet aggregation abilities. Among them, compound I (R1 = Bn; R2 = Et; n = 3) (II) exhibited the highest inhibitory potencies towards MAO-B and MAO-A (IC50 = 0.7μM and 6.4μM resp.), moderate inhibition towards AChE (IC50 = 8.2μM), and good activities against self- and Cu2+-induced Aβ1-42 aggregation and platelet aggregation. Moreover, II also displayed antioxidant capacity, neuroprotective potency, anti-neuroinfammation and BBB permeability. These excellent results indicated that compound II could be worthy of further studies to be considered as a promising multifunctional candidate for the treatment of AD.

Bioorganic Chemistry published new progress about Alzheimer disease. 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Application of C10H10O4.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem