On March 22, 2012, Smith, Nicholas D.; Kahraman, Mehmet; Govek, Steven P.; Nagasawa, Johnny Y.; Lai, Andiliy G.; Julien, Jackaline D.; Herbert, Mark R.; Bonnefous, Celine; Douglas, Karensa L. published a patent.Computed Properties of 60770-67-4 The title of the patent was Preparation of substituted 3-[4-[1-(1H-indazol-5-yl)-2-phenylvinyl]phenyl]acrylic acid, derivatives and analogs as estrogen receptor modulators. And the patent contained the following:
The invention is related to the preparation of title compounds I [A =indanyl, indenyl, 8-10 membered bicyclic hetercyclic, etc.; B, C = independently Ph, naphthyl, 5-6 membered monocyclic heteroaryl, etc.; R1 = tetrazolyl, pyrrolidinyl, aminocycloalkyl, etc.; R2 = halo, CN, nO2, alkoxy, etc.; R3-4 = independently at each occurrence H, CN, OH, (un)substituted fluoroalkyl, Ph, etc; m, n, p = independently 0-4], their pharmaceutically acceptable salts and N-oxides as estrogen receptor modulators and to pharmaceutical compositions containing them. Thus, (E)-3-[4-[(E)-1-(1H-Indazol-5-yl)-2-phenylbut-1-en-1-yl]phenyl]-2-propenoic acid (II) was prepared via reaction of 5-(1-butyn-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (preparation given) with iodobenzene and (E)-[4-(3-ethoxy-3-oxoprop-1-en-1-yl)phenyl]boronic acid. II displayed an IC50 ≤ 100 nM in the MCF7 viability assay. I may be useful for the treatment of diseases or conditions that are mediated by or dependent upon estrogen receptors such as cancer, central nervous system (CNS) defects, cardiovascular system defects, hematol. system defects, immune and inflammation diseases, susceptibility to infection, metabolic defects, neurol. defects, psychiatric defects and reproductive defects. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Computed Properties of 60770-67-4
The Article related to indazolyl phenylvinylphenylacrylic acid preparation estrogen receptor modulator cancer cardiovascular, quinoxalinyl benzothiazolyl indazolyl triazolopyridinyl oxoisoindolinyl phenylvinylphenylacrylic acid phenylvinylphenylacrylamide preparation and other aspects.Computed Properties of 60770-67-4
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem