So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Solberg, Claus O.; Allred, Craig D.; Hill, Harry R. researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.They published the article 《Influence of phenylbutazone on leukocyte chemiluminescence and function》 about this compound( cas:129-18-0 ) in Acta Pathologica et Microbiologica Scandinavica, Section C: Immunology. Keywords: phenylbutazone leukocyte chemiluminescence. We’ll tell you more about this compound (cas:129-18-0).
The effect of Na phenylbutazone (I Na salt) [129-18-0] on human leukocyte chemiluminescence, phagocytosis and intracellular killing of bacteria was examined A marked reduction of chemiluminescence and intracellular killing of bacteria was observed The effect on phagocytosis was less pronounced. High drug concentrations nearly abolished light emission, and concentrations equivalent to those obtained in plasma during therapy caused a 25-30% reduction The effect occurred within less than 10 min after I administration. No permanent effect upon resting cells was observed I reduced the effect of Na azide on leukocyte chemiluminescence, indicating that the drug might also inhibit myeloperoxidase dependent chemiluminescence. Whether these impairments of leukocyte function also take place in vivo resulting in enhanced susceptibility to infection remains unknown.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem