On February 20, 2003, Gerlach, Matthias; Przewosny, Michael; Englberger, Werner Guenter; Reissmueller, Elke; Bloms-Funke, Petra; Maul, Corinna; Jagusch, Utz-Peter published a patent.Name: 5-Iodobenzofuran The title of the patent was Preparation of 5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzo[c]fluoren-6-carboxylic acids as NMDA antagonists for the treatment of pain. And the patent contained the following:
Title compounds I [R1, R2, R3, R4 = H, halo, CN, etc.; R5 = H, alkyl, alkenyl, etc.; R6 = R12, ZR12; R12 = H, alkyl, alkenyl, etc.; Z = (un)substituted alkyl, alkenyl, alkynyl; R7, R8, R9, R10 = H, halo, CN, etc.] and their pharmaceutically acceptable salts were prepared For example, acid catalyzed three-component coupling of benzofuran, oxoacetic acid and 3,5-dichlorobenzenamine provided claimed benzo[c]fluorene II (no data provided). In glycine binding site studies of the NMDA receptor channel, one specific example of compound I, benzo[c]fluorene II exhibited a Ki = 0.053 μM. Compounds I are claimed useful as analgesic agents for the treatment of pain. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Name: 5-Iodobenzofuran
The Article related to preparation benzofluorenecarboxylic acid analgesic agent pain, benzofluorenecarboxylic acid preparation nmda antagonist glutamate receptor, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Name: 5-Iodobenzofuran
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem