On February 4, 2020, Mao, Jianyou; Ling, Bo; Yang, Wenjun published a patent.Name: 5-Iodobenzofuran The title of the patent was Synthetic method of β,β-disubstituted propionate derivatives from aldehyde, iodide and alcohol by one-pot process. And the patent contained the following:
The invention is related to the synthetic method of β,β-disubstituted propionate derivatives from aldehyde, iodide and alc. by one-pot process. The title method includes subjecting aldehyde (cinnamaldehyde, 3-(4-chloro-phenyl)-propenal, etc.), iodide (iodobenzene, 4-tert-butyliodobenzene, etc.) and alc. (methanol, etc.) to a one-pot process in the presence of catalyst (N-heterocyclic carbene catalysts (1,3-bis(2, 6-diisopropylphenyl)imidazolium chloride, 1,3-dicyclohexyl-imidazolium chloride, etc.) and transition metal catalysts (tetrakis(triphenylphosphine)palladium, palladium acetate, etc.)), strong base (potassium methoxide, cesium carbonate, etc.) and ligand (2,2′:6′,2”-terpyridine, L6, etc.) to obtain the β,β-disubstituted propionate derivatives (Me 3,3-diphenylpropionate, Me 3-naphthalen-1-yl-3-phenyl-propionate, etc.). The method realizes the arylation of β-position and the esterification of carbonyl of α,β-unsaturated aldehydes to synthesize Me β,β-disubstituted propionate. The method reduces the synthetic steps of the conventional process, improves the reaction yield, has the advantages of cheap raw materials, simple operation steps and mild reaction conditions, and greatly enriches the applicability of the substrate for the reaction. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Name: 5-Iodobenzofuran
The Article related to synthetic disubstituted propionate derivative aldehyde iodide alc, Aliphatic Compounds: Esters, Linear Anhydrides, Acyl Peroxides, and Acyl Halides and other aspects.Name: 5-Iodobenzofuran
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem