On July 26, 2021, Boehm, Philip; Martini, Tristano; Lee, Yong Ho; Cacherat, Bastien; Morandi, Bill published an article.Recommanded Product: 5-Iodobenzofuran The title of the article was Palladium-Catalyzed Decarbonylative Iodination of Aryl Carboxylic Acids Enabled by Ligand-Assisted Halide Exchange. And the article contained the following:
An efficient and broadly applicable palladium-catalyzed iodination of inexpensive and abundant aryl and vinyl carboxylic acids via in situ activation to the acid chloride and formation of a phosphonium salt is reported. The use of 1-iodobutane as iodide source in combination with a base and a deoxychlorinating reagent gives access to a wide range of aryl and vinyl iodides under Pd/Xantphos catalysis, including complex drug-like scaffolds. Stoichiometric experiments and kinetic anal. suggest a unique mechanism involving C-P reductive elimination to form the Xantphos phosphonium chloride, which subsequently initiates an unusual halogen exchange by outer sphere nucleophilic substitution. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Recommanded Product: 5-Iodobenzofuran
The Article related to aryl vinyl carboxylic acid decarbonylative iodination palladium catalyst, iodination, ligand non-innocence, palladium, reaction mechanism, shuttle catalysis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Recommanded Product: 5-Iodobenzofuran
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem