On December 16, 2021, Andrews, Mark; Soerensen, Morten Dahl; Larsen, Mogens; Devaux, Nicolas; Barros Ribeiro da Silva, Vicinius; Perron, Quentin; Liang, Xifu; Seitzberg, Jimmi Gerner published a patent.Recommanded Product: 29735-85-1 The title of the patent was N-Heteroaryl and N-aryl amidoamides as small molecule modulators of IL-17 and their preparation. And the patent contained the following:
The invention relates to a compound according to formula I and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments. Compounds of formula I wherein X, Y, Z and V are independently N, CH and CR4; R1 is (un)substituted C1-4 alkyl, (un)substituted C3-7 cycloalkyl, C1-6 alkoxy, (un)substituted Ph, etc.; R2 is (un)substituted 5- to 6-membered heteroaryl; R3 is CHR5R6, (un)substituted C3-10 cycloalkyl, (un)substituted tetrahydronaphthyl, etc.; R4 is (un)substituted C1-6 alkyl, (un)substituted C1-6 alkoxy, OH, NH2 and halo; R5 and R6 are independently H, (un)substituted Ph, (un)substituted C1-6 alkyl, (un)substituted C3-7 cycloalkyl, etc.; and pharmaceutically acceptable salts, hydrates and solvates thereof, are claimed. Example compound II was prepared by deprotection of N-[(1S)-1-(dicyclopropylmethyl)-2-[[5-[3,5-dimethyl-1-(2-trimethylsilylethoxymethyl)pyrazol-4-yl]-6-fluoro-2-pyridyl]amino]-2-oxo-ethyl]-2-isopropylpyrazole-3-carboxamide. The invention compounds were evaluated for their IL-17 modulatory activity. From the assay, it was determined that compound II exhibited EC50 value of 15 nM. The experimental process involved the reaction of 5-Hydroxybenzofuran-3-carboxylic acid(cas: 29735-85-1).Recommanded Product: 29735-85-1
The Article related to heteroaryl aryl amidoamide preparation il17 modulator, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 29735-85-1
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem