Day: October 20, 2022

《Perfluoropolyether nanoemulsion encapsulating chlorin e6 for sonodynamic and photodynamic therapy of hypoxic tumor》 was written by Hong, Liang; Pliss, Artem M.; Zhan, Ye; Zheng, Wenhan; Xia, Jun; Liu, Liwei; Qu, Junle; Prasad, Paras N.. Application of 5471-63-6 And the article was included in Nanomaterials in 2020. The article conveys some information:

Sonodynamic therapy (SDT) has emerged as an important modality for cancer treatment. SDT utilizes ultrasound excitation, which overcomes the limitations of light penetration in deep tumors, as encountered by photodynamic therapy (PDT) which uses optical excitations. A comparative study of these modalities using the same sensitizer drug can provide an assessment of their effects. However, the efficiency of SDT and PDT is low in a hypoxic tumor environment, which limits their applications. In this study, we report a hierarchical nanoformulation which contains a Food and Drug Administration (FDA) approved sensitizer chlorin, e6, and a uniquely stable high loading capacity oxygen carrier, perfluoropolyether. This oxygen carrier possesses no measurable cytotoxicity. It delivers oxygen to overcome hypoxia, and at the same time, boosts the efficiency of both SDT and PDT. Moreover, we comparatively analyzed the efficiency of SDT and PDT for tumor treatment throughout the depth of the tissue. Our study demonstrates that the strengths of PDT and SDT could be combined into a single multifunctional nanoplatform, which works well in the hypoxia environment and overcomes the limitations of each modality. The combination of deep tissue penetration by ultrasound and high spatial activation by light for selective treatment of single cells will significantly enhance the scope for therapeutic applications. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Application of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Related Products of 5471-63-6In 2021 ,《Supramolecular Tadalafil Nanovaccine for Cancer Immunotherapy by Alleviating Myeloid-Derived Suppressor Cells and Heightening Immunogenicity》 was published in Small Methods. The article was written by Zhang, Tian; Xiong, Honggang; Ma, Xianbin; Gao, Yuan; Xue, Peng; Kang, Yuejun; Sun, Zhi-Jun; Xu, Zhigang. The article contains the following contents:

Tumor-induced immune suppression mediated by myeloid-derived suppressor cells (MDSCs) and insufficient immunogenicity are two major factors for the poor overall response rate to the immune checkpoint blockade (ICB). Here, a tumor microenvironment responsive nanoprodrug (FIT nanoparticles) is presented for co-delivering tadalafil (TAD) and indocyanine green (ICG) photosensitizer to simultaneously targeting intratumor MDSCs and amplifying tumor immunogenicity. The resulting nanoprodrug shows high drug loading (nearly 100%), tumor-specific release, and robust therapeutic efficacy by virtue of promoting immunogenic cell death (ICD) induction and alleviation of MDSCs for augmenting the photothermal immunotherapy. In an in vivo colon tumor model, the released TAD in the tumor can effectively ameliorate MDSCs immunosuppressive activity, while the photosensitizer ICG is capable of inducing ICD to promote sufficient dendritic cells maturation and T cell infiltration. The results reported here may provide a superior candidate of adjuvants for strengthening immune response and ICB efficacy.1,3-Diphenylisobenzofuran(cas: 5471-63-6Related Products of 5471-63-6) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Related Products of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Construction of FRET-Based Off-On Fluorescent Nanoprobes for Sensitive Detection of Intracellular Singlet Oxygen》 was written by Ping, Jian-tao; Qin, Jing-lei; Zhou, Chao; Guo, Lan-ying; Liu, Bei; Chen, Zhi-hua; Geng, Zhao-xin; Peng, Hong-shang. Computed Properties of C20H14O And the article was included in ChemNanoMat in 2020. The article conveys some information:

Singlet oxygen (1O2) detection remains an active area of research in the field of biol. and biomedical science. In this work, we reported a novel Off-On type FRET-based fluorescent 1O2 nanoprobe comprising the energy-donating conjugated polymer, poly(9,9-dioctylfluorenyl-2,7-diyl) (PFO), and the energy-accepting 1O2 indicator, 3-diphenylisobenzofuran (DPBF). Prior to the reaction with 1O2, the nanoprobe was in Off-state because fluorescence of PFO was completely quenched by loaded DPBF; in the presence of 1O2, it switched to On-state due to the depletion of DPBF. The as-prepared 1O2 nanoprobe had a particle size of ~59 nm, good biocompatibility, high specificity and sensitivity with a limit of detection of 353 nM. Importantly, the fluorescent nanoprobes were highly sensitive to 1O2 under two-photon excitation. Using a multiphoton confocal microscope, generation of intracellular 1O2 during photodynamic therapy was sensitively detected by recording fluorescence intensity of the nanoprobes. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wei, Fangmian; Kuang, Shi; Rees, Thomas W.; Liao, Xinxing; Liu, Jiangping; Luo, Diqing; Wang, Jinquan; Zhang, Xiting; Ji, Liangnian; Chao, Hui published an article in 2021. The article was titled 《Ruthenium(II) complexes coordinated to graphitic carbon nitride: Oxygen self-sufficient photosensitizers which produce multiple ROS for photodynamic therapy in hypoxia》, and you may find the article in Biomaterials.Synthetic Route of C20H14O The information in the text is summarized as follows:

The photodynamic therapy (PDT) of cancer is limited by tumor hypoxia as PDT efficiency depends on O2 concentration A novel oxygen self-sufficient photosensitizer (Ru-g-C3N4) was therefore designed and synthesized via a facile one-pot method in order to overcome tumor hypoxia-induced PDT resistance. The photosensitizer is based on [Ru(bpy)2]2+ coordinated to g-C3N4 nanosheets by Ru-N bonding. Compared to pure g-C3N4, the resulting nanosheets exhibit increased water solubility, stronger visible light absorption, and enhanced biocompatibility. Once Ru-g-C3N4 is taken up by hypoxic tumor cells and exposed to visible light, the nanosheets not only catalyze the decomposition of H2O2 and H2O to generate O2, but also catalyze H2O2 and O2 concurrently to produce multiple ROS (·OH, ·O-2, and 1O2). In addition, Ru-g-C3N4 affords luminescence imaging, while continuously generating O2 to alleviate hypoxia greatly improving PDT efficacy. To the best of our knowledge, this oxygen self-sufficient photosensitizer produced via grafting a metal complex onto g-C3N4 is the first of its type to be reported. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Synthetic Route of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Synthetic Route of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Liu, Ting; Zhang, Honglin; Zhang, Xiyu; Zhao, Hua; Zhang, Zhiguo; Tian, Ye published an article in 2021. The article was titled 《The effect of imidazole on the singlet oxygen quantum yield of sinoporphyrin sodium》, and you may find the article in Chemical Physics.Related Products of 5471-63-6 The information in the text is summarized as follows:

In this paper, the effect of imidazole on the singlet oxygen quantum yield (ΦΔ) of sinoporphyrin sodium (DVDMS) was studied. A relative method was used to measure ΦΔ with Rose Bengal (RB) as the reference and 1,3-diphenylisobenzofuran (DPBF) as the singlet oxygen trapping reagent. It can be found that ΦΔ of DVDMS decreased with the increment of imidazole concentration, and kept 0.33 after the imidazole concentration was above 0.26 M. The process of 1O2 generation and optical properties of DVDMS in different imidazole concentrations were studied to analyze the reason for the above behavior. The invariability of UV-vis absorption and photoluminescence spectra suggested that the reduction of ΦΔ was attributed to the decrease of interaction between DVDMS and O2, which was caused by the surrounding of imidazole on DVDMS. For efficient implementation of PDT, it is necessary to identify the factors that may reduce the effect of PDT. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Related Products of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Related Products of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zhang, Jiayin; Wang, Qiyu; Hong, Liang; Song, Guoli; Zhang, Zhiguo published an article in 2021. The article was titled 《Optimal fluorescence and photosensitivity properties of dual-functional NaYb1-xF4:Tmx3+ nanoparticles for applications in imaging guided photodynamic therapy》, and you may find the article in RSC Advances.Formula: C20H14O The information in the text is summarized as follows:

The fluorescence and photosensitivity properties of NaYb1-xF4:Tmx3+ nanoparticles were optimized to develop noninvasive near-IR fluorescence imaging-guided photodynamic therapy. The emission at 800 nm from Tm3+ presented an exponential increase with an increase in the Tm3+ doping concentration from 0 to 2%. The photosensitivity properties of NaYb1-xF4:Tmx3+ nanoparticles were also studied via the chemoprobe method, which used a reactive oxygen quencher, 1,3-diphenylisobenzofuran (DPBF). With the increase in the doping concentration of Tm3+, the generation rate of reactive oxygen species in NaYb1-xF4:Tmx3+ nanoparticles decreased linearly at a rate of 0.3. The doping concentration of Tm3+ had two opposite effects on the 800 nm emission and generation rates of reactive oxygen species. The competitive relationship was discussed and an optimal value for the Tm3+ doping concentration of approx. 1% was determined At this concentration, the energy of the Yb3+ excited state can be fully utilized, and the fluorescence and photosensitivity properties are an effective combination. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Xiong, Tao; Li, Mingle; Chen, Yingchao; Du, Jianjun; Fan, Jiangli; Peng, Xiaojun published their research in Chemical Science in 2021. The article was titled 《A singlet oxygen self-reporting photosensitizer for cancer phototherapy》.COA of Formula: C20H14O The article contains the following contents:

Photodynamic cancer therapy has attracted great attention with the increasing threat of tumors, and improving its therapeutic efficacy is highly desirable. However, due to the highly efficient intersystem crossing potency to generate singlet oxygen (1O2), high-efficiency photosensitizers often suffer from weak fluorescence and excess injury to normal tissue. To overcome these obstacles, here we show a reliable self-reporting strategy for real-time monitoring of therapeutic progression. As a proof of concept, a mol. dyad is designed by connecting benzo[a]phenoselenazinium (NBSe) to rhodamine (Rh), namely Rh-NBSe, where the fluorescence of the Rh unit is initially suppressed by the fluorescence resonance energy transfer mechanism, but enabled to recover as feedback signal once the reaction with photosensitized 1O2 takes place. The observed fluorescence increases by irradiation in vitro and in vivo successfully reflect the real-time 1O2 generation speed in photodynamic therapy. In addition, the favorable therapeutic advantages of Rh-NBSe are also verified, for example, the high ΦΔ (0.8) and the low IC50 (0.2 μM, 6 J cm-2). Based on the therapeutic ability and real-time 1O2 self-reporting ability, Rh-NBSe demonstrates significant potential for self-regulating phototherapy. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6COA of Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.COA of Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 2022,Yang, Le; Chua, Xian Wei; Yang, Zhihong; Ding, Xiangpeng; Yu, Yong; Suwardi, Ady; Zhao, Meng; Ke, Karen Lin; Ehrler, Bruno; Di, Dawei published an article in Nanoscale Advances. The title of the article was 《Photon-upconverters for blue organic light-emitting diodes: a low-cost, sky-blue example》.Formula: C20H14O The author mentioned the following in the article:

In the research ecosystem’s quest towards having deployable organic light-emitting diodes with higher-energy emission (e.g., blue light), we advocate focusing on fluorescent emitters, due to their relative stability and color purity, and developing design strategies to significantly improve their efficiencies. We propose that all triplet-triplet annihilation upconversion (TTA-UC) emitters would make good candidates for triplet fusion-enhanced OLEDs (“”FuLEDs””), due to the energetically uphill nature of the photophys. process, and their common requirements. We demonstrate this with the low-cost sky-blue 1,3-diphenylisobenzofuran (DPBF). Having satisfied the criteria for TTA-UC, we show DPBF as a photon upconverter (Ith 92 mW cm-2), and henceforth demonstrate it as a bright emitter for FuLEDs. Notably, the devices achieved 6.5% external quantum efficiency (above the ∼5% threshold without triplet contribution), and triplet-exciton-fusion-generated fluorescence contributes up to 44% of the electroluminescence, as shown by transient measurements. Here, triplet fusion translates to a quantum yield (φ TTA-UC) of 19%, at an elec. excitation of ∼0.01 mW cm-2. The enhancement is meaningful for com. blue OLED displays. We also found DPBF to have decent hole mobilities of ∼0.08 cm2 V-1 s-1. This addnl. finding can lead to DPBF being used in other capacities in various printable electronics. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Erbing, Elis; Sanz-Marco, Amparo; Vazquez-Romero, Ana; Malmberg, Jesper; Johansson, Magnus J.; Gomez-Bengoa, Enrique; Martin-Matute, Belen published an article on February 2 ,2018. The article was titled 《Base- and Additive-Free Ir-Catalyzed ortho-Iodination of Benzoic Acids: Scope and Mechanistic Investigations》, and you may find the article in ACS Catalysis.Application In Synthesis of 7-Iodoisobenzofuran-1(3H)-one The information in the text is summarized as follows:

A protocol for the C-H activation/iodination of benzoic acids catalyzed by a simple iridium complex has been developed. The method described in this paper allows the ortho-selective iodination of a variety of benzoic acids under extraordinarily mild conditions in the absence of any additive or base in 1,1,1,3,3,3-hexafluoroisopropanol as the solvent. The iridium catalyst used tolerates air and moisture, and selectively gives ortho-iodobenzoic acids with high conversions. Mechanistic investigations revealed that an Ir(III)/Ir(V) catalytic cycle operates, and that the unique properties of HFIP enables the C-H iodination using the carboxylic moiety as a directing group. After reading the article, we found that the author used 7-Iodoisobenzofuran-1(3H)-one(cas: 105694-46-0Application In Synthesis of 7-Iodoisobenzofuran-1(3H)-one)

7-Iodoisobenzofuran-1(3H)-one(cas: 105694-46-0) belongs to benzofurans.Application In Synthesis of 7-Iodoisobenzofuran-1(3H)-oneBenzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 2012,RSC Advances included an article by Song, Wen-Jian; Yang, Xiao-Dong; Zeng, Xiang-Hui; Xu, Xiao-Liang; Zhang, Gao-Lan; Zhang, Hong-Bin. HPLC of Formula: 50551-57-0. The article was titled 《Synthesis and cytotoxic activities of novel hybrid compounds of imidazole scaffold-based 2-substituted benzofurans》. The information in the text is summarized as follows:

A series of novel hybrid compounds between 2-substituted benzofuran and imidazole have been prepared and evaluated in vitro against a panel of human tumor cell lines. The results show that the hybrid compounds were more selective towards an ovarian carcinoma cell line (Skov3-3) and suggest that hybrid compounds bearing 2-substituted benzofuran and benzimidazole moieties, as well as imidazolium salts, were vital for modulating cytotoxic activity. Two 2-substituted benzofuran imidazole hybrids may serve as valuable leads for further structural modifications. The title compounds thus formed included 1-[(2-benzofuranyl)methyl]-3-(phenylmethyl)-1H-benzimidazolium bromide (I) and related substances, such as [(benzofuranyl)methyl]imidazole derivatives The synthesis of the target compounds was achieved by a reaction of imidazole derivatives with 2-benzofuranmethanol. In the experimental materials used by the author, we found Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0HPLC of Formula: 50551-57-0)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.HPLC of Formula: 50551-57-0Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem