Day: October 20, 2022

In 2022,Deng, Yi; Shi, Jiacheng; Chan, Yau Kei; Bai, Ding; Shu, Rui; Shi, Xiuyuan; Li, Yunfei; Li, Limei; Yang, Xiao; Yang, Weizhong published an article in Advanced Healthcare Materials. The title of the article was 《Heterostructured Metal-Organic Frameworks/Polydopamine Coating Endows Polyetheretherketone Implants with Multimodal Osteogenicity and Photoswitchable Disinfection》.Recommanded Product: 5471-63-6 The author mentioned the following in the article:

Clin., bacteria-induced contagion and insufficient osseointegrative property inevitably elicit the failure of orthopedic implants. Herein, a heterostructured coating consisting of simvastatin (SIM)-laden metal-organic frameworks and polydopamine nanolayers is created on a porous bioinert polyetheretherketone implant. The heterostructured coating significantly promotes cytocompatibility and osteogenic differentiation through multimodal osteogenicity mechanisms of zinc ion (Zn2+) therapy, SIM drug therapy, and surface micro-/nano-topol. stimulation. Under the illumination of near-IR (NIR) light, singlet oxygen (1O2) and local hyperthermia are produced; besides, NIR light dramatically accelerates the release of Zn2+ ions from heterostructured coatings. Gram-pos. and -neg. bacteria are effectively eradicated by the synergy of photothermal/photodynamic effects and photo-induced accelerated delivery of Zn2+ ions. The superior osteogenicity and osseointegration, as well as photoswitchable disinfection controlled by NIR light are corroborated via in vivo results. This work highlights the great potential of photoresponsive heterostructured orthopedic implants in treatment of the noninvasive bone reconstruction of bacteria-associated infectious tissues through multimodal phototherapy and photoswitchable ion-therapy. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Recommanded Product: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Assemblies of indocyanine green and chemotherapeutic drug to cure established tumors by synergistic chemo-photo therapy》 was published in Journal of Controlled Release in 2020. These research results belong to Hu, Shiqi; Dong, Chengyuan; Wang, Jinqiang; Liu, Kexin; Zhou, Quan; Xiang, Jiajia; Zhou, Zhuxian; Liu, Fusheng; Shen, Youqing. COA of Formula: C20H14O The article mentions the following:

Indocyanine green (ICG), a safe and clin. approved near-IR (NIR) dye, was recently explored as a potential photosensitizer due to its excellent photophys. properties. However, ICG tends to form aggregations in physiol. solution, causing fluorescence quenching, fast blood clearance and thereby inefficient tumor accumulation. Herein, we report ICG-based nanodrug delivery systems formed by self-assembly of ICG and chemotherapeutic drugs without any excipients for combined chemo- and photo-therapy. Taking advantage of the amphiphilic aromatic structure, ICG readily bounded with hydrophobic aromatic drugs such as SN38 and formed well-dispersible nanoparticles, which reduced its aggregation-induced quenching and thus greatly improved its photodynamic efficiency. The loaded hydrophobic drugs elicited chemotherapy synergizing the photodynamic therapy, giving rise to much enhanced antitumor activity in vitro and in vivo against human glioblastoma cells and breast cancer cells upon NIR irradiation The work demonstrates the fabrication of readily translational nanoformulations of hydrophobic drugs using amphiphilic drugs. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6COA of Formula: C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.COA of Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 2022,Geng, Xiaorui; Chen, Yuhao; Chen, Zhiyi; Wei, Xianyuan; Dai, Yunlu; Yuan, Zhen published an article in Ultrasonics Sonochemistry. The title of the article was 《Oxygen-carrying biomimetic nanoplatform for sonodynamic killing of bacteria and treatment of infection diseases》.Recommanded Product: 5471-63-6 The author mentioned the following in the article:

Among various novel antimicrobial therapies, sonodynamic therapy (SDT) exhibits its advantages for the treatment of bacterial infections due to its high penetration depth and low side effects. In this study, a new nanosonosensitizer (HFH@ZIF-8) that loads sonosensitizer hematoporphyrin monomethyl ether (HMME) into zeolitic imidazolate framework-8 (ZIF-8), was constructed for killing multidrug-resistant (MDR) bacteria and treatment of in vivo infection diseases by SDT. In particular, the developed HFH@ZIF-8 exhibited enhanced water-solubility, good biocompatibility, and improved disease-targeting capability for delivering and releasing HMME and ablating the infected lesion. More importantly, the presence of oxygen-carrying Hb for HFH@ZIF-8 can offer sufficient oxygen consumption by SDT, augmenting the efficacy of SDT by improving ROS generating efficiency against deep tissue multidrug-resistant bacterial infection. Therefore, this study paves a new avenue for treating infection disease, particularly for antibiotic resistant bacterial infection. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Recommanded Product: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ercin, Ugur; Aribas, Yavuz Kemal; Tefon Aribas, Atike Burcin; Bilgihan, Ayse; Bilgihan, Kamil published their research in Eye (London, United Kingdom) in 2021. The article was titled 《Singlet oxygen formation during accelerated and hyperaccelerated corneal crosslinking: in vitro study》.HPLC of Formula: 5471-63-6 The article contains the following contents:

To evaluate the singlet oxygen (1O2) production of oxygen assisted %0.1 riboflavin and UV-A (UVA) crosslinking therapy (with and without oxygen assistance), in combination with standard, accelerated and hyper-accelerated procedures via an important quantitive marker of 1O2 which is the photo-oxidation of 1,3 diphenylisobenzofuran (DPBF). %0.1 Riboflavin-containing wells were irradiated with UVA light (365-nm wavelength) with or without 2-4-6-8 L/min oxygen flow assistance. Measurements of decrease in absorbance of DPBF were made in 30 mW (hyper-accelerated), 9 mW (accelerated), and 3 mW UV-A (standard) applications, and with addnl. 2-4-6-8 L/min oxygen flow in 30 mW and 2 L/min oxygen flow in 9 mW. A total of 8 different UV-A irradiance with and without oxygen supplementation groups were formed. 2 L/min Oxygen assisted accelerated UV-A irradiance group has shown a greater decrease in DPBF absorbance compared to Dresden protocol. (p = 0.014) Also, Dresden protocol has shown a greater decrease in DPBF compared to all groups except accelerated crosslinking with 2 L/min oxygen. (p < 0.001) Oxygen assisted hyper-accelerated crosslinking groups were showed greater reduction in DPBF absorbance compared to standard crosslinking without oxygen groups. (p < 0.001). Oxygen supplementation may increase the singlet oxygen generation to the similar levels of Dresden Protocol's in accelerated group. Also, more singlet oxygen generation with oxygen supplementation compared to standard UV-A application might be considered to be promising in terms of shortening the crosslinking therapy. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6HPLC of Formula: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.HPLC of Formula: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yang, Liqun; Wang, Jingyang; Wang, Yue; Li, Xiaotong; Liu, Wei; Zhang, Zhaoguo; Xie, Xiaomin published an article in 2021. The article was titled 《Stereoselective Synthesis of cis-2-Ene-1,4-diones via Aerobic Oxidation of Substituted Furans Catalyzed by ABNO/HNO3》, and you may find the article in Journal of Organic Chemistry.Synthetic Route of C20H14O The information in the text is summarized as follows:

A highly efficient and selective catalytic system, ABNO (9-azabicyclo-[3.3.1]nonane N-oxyl)/HNO3, for the aerobic oxidation of substituted furans to cis-2-ene-1,4-diones under mild reaction conditions using oxygen as the oxidant was reported. The catalyst system was amenable to various substituted (mono-, di-, and tri-) furans and tolerates diverse functional groups, including cyano, nitro, naphthyl, ketone, ester, heterocycle, and even formyl groups. Based on the control and 18O-labeling experiments, the possible mechanism of the oxidation was proposed. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Synthetic Route of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Synthetic Route of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reference of 1,3-DiphenylisobenzofuranIn 2020 ,《Electrochemically deposited poly(selenophene)-fullerene photoactive layer: Tuning of the spectroscopic properties towards visible light-driven generation of singlet oxygen》 appeared in Applied Surface Science. The author of the article were Nyga, Aleksandra; Motyka, Radoslaw; Bussetti, Gianlorenzo; Calloni, Alberto; Sangarashettyhalli Jagadeesh, Madan; Fijak, Sylwia; Pluczyk-Malek, Sandra; Data, Przemyslaw; Blacha-Grzechnik, Agata. The article conveys some information:

A selenophene-containing fullerene dyad (C60Se) was electrochem. co-deposited with bis-selenophene (BisSe) to form a visible light absorbing poly(selenophene) layer with incorporated fullerene photosensitizers on platinum (Pt) or indium-tin oxide (ITO) substrates. The resulting photoactive films (P(C60Se_BisSe)) were characterized by cyclic voltammetry, UV-Vis, IR, Raman and X-ray photoelectron spectroscopies. The efficiency of P(C60Se_BisSe) towards singlet oxygen photogeneration was investigated by applying reactions with chem. traps, i.e. α-terpinene and 1,3-diphenylisobenzofuran (DPBF), monitored by UV-Vis spectroscopy. The composition of the electropolymerized layer was controlled by varying the monomers ratio in the feed solution and it had a strong influence on the spectroscopic and photosensitizing properties of the deposited film. It has been shown that the efficiency of the visible light-driven singlet oxygen generation can be increased by optimizing the ratio between C60 photosensitizers and organic units in the layer. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Reference of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Reference of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Soucy, C.; Favreau, D.; Kayser, M. M. published an article on January 9 ,1987. The article was titled 《The regioselectivity of metal hydride reductions of 3-substituted phthalic anhydrides》, and you may find the article in Journal of Organic Chemistry.Recommanded Product: 105694-46-0 The information in the text is summarized as follows:

The reduction of 3-methoxyphthalide by metal hydrides was reinvestigated. Various effects controlling selectivity of reductions in 3-substituted phthalides were studied, and a qual. interpretation of the results was proposed. Methods for obtaining enhanced yields of one or the other lactonic product were developed. In addition to this study using 7-Iodoisobenzofuran-1(3H)-one, there are many other studies that have used 7-Iodoisobenzofuran-1(3H)-one(cas: 105694-46-0Recommanded Product: 105694-46-0) was used in this study.

7-Iodoisobenzofuran-1(3H)-one(cas: 105694-46-0) belongs to benzofurans.Recommanded Product: 105694-46-0Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《External-photocatalyst-free visible-light-mediated aerobic oxidation and 1,4-bisfunctionalization of N-alkyl isoquinolinium salts》 was written by Zhou, Youkang; Liu, Wei; Xing, Zhiming; Guan, Jiali; Song, Zhibin; Peng, Yiyuan. Application In Synthesis of 1,3-Diphenylisobenzofuran And the article was included in Organic Chemistry Frontiers in 2020. The article conveys some information:

Visible-light-mediated aerobic alternate transformations of N-alkyl isoquinolinium salts I [X = I, Br, BF4; R = H, OMe, Ph, Cl, Br; R1 = H, Br, Ph, I; R2 = H, Et, naphthalen-1-yl, 2-bromophenyl, etc.] and 2,2′-(butane-1,4-diyl)bis(isoquinolin-2-ium) iodide/quinolinium salts II [R3 = H, Br, Ph, naphthalen-1-yl; R4 = H, naphthalen-1-yl, 3-methylphenyl, 2-phenylethyl; R5 = H, Ph, Br, OMe, Cl] in the absence of any extra added photocatalyst are reported. Here, a highly concise, sustainable and low-cost protocol to produce unsaturated lactams III/IV and 2,2′-(butane-1,4-diyl)bis(isoquinolin-1(2H)-one) from oxidation of their corresponding isoquinolinium salts I or quinolinium salts II using air as an oxidant was developed. Important building blocks for further modification of biol. active isoquinolones, 4-iodoisoquinolinones III and 2,2′-(butane-1,4-diyl)bis(4-iodoisoquinolin-1(2H)-one) were also produced through 1,4-bisfunctionalization of isoquinolinium salts I without the use of any transition metal. Gram-scale synthesis was achieved under sunlight with exposure to the open air. Mechanism studies suggested that singlet oxygen generation triggered by isoquinolinium salts I/quinolinium salts II under visible light irradiation and trace water may lead to multiple pathways for the aerobic transformations of N-alkyl iminium salts. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Application In Synthesis of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Sun, Jifu; Dai, Ying; Hou, Yuqi; Wu, Qianwen; Ma, Linzheng; Zhao, Jianzhang; Wang, Bo published their research in Journal of Physical Chemistry A in 2021. The article was titled 《Weakened Triplet-Triplet Annihilation of Diiodo-BODIPY Moieties without Influence on Their Intrinsic Triplet Lifetimes in Diiodo-BODIPY-Functionalized Pillar[5]arenes》.HPLC of Formula: 5471-63-6 The article contains the following contents:

The triplet-triplet annihilation (TTA) effect of sensitizers themselves can lead to the addnl. quenching of lifetimes of triplet states; therefore, how to weaken the TTA effect of sensitizers is an urgent issue to be resolved for their further applications. Besides, it remains a tremendous challenge for constructing supramol. systems of photosensitizers based on photosensitizer-functionalized pillararenes because there have been very few investigations on them. Thus, 2,6-diiodo-1,3,5,7-tetramethyl-8-phenyl-4,4-difluoroboradiazaindacene (DIBDP) and ethoxy pillar[5]arene (EtP5) were utilized to synthesize a DIBDP-functionalized pillar[5]arene (EtP5-DIBDP), a cyano-containing DIBDP (G) used as a guest mol. was also prepared, and they were used to investigate the electron-transfer mechanism between EtP5 and DIBDP moieties and weaken the TTA effect of DIBDP moieties. The theor. computational results of frontier MOs and isosurfaces of spin d. preliminarily predicted that the cavities of the EtP5 moiety had influence on the fluorescence emission of DIBDP units but not on their triplet states in EtP5-DIBDP. The fluorescence emission intensities in a variety of solvents with different polarities and electrochem. studies revealed that there was electron transfer from EtP5 to the DIBDP units, and the electron-transfer process had influence on the fluorescence emission but not on the triplet states of DIBDP moieties in EtP5-DIBDP, which verified the results of d. functional theory calculations The triplet state lifetimes of EtP5-DIBDP were longer than those of DIBDP and G and the photooxidation abilities of EtP5-DIBDP were better than those of DIBDP and G at a high concentration (1.0 x 10-5 M) in various solvents; in contrast, the intrinsic triplet state lifetimes and singlet oxygen quantum yields (ΦΔ) of DIBDP, G, and EtP5-DIBDP were very similar. This was because the steric hindrance of EtP5 moieties could weaken the TTA effect of DIBDP moieties without influencing their intrinsic triplet state lifetimes in EtP5-DIBDP. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6HPLC of Formula: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.HPLC of Formula: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem