Day: October 20, 2022

HPLC of Formula: 5471-63-6In 2022 ,《Photophysical behaviors of a shape-persistent zinc porphyrin organic cage》 appeared in New Journal of Chemistry. The author of the article were Yang, Wei; Wang, Chen; Liu, Kunhui; Liu, Chao; Jiang, Jianzhuang. The article conveys some information:

A pair of chiral metallic porphyrin cages, (R)/(S)-PTC-1(Zn), were afforded by pure chiral cyclohexanediamine reacting with the zinc 5,15-di[3′,5′-diformyl-(1,1′-biphenyl)]porphyrin. Both their chiral tubular structures were demonstrated via single crystal diffraction and CD studies. In addition, the photophys. behavior of the metallic organic cage, in combination with the monomeric reference zinc 5,15-di[3′,5′-cyclohexyliminomethyl-1,1′-biphenyl]porphyrin (ZnCBPP), was systematically explored by using UV-visible, fluorescence and transient absorption (TA) spectroscopy in solution TA data disclose that PTC-1(Zn) possesses a much longer triplet lifetime than monomer ZnCBPP. In addition, the homogeneous system of the cage enables the production of more singlet oxygen than the monomeric compound according to 1,3-diphenylisobenzofuran photodegradation, ESR spectroscopy and aerobic oxidation of benzylamine under visible light irradiation The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6HPLC of Formula: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.HPLC of Formula: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant》 was written by Zhang, Xiangyu; Zhang, Guannan; Chai, Maozhou; Yao, Xiaohong; Chen, Weiyi; Chu, Paul K.. Related Products of 5471-63-6This research focused ontitanium dioxide nanorod array antibacterial activity biofilm eradication implant; Anti-biofilm; Light-triggered therapy; Physical insertion; TiO2 nanorod; Titanium implants. The article conveys some information:

Treatment of implant-associated infection is becoming more challenging, especially when bacterial biofilms form on the surface of the implants. Developing multi-mechanism antibacterial methods to combat bacterial biofilm infections by the synergistic effects are superior to those based on single modality due to avoiding the adverse effects arising from the latter. In this work, TiO2 nanorod arrays in combination with irradiation with 808 near-IR (NIR) light are proven to eradicate single specie biofilms by combining photothermal therapy, photodynamic therapy, and phys. killing of bacteria. The TiO2 nanorod arrays possess efficient photothermal conversion ability and produce a small amount of reactive oxygen species (ROS). Physiol., the combined actions of hyperthermia, ROS, and puncturing by nanorods give rise to excellent antibacterial properties on titanium requiring irradiation for only 15 min as demonstrated by our experiments conducted in vitro and in vivo. More importantly, bone biofilm infection is successfully treated efficiently by the synergistic antibacterial effects and at the same time, the TiO2 nanorod arrays improve the new bone formation around implants. In this protocol, besides the biocompatible TiO2 nanorod arrays, an extra photosensitizer is not needed and no other ions would be released. Our findings reveal a rapid bacteria-killing method based on the multiple synergetic antibacterial modalities with high biosafety that can be implemented in vivo and obviate the need for a second operation. The concept and antibacterial system described here have large clin. potential in orthopedic and dental applications. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Related Products of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Related Products of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Ground- and Excited-State Properties of Iron(II) Complexes Linked to Organic Chromophores》 was written by Dierks, Philipp; Paepcke, Ayla; Bokareva, Olga S.; Altenburger, Bjoern; Reuter, Thomas; Heinze, Katja; Kuehn, Oliver; Lochbrunner, Stefan; Bauer, Matthias. HPLC of Formula: 5471-63-6 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

Two new bichromophoric complexes, [Fe(bim-ant)2]2+ and [Fe(bim-pyr)2]2+ ([H2-bim]2+ = 1,1′-(pyridine-2,6-diyl)bis(3-methyl-1H-imidazol-3-ium); ant = 9-anthracenyl; pyr = 1-pyrenyl), are investigated to explore the possibility of tuning the excited-state behavior in photoactive iron(II) complexes to design substitutes for noble-metal compounds The ground-state properties of both complexes are characterized thoroughly by electrochem. methods and optical absorption spectroscopy, complemented by time-dependent d. functional theory calculations The excited states are investigated by static and time-resolved luminescence and femtosecond transient absorption spectroscopy. Both complexes exhibit room temperature luminescence, which originates from singlet states dominated by the chromophore (1Chrom). In the cationic pro-ligands and in the iron(II) complexes, the emission is shifted to red by up to 110 nm (5780 cm-1). This offers the possibility of tuning the organic chromophore emission by metal-ion coordination. The fluorescence lifetimes of the complexes are in the nanosecond range, while triplet metal-to-ligand charge-transfer (3MLCT) lifetimes are around 14 ps. An antenna effect as in ruthenium(II) polypyridine complexes connected to an organic chromophore is found in the form of an internal conversion within 3.4 ns from the 1Chrom to the 1MLCT states. Because no singlet oxygen forms from triplet oxygen in the presence of the iron(II) complexes and light, efficient intersystem crossing to the triplet state of the organic chromophore (3Chrom) is not promoted in the iron(II) complexes. Two new multichromophoric iron(II) pyridyl N-heterocyclic carbene complexes functionalized with anthracene and pyrene in its backbones are presented. Ground- and excited-state characterization in combination with time-dependent d. functional theory shows that the triplet metal-to-ligand charge-transfer lifetime is prolonged efficiently, and an antenna effect is observed from the excited chromophore to the singlet metal-to-ligand charge-transfer state. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6HPLC of Formula: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.HPLC of Formula: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cheng, Jianjun; Wang, Shu; Zhao, Haitian; Liu, Yan; Yang, Xin published an article in 2021. The article was titled 《Exploring the self-assembly mechanism and effective synergistic antitumor chemophototherapy of a biodegradable and glutathione responsive ursolic acid prodrug mediated photosensitive nanodrug》, and you may find the article in Biomaterials Science.Application In Synthesis of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Supermolecularly assembled photochemotherapeutic nanocomposites composed of pure drug small mols. are promising for synergistically improved tumor therapy, yet potential multiple challenges remain to be addressed. Herein, we rationally designed a novel multifunctional small mol. disulfide modified natural pentacyclic triterpene of ursolic acid (UASS) that simultaneously possesses self-assembly ability, glutathione (GSH) responsivity, anticancer activity, biocompatibility and biodegradability and further constructed carrier-free GSH-sensitive photosensitive nanocomposite UASS-Ce6 NPs for safe and synergistically improved chemophototherapy. Specifically, UASS-Ce6 NPs exhibit improved 1 O2 generation by reducing the energy gap (ΔEST) of Ce6 as determined by d. functional theory. Meanwhile, mol. dynamics simulation revealed the possible reasons why free UASS self-assembles and UASS-Ce6 NPs with different assembled morphologies may be primarily attributed to the coplanar arrangement of UASS dimer units. Importantly, via noncovalent π-stacking and hydrophobic interactions, the resulting co-assemblies showed improved water solubility, increased intercellular ROS generation, desirable GSH sensibility, excellent biocompatibility, and enhanced tumor accumulation accompanied by rapid biodegradation, thus leading to significant in vitro and in vivo synergistic antitumor efficacy with favorable biosafety. This study provides a promising insight into the development of a self-assembled active single component platform with desirable stimuli responsiveness and biosafety toward synergistic antitumor therapy based on terpenoid natural small mols. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Application In Synthesis of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 2022,Wang, Zirui; Song, Qiusheng; Zhu, Lin; Zhao, Chengyan; Ma, Haihong published an article in Journal of Fluorescence. The title of the article was 《Synthesis, Characterization of NR@SiO2/PNIPAm-co-Ppa Composite Nanogel and Study On Its Application in Photodynamic Therapy》.Electric Literature of C20H14O The author mentioned the following in the article:

In the present study, a novel composite nanogel based on fluorescence resonance energy transfer (FRET) and its application for photodynamic therapy is reported. First of all, nanoparticles of silica doped with Nile Red (NR) were prepared by Stober method, then they were decorated by γ-methacryloxypropyltrimethoxysilane (MPS) to prepare MPS decorated NR@SiO2 nanoparticles, and finally they were copolymerized with N-isopropylacrylamide (NIPAm) and Pyropheophorbide-a (Ppa) by free radical copolymerization, and composite nanogel of NR@SiO2/PNIPAm-co-Ppa was fabricated. The microstructure of the as-prepared nanogel was characterized by Fourier transform IR spectrum (FTIR), photoluminescence (PL), UV-Visible spectrophotometer (UV-Vis), dynamic light scattering (DLS) and transmission electron microscopy (TEM). PL spectrum indicated that, under irradiation of visible light source, energy can be transferred from NR to Ppa. UV-Vis spectrum demonstrated that aggregation of Ppa is prevented efficiently and Ppa exists as “”monomer”” state in the composite nanogel. Under irradiation of laser, singlet oxygen (1O2) can be produced efficiently by excited nanogel. The in vitro cytotoxicity test showed that HeLa cells can be killed by the composite nanogel. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Electric Literature of C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Electric Literature of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Safety of 1,3-DiphenylisobenzofuranIn 2022 ,《Singlet oxygen formation from photoexcited P3HT:PCBM films applied in oxidation reactions》 appeared in Materials Advances. The author of the article were Nyga, Aleksandra; Blacha-Grzechnik, Agata; Podsiadly, Przemyslaw; Duda, Alicja; Kepska, Kinga; Krzywiecki, Maciej; Motyka, Radoslaw; Janssen, Rene A. J.; Data, Przemyslaw. The article conveys some information:

Poly(3-hexylthiophene) thin films containing carbon-based nanostructures, i.e. fullerenes such as buckminsterfullerene (C60) or phenyl-C61-butyric acid Me ester (PCBM), or single-walled carbon nanotubes, were investigated as heterogeneous photosensitizers producing singlet oxygen (1O2) in aerated organic solvents. Thin films were deposited on borosilicate glass using spin coating and characterized by profilometry, UV-vis, Raman and XPS. Photogeneration of 1O2 was confirmed by photooxidation of 1,3-diphenylisobenzofuran and by reaction of 1,5-dihydroxynaphthalene to juglone. The photochem. efficiency of the blends was found to depend on the carbon-based photosensitizer and can be increased by varying its concentration in the poly(3-hexylthiophene) matrix. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Safety of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Safety of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application of 5471-63-6In 2022 ,《Preparation of a porphyrin-polyoxometalate hybrid and its photocatalytic degradation performance for mustard gas simulant 2-chloroethyl ethyl sulfide》 appeared in Chinese Chemical Letters. The author of the article were Yang, Ying; Tao, Fangsheng; Zhang, Lijuan; Zhou, Yunshan; Zhong, Yuxu; Tian, Shubo; Wang, Yong′an. The article conveys some information:

By combining 5,10,15,20-tetra(4-chlorine)phenylporphyrin (TClPP) and α-Keggin polyoxometalate H5PV2Mo10O40 (H5PVMo) via a simple ion-exchange method, an organic-inorganic hybrid material [C44H28N4Cl4]1.5[H2PMo10V2O40]·2C2H6O (H2TClPP-H2PVMo) was prepared and thoroughly characterized by a variety of techniques. The homogeneous photocatalytic degradation of 2-chloroethyl Et sulfide (CEES) (5 μL) by H2TClPP-H2PVMo (1 x 10-6 mol/L) was studied in methanol and methanol-water mixed solvent (volume/volume = 1:1), in which the degradation rate of CEES reached 99.52% and 99.14%, resp. The reaction followed first-order reaction kinetics, and the half-life and kinetic constant in methanol and the mixed solvent were resp. 33.0 min, -0.021 min-1 and 15.7 min, -0.043 min-1. Mechanism anal. indicated that under visible light irradiation in the air, CEES was degraded via oxidation and alcoholysis/hydrolysis in methanol and the mixed solvent. O2·- and 1O2 generated by H2TClPP-H2PVMo selectively oxidized CEES into a nontoxic sulfoxide. Singlet oxygen capture experiments showed that H2TClPP-H2PVMo (θ= 0.73) had a higher quantum yield of singlet oxygen than TClPP (θ= 0.35) under an air atm. and visible light irradiation In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Application of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

SDS of cas: 5471-63-6In 2020 ,《A strategy for monitoring oxygen concentration, oxygen consumption, and generation of singlet oxygen using a phosphorescent photosensitizer》 was published in Journal of Luminescence. The article was written by Zang, Lixin; Zhao, Huimin. The article contains the following contents:

Monitoring oxygen concentration ([O2]), oxygen consumption, and generation of singlet oxygen (1O2) is critical in photodynamic therapy (PDT) used for the precise treatment of cancer. To this end, a strategy based on a phosphorescent photosensitizer, gadolinium-hematoporphyrin monomethyl ether (Gd-HMME), was developed for monitoring [O2] in this study. Diphenylisobenzofuran (DPBF) was used to consume 1O2 produced by the Gd-HMME-mediated PDT. A sealed system comprising Gd-HMME and DPBF under irradiation was designed to simulate PDT when tissue oxygen was insufficient. Upon irradiation by a 532-nm laser, Gd-HMME phosphorescence initially increased rapidly, reached a maximum, and remained unchanged thereafter, because oxygen in the system was exhausted. The increase in phosphorescence increased with increasing fluence rates, suggesting that the change in phosphorescence was related to oxygen consumption. The depletion of DPBF in the system indicated the generation of 1O2 and a reaction between DPBF and 1O2. The phosphorescence decreased rapidly when the system was re-exposed to air. In contrast, the change in the phosphorescence intensity in an open cuvette was minimal and could be neglected. Thus, [O2] and generation of 1O2 in PDT could be monitored using the phosphorescence intensity of the photosensitizer, based on the dependence of phosphorescence and singlet oxygen quantum yield on [O2]. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Godoy, Agustin A.; Bernini, Maria C.; Funes, Matias D.; Sortino, Maximiliano; Collins, Sebastian E.; Narda, Griselda E. published their research in Dalton Transactions in 2021. The article was titled 《ROS-generating rare-earth coordination networks for photodynamic inactivation of Candida albicans》.SDS of cas: 5471-63-6 The article contains the following contents:

Water-ethanol suspensions of 2D coordination network (CN) based on rare earth elements and mixed ligands were evaluated as reactive oxygen species (ROS) generators under UV light irradiation, in contact with a biomimetic substrate (tryptophan) or an O2(1Δg) quencher (1,3-diphenylisobenzofuran; 1,3-DPBF). A combination of bottom-up and top-down strategies was implemented in order to obtain nano-sized CN particles and the subsequent colloidal suspensions were also tested towards photodynamic inactivation of Candida albicans (C. albicans). SEM, TEM, FTIR, and XRD techniques were applied to characterize the solids and ICP-AES was employed to determine the metal content of the colloidal suspensions. Promising results were found indicating that the presence of Tb3+ allows an intersystem crossing suitable for singlet oxygen generation, resulting in the antifungal activity of C. albicans culture upon UV-irradiation1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Nanostructured lipid carrier delivering chlorins e6 as in situ dendritic cell vaccine for immunotherapy of gastric cancer》 was published in Journal of Materials Research in 2020. These research results belong to Mao, Mao; Liu, Senfeng; Zhou, Yiming; Wang, Gonghe; Deng, Jianping; Tian, Lei. Category: benzofurans The article mentions the following:

The recent scientific progress has shown the promising effect of the vaccine in immunotherapy of cancer, which relies on the antigen processing/presentation capability of dendritic cells (DCs). As a result, cancer vaccines targeting DC, which also named as DC vaccine, was a hot-spot in vaccine development. Herein, a nanostructured lipid carrier (NLC) was employed to load chlorin e6 (Ce6) to serve as a potential in situ DC vaccine (NLC/Ce6) for effective immunotherapy of gastric cancer. Taking advantage of the photodynamic effect of Ce6 to generate reactive oxygen species (ROS) under laser irradiation, the NLC/Ce6 was able to trigger cell death and expose tumor-associated antigen (TAA). Moreover, mimicking the natural inflammatory response, the ROS can also recruit the DC for the effective processing/presentation of the in situ exposed TAA. As expected, we observed strong capability DC vaccination efficacy of this platform to effectively inhibit the growth of both primary and distant gastric tumors. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Category: benzofurans)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem