Day: October 20, 2022

Wang, Qi; Cai, Jie; Niu, Xinrui; Wang, Jing; Liu, Jiawei; Xie, Chen; Huang, Wei; Fan, Quli published an article in 2021. The article was titled 《Rational design of high performance nanotheranostics for NIR-II fluorescence/magnetic resonance imaging guided enhanced phototherapy》, and you may find the article in Biomaterials Science.Recommanded Product: 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Nanotheranostics, which can provide great insight into cancer therapy, has been deemed as a promising technol. to settle the unmet medical needs. The rational design of high performance nanotheranostics with multiple complementary imaging features and satisfactory therapeutic efficacy is particularly valuable. Herein, versatile nanotheranostic agents DPPB-Gd-I NPs were fabricated by using gadolinium-diethylenetriaminepentaacetic acid chelates and an iodine-decorated copolymer as encapsulation matrixes to encapsulate a polymer DPPB through one-step nanopptn. We have demonstrated that such nanoagents are able to efficiently damage tumors under single dose injection and NIR laser illumination conditions due to the enhanced photodynamic therapy and enhanced photothermal therapy (the tumor inhibition rate was as high as 94.5%). Moreover, these nanoagents can be utilized as dual-modal NIR-II fluorescence/magnetic resonance imaging probes for tumor diagnosis with high sensitivity, deep tissue penetration, and excellent spatial resolution Overall, this work offers a powerful tactic to fabricate high performance nanotheranostics for clin. application.1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 1,3-Diphenylisobenzofuran) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Recommanded Product: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Kong, Na; Zhang, Hanjie; Feng, Chan; Liu, Chuang; Xiao, Yufen; Zhang, Xingcai; Mei, Lin; Kim, Jong Seung; Tao, Wei; Ji, Xiaoyuan published their research in Nature Communications in 2021. The article was titled 《Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy》.Category: benzofurans The article contains the following contents:

The modulation of intracellular reactive oxygen species (ROS) levels is crucial for cellular homeostasis and determination of cellular fate. A sublethal level of ROS sustains cell proliferation, differentiation and promotes tumor metastasis, while a drastic ROS burst directly induces apoptosis. Herein, surface-oxidized arsenene nanosheets (As/AsxOy NSs) with type II heterojunction are fabricated with efficient ·O2- and 1O2 production and glutathione consumption through prolonging the lifetime of photo-excited electron-hole pairs. Moreover, the portion of AsxOy with oxygen vacancies not only catalyzes a Fenton-like reaction, generating ·OH and O2 from H2O2, but also inactivates main anti-oxidants to cut off the ′′retreat routes′′ of ROS. After polydopamine (PDA) and cancer cell membrane (M) coating, the engineered As/AsxOy@PDA@M NSs serve as an intelligent theranostic platform with active tumor targeting and long-term blood circulation. Given its narrow-band-gap-enabled in vivo fluorescence imaging properties, As/AsxOy@PDA@M NSs could be applied as an imaging-guided non-invasive and real-time nanomedicine for cancer therapy. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Category: benzofurans)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Hollow ferric-tannic acid nanocapsules with sustained O2 and ROS induction for synergistic tumor therapy》 was written by Zhu, Huimin; Cao, Guodong; Qiang, Chu; Fu, YiKe; Wu, Yulian; Li, Xiang; Han, Gaorong. Product Details of 5471-63-6 And the article was included in Biomaterials Science in 2020. The article conveys some information:

Nanoparticles presenting promoted catalytic activity, oxygen induction and loading capability are in high demand for effective synergistic tumor therapy. Herein, ferric-tannic acid complex nanocapsules with fine hollow microstructure (HFe-TA) are synthesized and loaded with a photosensitizer (indocyanine green, ICG) for synergistic tumor therapy. In acidic environment, ICG@HFe-TA decomposes and releases Fe3+ ions, TA and ICG mols. Fe3+, with low catalytic activity, is effectively converted into highly catalytic Fe2+ by the reductant TA, enabling promoted efficacy of .OH induction. More importantly, the ROS (1O2) induction by ICG is significantly enhanced under 808 nm laser irradiation due to the O2 byproduct of Fe3+/Fe2+ conversion. In consequence, the ICG@HFe-TA nanoparticles exhibit considerable in vitro and in vivo tumor inhibition owing to the combined effect of .OH and 1O2 induced intracellularly. This study has therefore demonstrated a potential platform enabling combined photodynamic and chemodynamic therapy with high efficacy. The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Product Details of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Product Details of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zeki, K.; Lokmaci, E.; Dogu, Ezgi; Khene, S.; Salih, B.; Canlica, M. published an article in 2021. The article was titled 《Photophysicochemical properties of [Tetrakis 6-(tert-butyl-2,3-dihydrobenzo [b] [1,4] dioxine) phthalocyaninato] In(III) and Zn(II) with very high singlet oxygen quantum yield》, and you may find the article in Inorganica Chimica Acta.Application of 5471-63-6 The information in the text is summarized as follows:

Synthesis and photophysicochem. properties of [tetrakis 6-(tert-butyl-2,3-dihydrobenzo [b] [1,4] dioxine) phthalocyaninato] In(III) (InPc-4) and [tetrakis 6-(tert-butyl-2,3-dihydrobenzo [b] [1,4] dioxine) phthalocyaninato] Zn(II) (ZnPc-5) containing 4-tert-butylcatechol at the peripheral positions are synthesized for application as photosensitizers in photodynamic therapy (PDT). Fluorescence quantum yield, singlet oxygen quantum yield and photodegradation quantum yield were determined for each complex. High singlet oxygen quantum yield of 0.84 and 0.86 (in THF) were obtained for InPc-4 and ZnPc-5, resp. D. functional theory (DFT) and time dependent d. functional theory (TDDFT) were carried out to rationalise the exptl. results. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Application of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Formula: C20H14OIn 2022 ,《Persistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy》 was published in Bioactive Materials. The article was written by Chang, Meiqi; Feng, Wei; Ding, Li; Zhang, Hongguang; Dong, Caihong; Chen, Yu; Shi, Jianlin. The article contains the following contents:

Tumor oxygenation level has been regarded as an attractive target to elevate the efficiency of photodynamic therapy (PDT). Cyanobacterial photosynthesis-mediated reversal of tumor hypoxia could enable an oxygen-boosted PDT, but is limited by scant penetration depth and efficiency of external light. Herein, aiming at the dual purposes of reducing biol. toxicity induced by long-term light irradiation and alleviating hypoxia, we here introduce a novel-designed CaAl2O4:Eu,Nd blue persistent luminescence material (PLM) as the in vivo light source after pre-excited in vitro. The ingenious construction of blue-emitting PLM with “”optical battery”” characteristics activates cyanobacterial cells and verteporfin simultaneously, which performs the successive oxygen supply and singlet oxygen generation without the long-term external excitation, resulting in the modulated tumor hypoxic microenvironment and enhanced photodynamic tumor proliferation inhibition efficiency. Both in vitro cellular assessment and in vivo tumor evaluation results affirm the advantages of self-produced oxygen PDT system and evidence the notable antineoplastic outcome. This work develops an irradiation-free photosynthetic bacteria-based PDT platform for the optimization of both oxygen production capacity and light utilization efficiency in cancer treatment, which is expected to promote the clin. progress of microbial-based photonic therapy. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Excellent capacity of singlet oxygen generation by gadolinium labelled sinoporphyrin sodium》 was written by Liu, Ting; Zhang, Honglin; Zhao, Hua; Zhang, Zhiguo; Tian, Ye. Computed Properties of C20H14O And the article was included in Journal of Luminescence in 2020. The article conveys some information:

In this paper, we studied the effect of imidazole, a small organic mol. used as a solvent in the synthesis of multifunctional photosensitizers (PSs), on the singlet oxygen quantum yield (ΦΔ) of the PS, gadolinium-containing sinoporphyrin sodium (Gd-DVDMS), using a relative method with Rose Bengal as the reference and 1,3-diphenylisobenzofuran as the singlet oxygen trapping reagent. After completely removal of imidazole by dialysis, the ΦΔ value of Gd-DVDMS was obtained to be as high as 0.97. In addition, with an increase in the imidazole concentration, the ΦΔ of Gd-DVDMS gradually decreased, and stabilized at a value of 0.37. To understand the above phenomenon, the UV-visible absorption and photoluminescence spectra of Gd-DVDMS for different imidazole concentrations were analyzed. The triplet state quantum yield of Gd-DVDMS was constant, while the O2 quenching rate of the triplet state decreased; this indicated that the energy exchange between the PS and O2 was reduced by imidazole. We deduced that decrease in ΦΔ was attributable to the increase in the distance between Gd-DVDMS and O2, owing to imidazole wrapping around Gd-DVDMS. It is speculated that as the wrapping progressed, the effects of the dissolution and attachment of imidazole reached a balance, and hence, the ΦΔ remained constant The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Computed Properties of C20H14OIn 2021 ,《Self-Assembled Platinum Supramolecular Metallacycles Based on a Novel TADF Photosensitizer for Efficient Cancer Photochemotherapy》 was published in Molecular Pharmaceutics. The article was written by Lv, Shibo; Miao, Yuyang; Zheng, Daoyuan; Li, Xiaoju; Liu, Dapeng; Song, Fengling. The article contains the following contents:

Recently, supramol. coordination complexes (SCCs) based on photosensitizers as bridging ligands have attracted great attention in cancer therapy owing to their synergistic effect between photodynamic therapy (PDT) and chemotherapy. Herein, a highly emissive supramol. platinum triangle BTZPy-Pt based on a novel type of photosensitizer BTZPy with thermally activated delayed fluorescence (TADF) was fabricated. The BTZPy and BTZPy-Pt exhibited strong luminescence emission in the visible range with high quantum yields (quantum yields (QYs) for BTZPy and BTZPy-Pt were about 78 and 62% in ethanol solutions, resp.). Addnl., BTZPy had been proved to be an excellent photosensitizer with superior 1O2 generation capability (the 1O2 generation quantum yield reached up to ca. 95%) for PDT. By the combination of the excellent phototoxicity of BTZPy and the antitumor activity of the Pt center, the platinum triangle BTZPy-Pt demonstrated a highly efficient anticancer performance toward HeLa cells (IC50: 0.5μg mL-1). This study not only provides a blueprint to fabricate new types of photosensitizers but also paves a way to design novel SCCs for efficient PDT. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Impact of photosensitizer orientation on the distance dependent photocatalytic activity in zinc phthalocyanine-nanoporous gold hybrid systems》 was written by Steinebrunner, David; Schnurpfeil, Guenter; Kohroede, Mathis; Epp, Alexander; Klangnog, Khaetthariya; Tapia Burgos, Jorge Adrian; Wichmann, Andre; Woehrle, Dieter; Wittstock, Arne. Formula: C20H14OThis research focused onzinc phthalocyanine gold self assembly diphenylisobenzofuran photocatalytic oxidation. The article conveys some information:

Nanoporous gold powder was functionalized in a two-step approach by an azide terminated alkanethiol self-assembled monolayer (SAM) and a zinc(II) phthalocyanine (ZnPc) derivative by copper catalyzed azide-alkyne cycloaddition (CuAAC). A series of different hybrid systems with systematic variation of the alkyl chain length on both positions, the alkanethiol SAM and the peripheral substituents of the ZnPc derivative, was prepared and studied in the photooxidation of diphenylisobenzofuran (DPBF). An enhancement by nearly one order of magnitude was observed for the photosensitized singlet oxygen (1O2) generation of the hybrid systems compared to the same amount of ZnPc in solution caused by the interaction of the npAu surface plasmon resonance and the excited state of the immobilized sensitizer. This interaction was shown to be distance dependent, with decreasing activity for short SAMs with alkyl chain lengths < 6 methylene groups caused by quenching of the excited state via electron transfer as well as decreasing activity for SAMs with n > 8 methylene groups due to decreasing energy transfer for long distances. An unexpected distance dependent behavior was observed for the variation of the peripheral alkyl chain on the photosensitizer revealing a planar orientation of the immobilized photosensitizer on the nanoporous gold surface by a penta-coordinated central zinc ion through interaction with free azide groups from the self-assembled monolayer. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Photocatalytic coatings based on a zinc(II) phthalocyanine derivative immobilized on nanoporous gold leafs with various pore sizes》 was written by Steinebrunner, David; Schnurpfeil, Guenter; Woehrle, Dieter; Wittstock, Arne. Recommanded Product: 1,3-DiphenylisobenzofuranThis research focused onzinc phthalocyanine nanoporous gold leaf pore size photocatalytic coating. The article conveys some information:

A series of singlet oxygen sensitizing hybrid materials is reported consisting of a zinc(II) phthalocyanine (ZnPc) derivative immobilized on nanoporous gold leafs (npAu) with various pore sizes. The resulting photocatalytic coatings exhibit a thickness of around 100 nm and pore sizes between 9-50 nm. Herein, we report the synthesis and characterization of those hybrid materials which were synthesized by functionalization of npAu leafs by an azide terminated alkanethiol self-assembled monolayer (SAM) and subsequent copper catalyzed azide-alkyne cycloaddition (CuAAC). The characterization of the samples morphol. included SEM (SEM), UV-Vis spectroscopy as well as energy dispersive X-ray spectroscopy (EDX). The morphol.-reactivity relationship was investigated employing the hybrid photocatalysts in the photooxidation of diphenylisobenzofuran (DPBF) as selective singlet oxygen quencher. An increasing photocatalytic activity was found for smaller pore sizes up to 15 nm, due to the gain in sp. surface area concomitant with an increasing amount of immobilized photosensitizer, completely dominating the effect of the higher spectral overlap caused by the shift of the plasmon resonance of npAu, until mass transport and diffusion limitation gets predominant for pore sizes below 15 nm.1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 1,3-Diphenylisobenzofuran) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Recommanded Product: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Su, Qianqian; Wei, Han-Lin; Liu, Yachong; Chen, Chaohao; Guan, Ming; Wang, Shuai; Su, Yan; Wang, Haifang; Chen, Zhigang; Jin, Dayong published an article in 2021. The article was titled 《Six-photon upconverted excitation energy lock-in for ultraviolet-C enhancement》, and you may find the article in Nature Communications.Recommanded Product: 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Photon upconversion of near-IR (NIR) irradiation into UV-C (UVC) emission offers many exciting opportunities for drug release in deep tissues, photodynamic therapy, solid-state lasing, energy storage, and photocatalysis. However, NIR-to-UVC upconversion remains a daunting challenge due to low quantum efficiency. Here, we report an unusual six-photon upconversion process in Gd3+/Tm3+-codoped nanoparticles following a heterogeneous core-multishell architecture. This design efficiently suppresses energy consumption induced by interior energy traps, maximizes cascade sensitizations of the NIR excitation, and promotes upconverted UVC emission from high-lying excited states. We realized the intense six-photon-upconverted UV emissions at 253 nm under 808 nm excitation. This work provides insight into mechanistic understanding of the upconversion process within the heterogeneous architecture, while offering exciting opportunities for developing nanoscale UVC emitters that can be remotely controlled through deep tissues upon NIR illumination. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Recommanded Product: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem