《Assemblies of indocyanine green and chemotherapeutic drug to cure established tumors by synergistic chemo-photo therapy》 was published in Journal of Controlled Release in 2020. These research results belong to Hu, Shiqi; Dong, Chengyuan; Wang, Jinqiang; Liu, Kexin; Zhou, Quan; Xiang, Jiajia; Zhou, Zhuxian; Liu, Fusheng; Shen, Youqing. COA of Formula: C20H14O The article mentions the following:
Indocyanine green (ICG), a safe and clin. approved near-IR (NIR) dye, was recently explored as a potential photosensitizer due to its excellent photophys. properties. However, ICG tends to form aggregations in physiol. solution, causing fluorescence quenching, fast blood clearance and thereby inefficient tumor accumulation. Herein, we report ICG-based nanodrug delivery systems formed by self-assembly of ICG and chemotherapeutic drugs without any excipients for combined chemo- and photo-therapy. Taking advantage of the amphiphilic aromatic structure, ICG readily bounded with hydrophobic aromatic drugs such as SN38 and formed well-dispersible nanoparticles, which reduced its aggregation-induced quenching and thus greatly improved its photodynamic efficiency. The loaded hydrophobic drugs elicited chemotherapy synergizing the photodynamic therapy, giving rise to much enhanced antitumor activity in vitro and in vivo against human glioblastoma cells and breast cancer cells upon NIR irradiation The work demonstrates the fabrication of readily translational nanoformulations of hydrophobic drugs using amphiphilic drugs. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6COA of Formula: C20H14O) was used in this study.
1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.COA of Formula: C20H14O
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem