《External-photocatalyst-free visible-light-mediated aerobic oxidation and 1,4-bisfunctionalization of N-alkyl isoquinolinium salts》 was written by Zhou, Youkang; Liu, Wei; Xing, Zhiming; Guan, Jiali; Song, Zhibin; Peng, Yiyuan. Application In Synthesis of 1,3-Diphenylisobenzofuran And the article was included in Organic Chemistry Frontiers in 2020. The article conveys some information:
Visible-light-mediated aerobic alternate transformations of N-alkyl isoquinolinium salts I [X = I, Br, BF4; R = H, OMe, Ph, Cl, Br; R1 = H, Br, Ph, I; R2 = H, Et, naphthalen-1-yl, 2-bromophenyl, etc.] and 2,2′-(butane-1,4-diyl)bis(isoquinolin-2-ium) iodide/quinolinium salts II [R3 = H, Br, Ph, naphthalen-1-yl; R4 = H, naphthalen-1-yl, 3-methylphenyl, 2-phenylethyl; R5 = H, Ph, Br, OMe, Cl] in the absence of any extra added photocatalyst are reported. Here, a highly concise, sustainable and low-cost protocol to produce unsaturated lactams III/IV and 2,2′-(butane-1,4-diyl)bis(isoquinolin-1(2H)-one) from oxidation of their corresponding isoquinolinium salts I or quinolinium salts II using air as an oxidant was developed. Important building blocks for further modification of biol. active isoquinolones, 4-iodoisoquinolinones III and 2,2′-(butane-1,4-diyl)bis(4-iodoisoquinolin-1(2H)-one) were also produced through 1,4-bisfunctionalization of isoquinolinium salts I without the use of any transition metal. Gram-scale synthesis was achieved under sunlight with exposure to the open air. Mechanism studies suggested that singlet oxygen generation triggered by isoquinolinium salts I/quinolinium salts II under visible light irradiation and trace water may lead to multiple pathways for the aerobic transformations of N-alkyl iminium salts. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)
1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Application In Synthesis of 1,3-Diphenylisobenzofuran
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem