Heterocyclic Building Block-benzofuran

23145-07-5, 5-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weigh (950 mg, 4.82 mmol)Soluble12 mL anhydrous ether and cooled to -78 ¡ã C. 1.3 M tert-butyllithium in pentane (7.85 mL, 10.2 mmol) was added dropwise to the supernatant. The reaction was stirred at -78 ¡ã C for 2 hours,DMF (0.8 mL, 10.3 mmol) and diethyl ether (1 mL). After 1 h reaction, quench with ammonium chloride at -78 ¡ã C. Ethyl acetate extraction, anhydrous sulfur Sodium sulfate dried, concentrated, and passed through a silica gel column to give a yield of 75percent., 23145-07-5

23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Shanghai University; Xu Bin; Chen Cheng; (37 pag.)CN107266413; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,10242-12-3

Compound 69 (2.0 g, 9.66 mmol) and beta-alanine methylester¡¤HCl (1.752 g, 12.55 mmol) weredissolved in dimethylformamide (48.3 mL). 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(2.41 g, 12.55 mmol) and 4-dimethylaminopyridine (0.59 g, 4.83 mmol) were added and thereaction was stirred under Ar at room temperature for 2 d. An additional amount of beta-alaninemethylester¡¤HCl (337 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (462 mg), and 4-dimethylaminopyridine (147 mg) were added and stirred for an additional night. The reaction wascooled in an ice bath and then water was added to precipitate the desired compound. The solutionwas filtered to obtain compound 70 (2.82 g, 100% yield), which used without further purification.

As the paragraph descriping shows that 10242-12-3 is playing an increasingly important role.

Reference£º
Article; Reid, Emily E.; Archer, Katie E.; Shizuka, Manami; McShea, Molly A.; Maloney, Erin K.; Ab, Olga; Lanieri, Leanne; Wilhelm, Alan; Ponte, Jose F.; Yoder, Nicholas C.; Chari, Ravi V.J.; Miller, Michael L.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 17; (2019); p. 2455 – 2458;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

133720-60-2, 7-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A stirred solution of diisopropylamine (0.65 mL, 4.7 mmol) in THF (15 L) was cooled to 5C and n-BuLi (2.5 M in hexanes, 1.9 mL, 4.7 mmol) was added dropwise over 5 min. The mixture was stirred at 5C for 15 min and cooled to – 700C. Chlorotrimethylsilane (0.59 mL, 4.7 mmol) was added followed by a solution of 7-bromobenzofuran (0.46 g, 2.35 mmoi) in THF (5 mL). The mixture was stirred at -700C for 1.5 h and poured into sat’d aq NH4Cl (80 mL). The mixture was diluted with 5% aq HCI (20 mL) and extracted with ether (2 x 80 mL). The combined ether extracts were washed with sat’d aq NaHCO3 (50 mL), dried over MgSO4 and concentrated to leave crude 7-bromo-2-(trimethylsilyl)benzofuran (0.62 g, 98%) as a yellow oil.

133720-60-2, As the paragraph descriping shows that 133720-60-2 is playing an increasingly important role.

Reference£º
Patent; VITAE PHARMACEUTICALS, INC.; WO2007/117560; (2007); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

42933-43-7, 2,3-Dihydrobenzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2,3-dihydro-1 -benzofuran-5-amine (33.7 mg, 0.237 mmol) and DIPEA (0.21 mL, 1 .18 mmol) in DCM (1 mL) was cooled to 0¡ãC before crude 2-chloro-benzothiazole-5-carbonyl chloride (92 mg, 0.237 mmol) dissolved in DCM (1 mL) was added. The mixture was stirred at rt for 30 min. The mixture was diluted with DCM (5 mL) and washed with water (5 mL). the organic extract was dried over Na2S04, filtered and concentrated to give the crude title compound (69 mg) as a pale yellow resin; LC-MS: tR= 0.86 min; [M+H]+= 330.97;1H NMR (400 MHz, D6-DMSO): delta 10.28 (s, 1 H), 8.56 (d, J = 1 .1 Hz, 1 H), 8.26 (d, J = 8.5 Hz, 1 H), 8.07 (dd, J, = 1 .5 Hz, J2= 8.5 Hz, 1 H), 7.70 (s, 1 H), 7.45 (dd, J, = 1 .7 Hz, J2= 8.5 Hz, 1 H), 6.76 (d, J = 8.5 Hz, 1 H), 4.54 (t, J = 8.7 Hz, 2 H), 3.21 (t, J = 8.7 Hz, 2 H).

42933-43-7, 42933-43-7 2,3-Dihydrobenzofuran-5-amine 3841102, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOLLI, Martin; BOSS, Christoph; RICHARD-BILDSTEIN, Sylvia; SIEBER, Patrick; (95 pag.)WO2016/207785; (2016); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

41717-32-2,41717-32-2, 1-Benzofuran-2-carbonitrile is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

d) preparation of methyl benzofuran-2-carboximidate hydrochloride 2-Cyanobenzofuran (10.7 g) was dissolved in ethereal HCl (150 ml, 5M) and methanol (12 ml). The resulting mixture was kept at 4 C. for 48 hours. The resulting solid was filtered, washed with ether and dried (13.4 g, 85%). 1 H-NMR (DMSO-d6): 4.30 (s,3H), 7.50 (t,1H), 7.70 (t,1H), 7.80 (d,1H), 7.90 (d,1H), 8.40 (s,1H).

The synthetic route of 41717-32-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Societe de Conseils de Recherches et d’Applications Scientifiques (S.C.R.A.S); US5310930; (1994); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

7169-34-8, Benzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7169-34-8

General procedure: A mixture of 7-substituted 3(2H)-benzofuranones (7a and 7b) (1 eq), substituted aromatic aldehydes (8a-d)(1 eq), in ethanol (10 mL) were added 3 drops of piperidine. The mixture was then heated under reflux for 2 hours. After cooling H2O (20 mL) was added slowly. The crystalline precipitate was separated by filtration and purified by recrystallization from ethanol to afford pure compounds (9a-g).

The synthetic route of 7169-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Paidakula, Suresh; Nerella, Srinivas; Vadde, Ravinder; Kamal; Kankala, Shravankumar; Bioorganic and Medicinal Chemistry Letters; vol. 29; 16; (2019); p. 2153 – 2156;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

496-41-3, Benzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,496-41-3

Preparation 10; 2,3-Dihydro-1-benzofuran-2-carboxylic acidA mixture of 1-benzofuran-2-carboxylic acid (40.0 g, 250.0 mmol) and palladium hydroxide (20 wt. % on carbon, 2.0 g) in acetic acid (400 ml) was heated at 60 C. under a hydrogen atmosphere (80 psi) for 2 h. The mixture was filtered to give a solution of the title compound (39.5 g) in acetic acid.1H-NMR (d6-DMSO): 3.19-3.23 (1H), 3.50-3.54 (1H), 5.16-5.20 (1H), 6.78-6.82 (2H), 7.09-7.12 (1H), 7.18-7.20 (1H)

As the paragraph descriping shows that 496-41-3 is playing an increasingly important role.

Reference£º
Patent; PFIZER LIMITED; US2008/200540; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

24410-59-1, 5-Fluorobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: At -78C, 1.2 mL (1.93 mmol) of a 1.6 M solution of n-butyllithium were slowly added to 175 mg (1.29 mmol) 5-fluorobenzofurane in 10 mL anhydroustetrahydrofurane. The mixture was stirred for 1 h at -78C. 0.52 mL (1.93 mmol) tri-n-buty[tinch[oride was added at -78C. The cooling bath was removed and stirring was continued for 72 h.Methanol was carefully added and the solvent evaporated. The obtained mixture was adsorbed on isolute and purified by flash chromatography. The obtainedmaterial (336 mg) was used directly in the subsequent step 2.Step 2: A mixture of 165 mg of the product from step 1, 100 mg (0.3 mmol) of intermediate 111.1 5, 10.5 mg (0.015 mmol) bis(triphenylphosphine)palladium(II) and 5.7 mg (0.03 mmol) copper(I)iodide in tetrahydrofurane were refluxed for 16 h.The reaction mixture was filtered through a of pad celite. The filtrate wasevaporated and the precipitate was dissolved in tetrahydrofurane. Insolublematerial was filtered off. The filtrate was evaporated and the obtained material was purified by HPLC and preparative thin layer chromatography to give 13 mg of the title compound as solid material., 24410-59-1

The synthetic route of 24410-59-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER INTELLECTUAL PROPERTY GMBH; EIS, Knut; PUeHLER, Florian; ZORN, Ludwig; SCHOLZ, Arne; LIENAU, Philip; GNOTH, Mark, Jean; BOeMER, Ulf; GUeNTHER, Judith; WO2013/41634; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

15832-09-4, 6-Methoxy-3(2H)-benzofuranone is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of benzofuran-3(2H)-one (2.0 mmol), benzaldehyde (2.2mmol) and water (5 mL) was stirred at reflux temperature for 6-10 h. Completion of the reaction was checked on TLC. Then the mixture was allowed to rt and stirred for 1 h. The precipitated solids were filtered, washedwith water (2 ¡Á 5 mL) and dried to give the product., 15832-09-4

The synthetic route of 15832-09-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Venkateswarlu, Somepalli; Murty, Gandrotu Narasimha; Satyanarayana, Meka; Arkivoc; vol. 2017; 4; (2017); p. 303 – 314;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

652-39-1, Combine the two ammonium salt mixtures from Example 1 (8.86 g, 1 eq), NaBH4 (8.37 g, 5 eq), and tetrahydrofuran (123 ml) into the reaction flask and allow the mixture to cool.A solution of BF3 in tetrahydrofuran (30.77 g, 5 eq) was added dropwise and incubated.After the addition was complete, the mixture was stirred and refluxed overnight. Methanol (30 ml) was added, 100 ml of water was added, and the pH was adjusted by adding hydrochloric acid and heating to 60¡ãC. After cooling, add water 300ml, extract with methyl tert-butyl ether, take the aqueous layer, adjust the pH with NaOH, extract with n-butanol, wash with water,It was evaporated to dryness to afford 6.30 g of a mixture of the compound of formula I-1 and the compound of formula I-2 in a yield of 92percent.

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Zhejiang Jiuzhou Pharmaceutical Technology Co., Ltd.; Shen Qirong; Yuan Xiangxiang; Gao Hongjun; Li Yuanqiang; (10 pag.)CN107915672; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem