Heterocyclic Building Block-benzofuran

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81742-10-1,3,6-Dichlorotrimellitic Anhydride,as a common compound, the synthetic route is as follows.,81742-10-1

General procedure: The synthetic steps of MPc (COOH) 4Cl8 (Scheme 1). A mixture of1.0025 g of 3,6-dichloro-1,2,4-benzenetricarboxylic anhydride,6.0000 g of urea, 0.3654 g of Mn(CH3COOH)2¡¤4H2O, 0.25 g of NH4Cland 0.1200 g of (NH4)2Mo2O7 in 100 mL three-necked flask was heatedat 140 C for 0.5 h with magnetic stirrer and reflux condenser, and thenkept at 220 C for 6 h under ambient air conditions. The by-productswere washed with water followed by 6 mol L-1 hydrochloric acid forseveral times. Then the purification of blue solid was achieved by refluxingwith 150 mL of acetone and trichloromethane about 12 h.The obtained octachloro-tetracarboxamide phthalocyanine was hydrolyzedwith 100 mL of 2.0 mol¡¤L-1 sodium hydroxide solution at 100 C for 12 h, filtered, and the filtrate was adjusted to pH=1 withhydrochloric acid, a large amount of precipitates were produced andfiltered by the G4 sand core funnel, the filter cake was washed first withdeionized water until the filtrate was neutral. Then the filter cake waswashed with in proper order. The solid product was vacuum dried at100 C. The as-prepared MPcTcCl8 were washed by chloroform,ethanol, ether, acetone and THF respectively, dried in vacuum overnightat 100 C.

The synthetic route of 81742-10-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gao, Min; Zhang, Gai; Tian, Min; Liu, Bulei; Chen, Weixing; Inorganica Chimica Acta; vol. 485; (2019); p. 58 – 63;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.77095-51-3,Benzofuran-6-carboxylic acid,as a common compound, the synthetic route is as follows.,77095-51-3

Benzofuran carboxylic acid (II) (1.0 g, 6.17 mmol, 1.0 equiv), DMF (0.01 eq) and THF (10 mL, 10 vol) is charged to a two-neck round bottom flask under nitrogen atmosphere. Oxalyl chloride (1.1 mL, 13.34 mmol, 2.0 equiv) is slowly added while keeping the temperature between 20 to 30 C. The resulting solution was stirred at 20-30 C. for over 2 hr. When the reaction was complete as determined by TLC analysis, the solvent was removed under reduced pressure and the acid chloride of compound of Formula II (Formula IIb) was stored under nitrogen.

As the paragraph descriping shows that 77095-51-3 is playing an increasingly important role.

Reference£º
Patent; ScinoPharm Taiwan, Ltd.; WU, Ming-Chih; HSIAO, Tsung-Yu; US2019/2445; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

69999-16-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69999-16-2,2,3-Dihydrobenzofuranyl-5-acetic acid,as a common compound, the synthetic route is as follows.

Preparation 5 5-(2-Hydroxyethyl)-2,3-dihydrobenzofuran STR52 A solution of (2,3-dihydrobenzofuran-5-yl)acetic acid (4.9 g–see EP-A-132130) in anhydrous tetrahydrofuran (50 ml) was added dropwise over 10 minutes to a stirred suspension of lithium aluminium hydride (1.57 g) in anhydrous tetrahydrofuran (50 ml) at 0 C. The mixture was allowed to warm to room temperature and stirred for 1 hour. Water (1.5 ml) was cautiously added dropwise followed by 10% aqueous sodium hydroxide solution (1.5 ml) and water (4.5 ml). The mixture was filtered and the inorganic salts washed with ethyl acetate. The filtrate and washings were combined and evaporated to give the title compound as an oil, yield 3.3 g. 1 H-NMR (CDCl3) delta=7.10 (s, 1H); 7.00 (d, 1H); 6.75 (m, 1H); 4.65-4.55 (m, 2H); 3.90-3.75 (m, 2H); 3.30-3.15 (m, 2H); 2.90-2.80 (m, 2H); 1.85-1.75 (brs, 1H) ppm.

As the paragraph descriping shows that 69999-16-2 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc.; US5397800; (1995); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

To a solution of the product from Step B (2g) in ether (20ml) at-78¡ãC was added t-BuLi dropwise. After stirring for 20min, DMF (950mg) was added dropwise and the mixture was stirred at-25¡ãC for 3hrs and then warmed to room temperature overnight. Saturated ammonium chloride was added and the solution was extracted with ether. The ether layer was washed with brine, dried with MgS04, filtered and concentrated in vacuo to give 980mg of crude product (67percent)., 23145-07-5

The synthetic route of 23145-07-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/68460; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.,652-39-1

General procedure: In a 25mL beaker, anhydride (1 mmol), semicarbazide (1mmol) were roughly mixed with montmorillonite K10 (1 g)and after 3 min of mechanical stirring, the mixture was irradiated into a single mode focused microwave reactor with continuous rotation.for18 min (optimized time) at 170 ¡ãC. Upon completion of the reaction, monitored on TLC (nhexane:ethyl acetate, 3:1), the product was extracted in dichloromethane(2 Chi 25 mL), solvent removal of the solid residue was crystallized from EtOH to yield compounds a-l.

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Marvi, Omid; Nikpasand, Mohammad; Letters in Organic Chemistry; vol. 10; 5; (2013); p. 353 – 357;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

127264-14-6, 5-(2-Bromoethyl)-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compound (3S) -pyrrolidin-3-yl (2R) -cyclopentyl (hydroxy) phenyl acetate (0.2 g, 0.69 mM) was dissolved in acetonitrile (5. 0ML). To the reaction mixture, 5- (2- BROMOETHYL) -2, 3-DIHYDRO-1-BENZOFURAN (0.173 G, 0.76 MM), POTASSIUM CARBONATE (0.29 G, 2.01 mM) and potassium iodide (0.23 g, 1.38 mM) were added and the reaction mixture was heated under reflux for 8 hours and then cooled to room temperature. Acetonitrile was evaporated under vacuum. The residue was partitioned between ethyl acetate (30.0 ml) and water (30.0 ml). The organic layer was washed with water and brine solution. It was dried over anhydrous NA2S04 and concentrated. The residue was purified by silica gel column chromatography using 30percent ethyl acetate in hexane to get the title compound. Yield = 46percent (0.14 g, 0.32 mM). 1;H NMR (CDCl3): delta 7.66 (D, J=1. 5 Hz, 2H), 7.28-7.36 (M, 3H), 7.05 (d, J=8 Hz, 1H), 6.94 (d, J=8 Hz, 1H), 6.71 (d, J=8 Hz, 1H), 5.20-5.23 (M, 1H), 4.52-4.58 (M, 2H), 3.80 (s, 1H), 3.18 (t, J=9 Hz, 2H), 2.70-2.92 (M, 8H), 2.50-2.70 (M, 1H), 2.04-2.15 (M, 1H), 1.25-1.61 (M, 9H)., 127264-14-6

127264-14-6 5-(2-Bromoethyl)-2,3-dihydrobenzofuran 21831160, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; RANBAXY LABORATORIES LIMITED; WO2004/56767; (2004); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59434-19-4,4-Aminophthalide,as a common compound, the synthetic route is as follows.,59434-19-4

4-Aminoisobenzofuran-1(3H)-one (600 mg, 4 mmol), picolinaldehyde (856 mg, 8 mmol) and 1 g of MgSO4 were added into 40 mL of dichloromethane and the mixture was stirred under reflux overnight, then the mixture was evaporated under reduced pressure and the residues was dried in vacuum. 476 mg of (E)-4-(pyridin-2-ylmethyleneamino) isobenzofuran-1(3H)-one was obtained. A mixture of (E)-4-(pyridin-2-ylmethyleneamino) isobenzofuran-1(3H)-one (476 mg, 2 mmol), benzaldehyde (212 mg, 2 mmol), sodium methanolate (432 mg, 8 mmol) and ethyl propionate (40 mL) was stirred at room temperature overnight. Then the resulting mixture was evaporated under reduced pressure and extracted with ethyl acetate (100 mL¡Á4) and concentrated. The crude product was purified by column chromatography (silica gel, petroleum ether:ethyl acetate 20:1 to 5:1) to give 30 mg of methyl 4-oxo-3-phenyl-2-(pyridin-2-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate; yield 5%. LC-MS (ESI) m/z: 459 (M+1)+.

As the paragraph descriping shows that 59434-19-4 is playing an increasingly important role.

Reference£º
Patent; LEAD THERAPEUTICS, INC.; US2010/35883; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-16-1,Benzo[b]furan-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of amine (6) (100 mg,0.407 mmol) in ethanol was added amines (7.1-7.9) (0.407mol) followed by anhydrous sodium sulphate (0.407 mmol) and stirred at 50 C for 1 h. The hot homogenous solution was filtered and cooled to 5 C to isolate the corresponding imines (8.1-8.9) in quantitative yields.

4265-16-1, The synthetic route of 4265-16-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sreedhar, Pandiri; Srinivas, Gudipati; Raju, Rallabandi Madhusudan; Asian Journal of Chemistry; vol. 28; 7; (2016); p. 1603 – 1606;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37418-88-5,4-Hydroxyisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

A 50-mL round bottom flask was charged with phthalic anhydride Comppund 1a (1.1 g, 6.70 mmol) and dry toluene (30 mL). Compound 23h (2.2 g, 6.79 mmol) and triethylamine (1.2 mL, 8.61 mmol) were added to the mixture. A Dean-Stark trap was attached to the flask and the mixture was refluxed for 24 h. The mixture was cooled to room temperature, diluted with dichloromethane (200 mL), and washed with 1.0 N HCI (100 mL). The organic layer was dried using MgSC>4, filtered through Celite.(R)., and concentrated in vacuo, to give 3.1 g (98percent) of Compound 23i as a yellow solid. 1H NMR (300 MHz, CDCI3) delta 7.66-7.70 (m, 1 H), 7.52-7.57 (m, 1 H), 7.06-7.16 (m, 1 H), 6.79-6.88 (m, 3 H), 5.16-5.21 (m, 1 H),3.88 (s, 3 H), 3.85 (s, 3 H), 3.06-3.19 (m, 1 H), 2.49-2.56 (m, 1 H), 2.26-2.33 (m, 1 H), 1.46-1.56 (m, 2 H), and 1.42 (s, 9 H).

37418-88-5, As the paragraph descriping shows that 37418-88-5 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2007/81995; (2007); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4- (2-Aminoethoxy) benzoic acid methyl ester hydrochloride (78.90 g, 0.340 mol) and 3- methylbenzofuran-2-carboxylic acid (60.0 g, 0.340 mol) were suspended in acetonitrile (360 ml) and cooled to 0-5 C. Pyridine (137.6 mL, 1.702 mol) was added quickly. A solution of phosphorous oxychloride (52.2 g, 0.340 mol) in acetonitrile (60 ML) was added drop wise over thirty to forty-five minutes with the temperature kept below 20 C. The reaction mixture was allowed to stir for one hour and warm slowly to ambient temperature. After completion of reaction, the solution was added to a rapidly stirred 0-5 C mixture of chlorobenzene (1000 ML) and IN hydrochloric acid (1000 ml). The reaction mixture was stirred rapidly and allowed to warm to room temperature. The organic layer was washed with water, 3% potassium hydroxide, and again with water. Chlorobenzene (100 ML) was added to the washed organic layer. Solvent (100 ML) was then distilled at atmospheric pressure until the pot temperature reached 132 C. After cooling to ambient temperature, 4- {2- [ (3-METHYLBENZOFURAN-2- carbonyl) amino] ethoxy} benzoic acid methyl ester was stored in solution for use in the next step., 24673-56-1

As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.

Reference£º
Patent; AXYS PHARMACEUTICALS INC.; WO2004/92115; (2004); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem