Tag: M.W:100-200

652-39-1, 4-Fluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,652-39-1

The subtitle compound is prepared according to the procedure adapted from C.G. Thomson et a.., Bioorg. Med. Chern. Letters 2006, 16(5), 1388-1391: 3-fluorophthalic acid anhydride (29.7 mmol) is reacted with phenyl acetic acid (59.4 mmol) in Ac2O (16 mL) in the presence of NEt3 (21 mL) at reflux, followed by treatment with 30percent sol. of NaOMe in MeOH (48 mL) at reflux.

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; FRETZ, Heinz; GATFIELD, John; ISLER, Markus; KIMMERLIN, Thierry; KOBERSTEIN, Ralf; LYOTHIER, Isabelle; MONNIER, Lucile; POTHIER, Julien; VALDENAIRE, Anja; WO2013/68785; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13196-11-7,Benzofuran-6-ol,as a common compound, the synthetic route is as follows.

Tribromide (2.86 g, 10 mmol) was dissolved in chloroform (10 mL)Cooled to -50 , slow6-hydroxy-2,3-dihydrobenzofuran (1.36 g, 10 mmol) and triethylamine (1.212 g, 12Mmol) in dichloromethane (10 mL)The After completion of the dropwise addition, the cold bath was removed and the mixture was stirred at 25 C2 hours. The reaction was further cooled to -60 C and L-alanine-4-fluorobenzyl ester hydrochloride was addedSalt (2.1 g, 9 mmol) was added dropwise to a solution of triethylamine (2.53 g, 25 mmol) in dichloromethane (5ML). After completion of the dropwise addition, the cold bath was removed and the mixture was stirred at 25 C for 2 hours. Further the reaction is carried outWas cooled to -60 C and pentafluorophenol (1.66 g, 9 mmol) and triethylamine (1.52 g, 15Mmol) in dichloromethane (10 mL). After completion of the dropwise addition, the cold bath was removed and the mixture was stirred at 25 C6 hours. The reaction was complete and the reaction system was poured into ice water and extracted with dichloromethane. CollectionAnd the organic phase was washed with saturated brine aqueous solution, dried and concentrated by filtration to give the intermediate compound(6-fluorobenzyl) -2 – ((pentafluorophenoxy) (benzofuran-6-oxy) phosphoryl) amino)Propionate.

13196-11-7, The synthetic route of 13196-11-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Kelun Pharmaceutical Research Institute Co., Ltd.; Liu, Gang; Yu, Nan; Wu, Yongyong; Tang, Zuijian; Zheng, Xiaozhou; Chen, Qiangqiang; Deng, Hanwen; Duan, Xiaofan; Song, Shuai; Yang, Long; Li, Shai; Huang, Haitao; Zhang, Yitao; Zhao, Mingliang; Deng, Hua; Zhong, Wei; Li, Donghong; Ceng, Hong; Guo, Xianfen; Song, Hongmei; Tao, Lihua; Wang, Lichun; Wang, Jingyi; Other inventors request an unlisted name; (127 pag.)CN106554382; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

196799-45-8, 2,3-Dihydrobenzofuran-7-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,3-Dihydro-benzofuran-7-carbaldehyde (1.50 g, 10.20 mmol) was dissolved in ether, then cooled to 0 C., NaBH4 (400 mg, 10.57 mmol) in MeOH (5.00 mL) was added. The resulting reaction mixture was stirred for 30 min, then saturated ammonium chloride was added. The mixture was extracted with ether, and the combined organic phases were washed with brine, then dried over magnesium sulfate and concentrated to afford the desired alcohol

196799-45-8, 196799-45-8 2,3-Dihydrobenzofuran-7-carbaldehyde 2795018, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Allergan, Inc.; US2008/255230; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-10-1,5-Chlorobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

5-chlorobenzofuran-2-carboxylic acid (500 mg, 2.5 mmol) was added to thionyl chloride (5 mL) and heated under reflux for 2 hrs. Solvent was removed under reduced pressure to obtain a white solid, which then used in the next reaction without further purification (510 mg). 1H NMR (400 MHz, Chloroform-d) delta 7.76 (d, J=0.9 Hz, 1H), 7.72 (dd, J=2.0, 0.7 Hz, 1H), 7.56-7.48 (m, 2H).

10242-10-1, As the paragraph descriping shows that 10242-10-1 is playing an increasingly important role.

Reference£º
Patent; The University of North Carolina at Chapel Hill; Juliano, Rudolph L.; Kreda, Silvia M.; Wang, Ling; Ming, Xin; James, Lindsey Ingerman; Ariyarathna, Ranathunga Arachchillage Yamuna Kumari; (53 pag.)US2019/343868; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18761-31-4,5-Nitrobenzofuran,as a common compound, the synthetic route is as follows.

(a) 2,3-Dihydrobenzo[b]furan-5-ylamine. To a 150 mL round-bottomed flask was added 5-nitrobenzofuran, Example 38(d), (250 mg, 1.5 mmol), EtOAc (16 mL) and 10percent Pd on carbon (33 mg, Aldrich). The suspension was stirred at 25¡ã C. under 1 atm H2 for 24 h, then purged with N2, filtered through Celite and concentrated in vacuo to provide the aniline as a red-brown solid. MS (ESI, pos. ion) m/z: 136 (M+1).

18761-31-4, The synthetic route of 18761-31-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bo, Yunxin Y.; Chakrabarti, Partha P.; Chen, Ning; Doherty, Elizabeth M.; Fotsch, Christopher H.; Han, Nianhe; Kelly, Michael G.; Liu, Qingyian; Norman, Mark Henry; Ognyanov, Vassil I.; Wang, Xianghong; Zhu, Jiawang; US2003/195201; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

652-39-1, To a stirred solution of 4-fluoroisobenzofuran-1,3-dione (25 g, 150 mmol, CAS652-39-1) in DMF (100 mL) was added L-glutamine (22 g, 150 mmol) at rt. The resulting reaction mixture was heated to at 90 C. and stirred for 2 h. The reaction mixture was then evaporated under reduced pressure, transferred into 4 N aqueous HCl solution and the resulting mixture was stirred for 36 h at rt. The solid precipitate was then filtered off, washed with cold water and dried under reduced pressure to give 5-amino-2-(4-fluoro-1,3-dioxoisoindolin-2-yl)-5-oxopentanoic acid as a white solid (28 g, 63%). LC-MS (ESI+) m/z 295 (M+H)+.

The synthetic route of 652-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57319-65-0, 6-Aminoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of 2-(3,4-bis(3,4-dimethoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid 1 (70 mg, 0.16 mmol) and EDCI (47 mg, 0.25 mmol) in dry CH2Cl2 (5 mL) at 0 C under N2 atmosphere was added DMAP (30 mg, 0.25 mmol) and 14, 15, 18, or 19 (0.2 mmol) in batch over 10 min. The reaction mixture was stirred overnight while the reaction temperature rose to room temperature naturally. The solution was diluted with CH2Cl2 (20 mL), washed with brine, and dried over anhydrous MgSO4. The solvent was evaporated to dryness to give the crude residue. The residue was purified by flash chromatography on silica gel (EtOAc/PE = 2:1, v/v) to afford the desired compound 16, 17. 2-(3,4-Bis(3,4-dimethoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(3-oxo-1,3-dihydroisobenzofuran-4-yl)-acetamide (16) Yield 69%; mp 244-246 C; 1H NMR (CDCl3, 500 MHz) d: 8.4 (s,1H), 8.0 (d, J = 8.2 Hz, 1H), 7.94 (s, 1H), 7.42 (d, J = 8.3 Hz, 1H), 7.23 (d, J = 8.4 Hz, 2H), 7.06 (s, 3.70 (s, 6H); 13C NMR (CDCl3, 126 MHz) d: 170.7, 164.9, 150.5, 148.7, 142.1, 138.5, 134.5, 126.1, 123.6, 122.7, 121.0, 116.1, 112.5, 110.9, 69.7, 55.9, 55.8, 41.8, 29.6; HRMS calcd for (C30H26O9N2+H)+ 559.1711, found 559.1704., 57319-65-0

As the paragraph descriping shows that 57319-65-0 is playing an increasingly important role.

Reference£º
Article; Wang, Zhen; Wong, Iris L.K.; Li, Fu Xing; Yang, Chao; Liu, Zhen; Jiang, Tao; Jiang, Ting Fu; Chow, Larry M.C.; Wan, Sheng Biao; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5566 – 5573;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79002-39-4,Benzofuran-5-carbonitrile,as a common compound, the synthetic route is as follows.

79002-39-4, EXAMPLE 20 Preparation of 1-benzofuran-5-carbaldehyde To a solution of 1-benzofuran-5-carbonitrile (5.0 g, 34.9 mmol) in CH2Cl2 under nitrogen at -15 to -20 C. was added DIBAL-H (41.9 mL, 41.9 mmol, 1 M/heptane) and the temperature was maintained below -15 C. After addition was complete, the reaction mixture was stirred at -15 to -20 C. for an additional 10 min. The reaction mixture was quenched via dropwise addition of aqueous 2N HCl. The organic layer was separated and washed with water, dried over sodium sulfate, and concentrated to give 4.0 g (78%) of 1-benzofuran-5-carbaldehyde as a yellow oil.

The synthetic route of 79002-39-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Cole, Derek Cecil; Asselin, Magda; Boschelli, Diane Harris; Wissner, Allan; Wang, Yanong Daniel; Prashad, Amarnauth Shastrie; Dushin, Russell; US2007/287738; (2007); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

77095-51-3, Benzofuran-6-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

77095-51-3, Add HATU (418 mg, 1.1 mmol) and DIPEA (390 mg, 3 mmol) to a vigorously stirred solution of benzofuran-6-carboxylic acid (178 mg, 1.1 mmol) in DMF (5 mL). After the reaction mixture was reacted at room temperature for 1 hour, (S)-2-(8-chloro-2,3-dihydro-1H-pyrrole[3,2,1-ij]-quinazoline-7-carbonylamino)- 3-(3-(Methanesulfonyl)phenyl)propanoic acid benzyl ester trifluoroacetate (649 mg, 1 mmol), the mixture was stirred at room temperature for 2 hours. Ethyl acetate was added (100 mL), sequentially washed with water (20mL), saturated brine (20mL) was washed, and the organic phase was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated, the residue was purified by flash chromatography, Petroleum ether with 50% ethyl acetate in hexanes to afford the desired product as a white solid (661mg, 0.95mmol 95%).

The synthetic route of 77095-51-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Weimou Bio-technology (Shanghai) Co., Ltd.; Shen Wang; Ding Yue; Wang Jiangfeng; Jiang Hao; Chen Fuli; Wu Xinglong; Li Cunfei; Yang Liguo; Hu Biao; (34 pag.)CN109721605; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-methyl-benzofuran-2-carboxylic acid (0.98 g, 5.6 mmol) and catalytic amount of DMF (5 drops) in THF (25 ml) was added oxalyl chloride (0.53 ml, 6.1 mmol). After stirring the solution for 1 h at room temperature, methanol (20 ml) and TEA (7.0 ml) were added. The reaction mixture was stirred overnight at room temperature, then concentrated and dissolved in ethyl acetate (100 ml) and washed with aqueous sodium bicarbonate solution (100 ml). The organic layer was dried over sodium sulfate and concentrated to provide crude methyl 3-methylbenzofuran-2-carboxylate (1.0 g, 5.3 mmol) as a tan solid, which was used without further purification., 24673-56-1

24673-56-1 3-Methylbenzofuran-2-carboxylic acid 600591, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; AXYS PHARMACEUTICALS, INC.; WO2005/19174; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem