57319-65-0, 6-Aminoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a stirred solution of 2-(3,4-bis(3,4-dimethoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid 1 (70 mg, 0.16 mmol) and EDCI (47 mg, 0.25 mmol) in dry CH2Cl2 (5 mL) at 0 C under N2 atmosphere was added DMAP (30 mg, 0.25 mmol) and 14, 15, 18, or 19 (0.2 mmol) in batch over 10 min. The reaction mixture was stirred overnight while the reaction temperature rose to room temperature naturally. The solution was diluted with CH2Cl2 (20 mL), washed with brine, and dried over anhydrous MgSO4. The solvent was evaporated to dryness to give the crude residue. The residue was purified by flash chromatography on silica gel (EtOAc/PE = 2:1, v/v) to afford the desired compound 16, 17. 2-(3,4-Bis(3,4-dimethoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(3-oxo-1,3-dihydroisobenzofuran-4-yl)-acetamide (16) Yield 69%; mp 244-246 C; 1H NMR (CDCl3, 500 MHz) d: 8.4 (s,1H), 8.0 (d, J = 8.2 Hz, 1H), 7.94 (s, 1H), 7.42 (d, J = 8.3 Hz, 1H), 7.23 (d, J = 8.4 Hz, 2H), 7.06 (s, 3.70 (s, 6H); 13C NMR (CDCl3, 126 MHz) d: 170.7, 164.9, 150.5, 148.7, 142.1, 138.5, 134.5, 126.1, 123.6, 122.7, 121.0, 116.1, 112.5, 110.9, 69.7, 55.9, 55.8, 41.8, 29.6; HRMS calcd for (C30H26O9N2+H)+ 559.1711, found 559.1704., 57319-65-0
As the paragraph descriping shows that 57319-65-0 is playing an increasingly important role.
Reference£º
Article; Wang, Zhen; Wong, Iris L.K.; Li, Fu Xing; Yang, Chao; Liu, Zhen; Jiang, Tao; Jiang, Ting Fu; Chow, Larry M.C.; Wan, Sheng Biao; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5566 – 5573;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem