Downstream synthetic route of 10242-10-1

10242-10-1, As the paragraph descriping shows that 10242-10-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-10-1,5-Chlorobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

5-chlorobenzofuran-2-carboxylic acid (500 mg, 2.5 mmol) was added to thionyl chloride (5 mL) and heated under reflux for 2 hrs. Solvent was removed under reduced pressure to obtain a white solid, which then used in the next reaction without further purification (510 mg). 1H NMR (400 MHz, Chloroform-d) delta 7.76 (d, J=0.9 Hz, 1H), 7.72 (dd, J=2.0, 0.7 Hz, 1H), 7.56-7.48 (m, 2H).

10242-10-1, As the paragraph descriping shows that 10242-10-1 is playing an increasingly important role.

Reference£º
Patent; The University of North Carolina at Chapel Hill; Juliano, Rudolph L.; Kreda, Silvia M.; Wang, Ling; Ming, Xin; James, Lindsey Ingerman; Ariyarathna, Ranathunga Arachchillage Yamuna Kumari; (53 pag.)US2019/343868; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem