With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13196-11-7,Benzofuran-6-ol,as a common compound, the synthetic route is as follows.
Tribromide (2.86 g, 10 mmol) was dissolved in chloroform (10 mL)Cooled to -50 , slow6-hydroxy-2,3-dihydrobenzofuran (1.36 g, 10 mmol) and triethylamine (1.212 g, 12Mmol) in dichloromethane (10 mL)The After completion of the dropwise addition, the cold bath was removed and the mixture was stirred at 25 C2 hours. The reaction was further cooled to -60 C and L-alanine-4-fluorobenzyl ester hydrochloride was addedSalt (2.1 g, 9 mmol) was added dropwise to a solution of triethylamine (2.53 g, 25 mmol) in dichloromethane (5ML). After completion of the dropwise addition, the cold bath was removed and the mixture was stirred at 25 C for 2 hours. Further the reaction is carried outWas cooled to -60 C and pentafluorophenol (1.66 g, 9 mmol) and triethylamine (1.52 g, 15Mmol) in dichloromethane (10 mL). After completion of the dropwise addition, the cold bath was removed and the mixture was stirred at 25 C6 hours. The reaction was complete and the reaction system was poured into ice water and extracted with dichloromethane. CollectionAnd the organic phase was washed with saturated brine aqueous solution, dried and concentrated by filtration to give the intermediate compound(6-fluorobenzyl) -2 – ((pentafluorophenoxy) (benzofuran-6-oxy) phosphoryl) amino)Propionate.
13196-11-7, The synthetic route of 13196-11-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sichuan Kelun Pharmaceutical Research Institute Co., Ltd.; Liu, Gang; Yu, Nan; Wu, Yongyong; Tang, Zuijian; Zheng, Xiaozhou; Chen, Qiangqiang; Deng, Hanwen; Duan, Xiaofan; Song, Shuai; Yang, Long; Li, Shai; Huang, Haitao; Zhang, Yitao; Zhao, Mingliang; Deng, Hua; Zhong, Wei; Li, Donghong; Ceng, Hong; Guo, Xianfen; Song, Hongmei; Tao, Lihua; Wang, Lichun; Wang, Jingyi; Other inventors request an unlisted name; (127 pag.)CN106554382; (2017); A;,
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