64169-34-2, 5-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 5-bromoisobenzofuran-1(3H)-one (21.3 g, 100 mmol) in DCM (200 mL) was added diisobutylaluminum hydride (184 g, 130 mmol) at -78 C. The reaction was stirred at -78 C. until the reaction was complete (?2 h). 10 mL water was added, and 10 mL 4M NaOH (aq.) was added, then 40 mL was water was added, the mixture was stirred at room temperature for 30 mins. The mixture was filtered, the filtrate was concentrated. The resulting solid was purified by flash column chromatography (petroleum ether:EtOAc 100:0 to 80:20) to provide 285 5-bromo-1,3-dihydroisobenzofuran-1-ol (13 g, 60.4 mol) as a white solid. MS (ESI): m/z 196.9 [M-16+1]+., 64169-34-2
As the paragraph descriping shows that 64169-34-2 is playing an increasingly important role.
Reference£º
Patent; Sunovion Pharmaceuticals Inc.; XIE, Linghong; HEFFERNAN, Michele L.R.; JONES, Philip Glyn; HANANIA, Taleen G.; (95 pag.)US2018/30064; (2018); A1;,
Benzofuran – Wikipedia
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