Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95333-17-8,Benzofuran-4-carbonitrile,as a common compound, the synthetic route is as follows.

In a 100 mL single-necked flask, benzofuran-4-carbonitrile C1-1e (1.1 g, 7.68 mmol), BOC anhydride (2.5 g, 11.52 mmol), methanol (50 mL), and 10% palladium carbon (2 g, containing 50 %water). The reaction mixture was purged with hydrogen for 5 minutes, vented three times with a hydrogen balloon, and stirred at 60 C. for 18 hours under a hydrogen balloon. The mixture was filtered through celite, washed with methanol (50 mL X 2), and the filtrate was concentrated under reduced pressure.Compound C1-1f (1.5 g, 79% yield) was obtained., 95333-17-8

Big data shows that 95333-17-8 is playing an increasingly important role.

Reference£º
Patent; Shanghai Qingyu Pharmaceutical Technology Co., Ltd.; Zou Bin; Ma Shichao; Wang Xiang; Zhang Zhongguo; (92 pag.)CN110563722; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

7169-34-8, Benzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7169-34-8, General procedure: In the following syntheses, coumaranone (1.00 mmol) and aldehyde (1.00 mmol) were combined in a microwave vial. 1 mL of the deep eutectic solvent formed from a 1:2 molar ratio of choline chloride and urea was added. The tube was then microwaved at 90 C for 30 minutes. At this point, the reaction was allowed to cool to room temperature and partitioned between water and methylene chloride. The organic layer was separated and concentrated to dryness in vacuo to afford the desired aurone. Further purification was performed as noted.

7169-34-8 Benzofuran-3(2H)-one 23556, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Taylor, Kimberly M.; Taylor, Zachary E.; Handy, Scott T.; Tetrahedron Letters; vol. 58; 3; (2017); p. 240 – 241;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24673-56-1,3-Methylbenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

A. N,3-dimethylbenzofuran-2-carboxamide[0218] A mixture of 3-methylbenzofuran-2-carboxylic acid (1.0 kg, 5.676mol) in methylene chloride (5.8L) and DMF (5mL) was chilled to ~ 2 0C. A solution of oxalyl chloride (864g, 6.81 mol) was added to the reaction mixture keeping the temperature below 10 0C, over a period of 2 hrs. A vigorous evolution of a gas was observed. The reaction mixture was stirred overnight under nitrogen at room temperature and then refluxed for 3 hrs. All of the solids were dissolved to give a brown color solution. HPLC analysis of an aliquot indicated that the reaction was complete. The mixture was concentrated on a rotary evaporator and the residual oxalyl chloride was chased with DCM (2L). The solid product was re-dissolved in DCM (6L) in a round bottom flask (1 OL) and chilled to ~ – 50C. A solution of methyl amine (40% in water, 1.7L, 3.5 eq, 19.86 mol) was carefully added to the acid chloride solution while keeping the temperature below 8 0C then stirred overnight at room temperature. Analysis of an aliquot indicated that the reaction was complete. Water (8.0L) was added to the reaction mixture, the layers were separated, the aqueous layer was back extracted with DCM (2×3 L), the combined organic layer was washed with water (4L) and dried over Na2SO4. The organic layer was filtered, the filtrate was concentrated and traces of DCM were co evaporated with heptanes (2L). The heptanes slurry was filtered and the cake was washed with heptanes (2x2L). All the brown color was removed in the heptane filtrate. The solid product was dried under high vacuum overnight to a constant weight. Yield of the title compound was 1.015 kg (94.5%. 1H NMR (CDCl3) : delta (ppm) 8.45 (s,lH), 7.61 (d, IH), 7.41 (m, 2 H), 7.30 (m, 1 H), 3.03 (d, 2 H), 2.63 (s, 3 H). HPLC: 99.0 area% (Rtau = 7.91 min)

24673-56-1, The synthetic route of 24673-56-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AFFINIUM PHARMACEUTICALS, INC.; WO2008/98374; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37418-88-5,4-Hydroxyisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

A mixture of 3-hydroxyphthalic anhydride(33.5mg, 0.2mmol), 3,5-bis(trifluoromethyl)benzyl amine(62mg, 0.2mmol) and chlorobenzene(5mL) was refluxed for 3 hours under argon atmosphere. After the reaction mixture was cooled to room temperature, the solvent was evaporated under reduced pressure and the obtained residue was crystallized n-hexane/ethyl acetate to give the title compound(68.5mg, 85.2percent) as a white crystal.1H-NMR(CDCl3): delta 4.90(2H, s), 7.19(1H, dd, J=8.4, 0.6Hz), 7.41(1H, dd, J=7.2, 0.6Hz), 7.61(1H, dd, J=8.4, 7.2Hz), 7.75(1H, brs), 7.82(1H, brs), 7.86(2H, s)., 37418-88-5

As the paragraph descriping shows that 37418-88-5 is playing an increasingly important role.

Reference£º
Patent; Institute of Medicinal Molecular Design, Inc.; EP1512396; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

1914-60-9, 2,3-Dihydrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of 7 (1 eq) and 1,1?-carbodiimidazole (1.2 eq) in anhydrous THF was stirred for 1h then substituted aniline (0.9 eq) was added at room temperature. After stirring for 14 h, solvent was evaporated then the mixture acidified with 6N HCl to pH 2. The mixture was extracted with EtOAc (3 ¡Á 20 mL). The combined extracts were dried over anhydrous Na2SO4and the solvent was evaporated. After evaporation, the residue was purified by column chromatography (EtOAc/hexane = 1:3 – 1:50).

1914-60-9, The synthetic route of 1914-60-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Choi, Minho; Jo, Hyeju; Park, Hyun-Jung; Sateesh Kumar, Arepalli; Lee, Joonkwang; Yun, Jieun; Kim, Youngsoo; Han, Sang-Bae; Jung, Jae-Kyung; Cho, Jungsook; Lee, Kiho; Kwak, Jae-Hwan; Lee, Heesoon; Bioorganic and Medicinal Chemistry Letters; vol. 25; 12; (2015); p. 2545 – 2549;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35700-40-4,2,3-Dihydrobenzofuran-7-carboxylic acid,as a common compound, the synthetic route is as follows.

Method B To an ice-cooled solution of 2,3-dihydrobenzo[b]furan-7-carboxylic acid (15a) (0.33 g, 2.0 mmol) in 3 ml of acetic acid there was added dropwise 0.6 ml of HNO3. The mixture was stirred in a warm oil bath (70C) for 24 hours, and then poured into water. After cooling, the product was collected on a filter to give 0.21 g of solid (50.2%). This was recrystallized from ethyl acetate to afford 0.14 g (33.5%) of 15k , mp 249-251.5C., 35700-40-4

35700-40-4 2,3-Dihydrobenzofuran-7-carboxylic acid 2795014, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Erbamont Inc.; EP234872; (1991); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

7169-34-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7169-34-8,Benzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.

General procedure: To a solution of benzofuran-3(2H)-one (134mg, 1mmol) in dry methanol (20mL) at room temperature was added the appropriate aldehyde (1.2mmol) and Al2O3 (1mmol). The mixture was refluxed, under N2, for 48h. After, the solvent was removed and the solid residue was dissolved in CH2Cl2. The organic layer was washed with water, dried with anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product.

7169-34-8 Benzofuran-3(2H)-one 23556, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Carrasco, Marta P.; Newton, Ana S.; Goncalves, Lidia; Gois, Ana; Machado, Marta; Gut, Jiri; Nogueira, Fatima; Haenscheid, Thomas; Guedes, Rita C.; Dos Santos, Daniel J.V.A.; Rosenthal, Philip J.; Moreira, Rui; European Journal of Medicinal Chemistry; vol. 80; (2014); p. 523 – 534;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

569-31-3,569-31-3, 6,7-Dimethoxy-3H-1-isobenzofuranone is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Isobenzofuran-1(3H)-one (0.4 mmol), KOH (0.4 mmol), PhSiH3 (1.2 mmol), dried THF (2 mL) were charged in a Schlenk tube(15 mL) under N2 atmosphere. The mixture was refluxed for 4 h. After cooling to rt, the reaction was quenched with EtOH(0.5-1 mL). Solvent was removed under reduced pressure and the crude residue was purified by column chromatography on silica gel with petroleum ether-ethyl acetate as the eluent to afford the desired product.

As the paragraph descriping shows that 569-31-3 is playing an increasingly important role.

Reference£º
Article; Liu, Bin; Zhou, Xigeng; Chinese Chemical Letters; vol. 30; 3; (2019); p. 725 – 728;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

52010-22-7, 4-Chlorophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,52010-22-7

(a) 3-bromo-4-chloroisobenzofuran-1(3H)-one (100) 4-chloroisobenzofuran-1(3H)-one (10 g, 59.32 mmol), (E)-2,2′-(diazene-1,2-diyl)bis(2-methylpropanenitrile) (0.974 g, 5.93 mmol) and 1-bromopyrrolidine-2,5-dione (11.61 g, 65.25 mmol) were dissolved CCl4 (100 mL) and heated at reflux for 2 hours. The reaction was cooled and filtered, the filtrate was evaporated to the desired compound as a yellow gum (14.20 g, 97% yield); 1H NMR (400.132 MHz, CDCl3) delta 7.32 (1H, s), 7.61 (1H, t), 7.73 (1H, d), 7.88 (1H, d); m/z (LC-MS, ESI+), RT=2.28 (M+H not detected).

52010-22-7 4-Chlorophthalide 3040300, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; MENEAR, Keith Allan; Javaid, Muhammad Hashim; Gomez, Sylvie; Hummersone, Marc Geoffrey; Lence, Carlos Fenandez; Martin, Niall Morrison Barr; Rudge, David Alan; Roberts, Craig Anthony; Blades, Kevin; US2009/192156; (2009); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57319-65-0, 6-Aminoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,57319-65-0

Example 16 3-(6-Amino-3H-isobenzofuran-1-ylidene)-5-chloro-1,3-dihydro-indol-2-one To a solution of 5-chlorooxindole (0.629 g, 3.78 mmol) in 10.0 mL monoglyme was added 7.51 mL sodium hexamethyldisilazane (1.0 M in THF) over 3 min. After stirring at room temperature for 8 min, a slurry of 6-aminophthalide (0.561 g, 3.78 mmol) in 4.0 mL of monoglyme was added in one portion. The mixture was stirred for 40 min and then quenched into 100 mL of 4% aqueous HCl solution. The yellow solid was filtered and then partitioned between EtOAc and saturated NaHCO3 (heated to dissolve the solid). The organic phase was washed with H2O, brine and then dried with Na2SO4. The solvent was removed in vacuo and the residue was triturated with MeOH to give the title compound (439 mg, 39%) as a yellow solid.

The synthetic route of 57319-65-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Allergan Sales, LLC; US6541504; (2003); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem