With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95333-17-8,Benzofuran-4-carbonitrile,as a common compound, the synthetic route is as follows.
In a 100 mL single-necked flask, benzofuran-4-carbonitrile C1-1e (1.1 g, 7.68 mmol), BOC anhydride (2.5 g, 11.52 mmol), methanol (50 mL), and 10% palladium carbon (2 g, containing 50 %water). The reaction mixture was purged with hydrogen for 5 minutes, vented three times with a hydrogen balloon, and stirred at 60 C. for 18 hours under a hydrogen balloon. The mixture was filtered through celite, washed with methanol (50 mL X 2), and the filtrate was concentrated under reduced pressure.Compound C1-1f (1.5 g, 79% yield) was obtained., 95333-17-8
Big data shows that 95333-17-8 is playing an increasingly important role.
Reference£º
Patent; Shanghai Qingyu Pharmaceutical Technology Co., Ltd.; Zou Bin; Ma Shichao; Wang Xiang; Zhang Zhongguo; (92 pag.)CN110563722; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem