With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37418-88-5,4-Hydroxyisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.
A mixture of 3-hydroxyphthalic anhydride(33.5mg, 0.2mmol), 3,5-bis(trifluoromethyl)benzyl amine(62mg, 0.2mmol) and chlorobenzene(5mL) was refluxed for 3 hours under argon atmosphere. After the reaction mixture was cooled to room temperature, the solvent was evaporated under reduced pressure and the obtained residue was crystallized n-hexane/ethyl acetate to give the title compound(68.5mg, 85.2percent) as a white crystal.1H-NMR(CDCl3): delta 4.90(2H, s), 7.19(1H, dd, J=8.4, 0.6Hz), 7.41(1H, dd, J=7.2, 0.6Hz), 7.61(1H, dd, J=8.4, 7.2Hz), 7.75(1H, brs), 7.82(1H, brs), 7.86(2H, s)., 37418-88-5
As the paragraph descriping shows that 37418-88-5 is playing an increasingly important role.
Reference£º
Patent; Institute of Medicinal Molecular Design, Inc.; EP1512396; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem