Category: benzofuran

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

652-39-1, A mixture of 3 -fluorophthalic anhydride (1 equiv.), 1 -amino-3 -(4-methoxybenzyl)-3 – azabicyclo[3.1.0]hexane-2,4-dione (1 equiv.), and potassium acetate (2.5 equiv.) in acetic acid is stirred at 120 ¡ãC overnight. The dark mixture is cooled and filtered. The filter cake is dissolved inDCM and washed with saturated NaHCO3 and brine. The organic layer is dried (Na2504) and concentrated to provide 4-fluoro adduct.To a solution of the resulting residue (1.0 equiv) in CH3CN, cooled to 0 ¡ãC, is added a solution of CAN (3.0 equiv) in H20, and the yellow clear solution is stirred at 0 ¡ãC for 2 h. Then it is diluted with EtOAc and quenched with half saturated aqueous NaC1 and diluted with EtOAcand H20. The phases are separated, and the aqueous phase is extracted with EtOAc (2 x) and CH2C12 (2 x). The combined organic phases are dried (Na2504), filtered, and concentrated in vacuo. The residue is purified by column chromatography on silica gel to provide 2-(2,4-dioxo-3- azabicyclo[3. 1. 0]hexan- 1 -yl)-4-fluoroisoindoline- 1,3 -dione. (Org. Lett. 2013, 15, 4312)

As the paragraph descriping shows that 652-39-1 is playing an increasingly important role.

Reference£º
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; FITZGERALD, Mark, E.; MICHAEL, Ryan, E.; (790 pag.)WO2017/197056; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

652-39-1, Combine the two ammonium salt mixtures from Example 1 (8.86 g, 1 eq), NaBH4 (8.37 g, 5 eq), and tetrahydrofuran (123 ml) into the reaction flask and allow the mixture to cool.A solution of BF3 in tetrahydrofuran (30.77 g, 5 eq) was added dropwise and incubated.After the addition was complete, the mixture was stirred and refluxed overnight. Methanol (30 ml) was added, 100 ml of water was added, and the pH was adjusted by adding hydrochloric acid and heating to 60¡ãC. After cooling, add water 300ml, extract with methyl tert-butyl ether, take the aqueous layer, adjust the pH with NaOH, extract with n-butanol, wash with water,It was evaporated to dryness to afford 6.30 g of a mixture of the compound of formula I-1 and the compound of formula I-2 in a yield of 92percent.

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Zhejiang Jiuzhou Pharmaceutical Technology Co., Ltd.; Shen Qirong; Yuan Xiangxiang; Gao Hongjun; Li Yuanqiang; (10 pag.)CN107915672; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

15832-09-4, 6-Methoxy-3(2H)-benzofuranone is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of benzofuran-3(2H)-one (2.0 mmol), benzaldehyde (2.2mmol) and water (5 mL) was stirred at reflux temperature for 6-10 h. Completion of the reaction was checked on TLC. Then the mixture was allowed to rt and stirred for 1 h. The precipitated solids were filtered, washedwith water (2 ¡Á 5 mL) and dried to give the product., 15832-09-4

The synthetic route of 15832-09-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Venkateswarlu, Somepalli; Murty, Gandrotu Narasimha; Satyanarayana, Meka; Arkivoc; vol. 2017; 4; (2017); p. 303 – 314;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

24410-59-1, 5-Fluorobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: At -78C, 1.2 mL (1.93 mmol) of a 1.6 M solution of n-butyllithium were slowly added to 175 mg (1.29 mmol) 5-fluorobenzofurane in 10 mL anhydroustetrahydrofurane. The mixture was stirred for 1 h at -78C. 0.52 mL (1.93 mmol) tri-n-buty[tinch[oride was added at -78C. The cooling bath was removed and stirring was continued for 72 h.Methanol was carefully added and the solvent evaporated. The obtained mixture was adsorbed on isolute and purified by flash chromatography. The obtainedmaterial (336 mg) was used directly in the subsequent step 2.Step 2: A mixture of 165 mg of the product from step 1, 100 mg (0.3 mmol) of intermediate 111.1 5, 10.5 mg (0.015 mmol) bis(triphenylphosphine)palladium(II) and 5.7 mg (0.03 mmol) copper(I)iodide in tetrahydrofurane were refluxed for 16 h.The reaction mixture was filtered through a of pad celite. The filtrate wasevaporated and the precipitate was dissolved in tetrahydrofurane. Insolublematerial was filtered off. The filtrate was evaporated and the obtained material was purified by HPLC and preparative thin layer chromatography to give 13 mg of the title compound as solid material., 24410-59-1

The synthetic route of 24410-59-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER INTELLECTUAL PROPERTY GMBH; EIS, Knut; PUeHLER, Florian; ZORN, Ludwig; SCHOLZ, Arne; LIENAU, Philip; GNOTH, Mark, Jean; BOeMER, Ulf; GUeNTHER, Judith; WO2013/41634; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

496-41-3, Benzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,496-41-3

Preparation 10; 2,3-Dihydro-1-benzofuran-2-carboxylic acidA mixture of 1-benzofuran-2-carboxylic acid (40.0 g, 250.0 mmol) and palladium hydroxide (20 wt. % on carbon, 2.0 g) in acetic acid (400 ml) was heated at 60 C. under a hydrogen atmosphere (80 psi) for 2 h. The mixture was filtered to give a solution of the title compound (39.5 g) in acetic acid.1H-NMR (d6-DMSO): 3.19-3.23 (1H), 3.50-3.54 (1H), 5.16-5.20 (1H), 6.78-6.82 (2H), 7.09-7.12 (1H), 7.18-7.20 (1H)

As the paragraph descriping shows that 496-41-3 is playing an increasingly important role.

Reference£º
Patent; PFIZER LIMITED; US2008/200540; (2008); A1;,
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Benzofuran | C8H6O – PubChem

7169-34-8, Benzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7169-34-8

General procedure: A mixture of 7-substituted 3(2H)-benzofuranones (7a and 7b) (1 eq), substituted aromatic aldehydes (8a-d)(1 eq), in ethanol (10 mL) were added 3 drops of piperidine. The mixture was then heated under reflux for 2 hours. After cooling H2O (20 mL) was added slowly. The crystalline precipitate was separated by filtration and purified by recrystallization from ethanol to afford pure compounds (9a-g).

The synthetic route of 7169-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Paidakula, Suresh; Nerella, Srinivas; Vadde, Ravinder; Kamal; Kankala, Shravankumar; Bioorganic and Medicinal Chemistry Letters; vol. 29; 16; (2019); p. 2153 – 2156;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84594-78-5,6-Nitro-2,3-dihydrobenzofuran-5-amine,as a common compound, the synthetic route is as follows.

84594-78-5, Isoamylnitrite (3 equiv) was added dropwise to a solution of 13 or 14(1 equiv) in anhydrous THF at 0C. The reaction mixture was stirred at 0C for 15 min and then refluxed for 3 h. The solution was cooled to room temperature, water (50 mL) was added, and the solution was extracted with ethyl acetate (350 mL). The organic layer was washed with brine, dried over MgSO4, then evaporated and purified by column chromatography with a gradient eluent of EA/n-hexane (2-8%) to give 15 (70%) as a yellow solid or 16 (74%) as a yellow solid.

84594-78-5 6-Nitro-2,3-dihydrobenzofuran-5-amine 13069187, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun; Bioorganic and Medicinal Chemistry; vol. 21; 13; (2013); p. 3821 – 3830;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

2.25 g of magnesium for a Grignard reaction in 15 ml of anhydrous THF are placed in a round-bottomed flask equipped with a mechanical stirrer, and under a stream of nitrogen.A mixture of 13.6 g of 5-bromobenzofuran in 35 ml of anhydrous THF is then added.The mixture is stirred for one hour, followed by addition of a solution of 5 g of 4,6-dichloro-1H-indole-2,3-dione in 50 ml of anhydrous THF.The mixture is stirred at room temperature for 4 hours 30 minutes.Water is added and the resulting mixture is extracted with ethyl acetate.The organic phase is separated out, dried over Na2SO4, filtered and evaporated under vacuum.The residue is taken up in ethyl acetate and washed with 1N sodium hydroxide solution.The organic phase is dried over Na2SO4, filtered and evaporated under vacuum.The solid is taken up in ethyl ether and filtered off. 4.2 g of expected product are obtained.TLC: 6/4 hexane/EtOAc, Rf=0.35, 23145-07-5

As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

Reference£º
Patent; SANOFI; US2012/40996; (2012); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

10035-16-2, Benzofuran-5-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step D; To a solution of aldehyde (400g) in ether (1 Oml) was added LiN (TMS) 2 (1 M in THF, 3. 3moi) at 0C dropwise. The solution was stirred at 0C for 30min and EtMgBr (3M in THF, 1. 83ml) was added dropwise. The reaction was refluxed overnight, cooed to 0C, quenched with saturated ammonium chloride and extracted with ether., 10035-16-2

10035-16-2 Benzofuran-5-carbaldehyde 2773875, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/66147; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24673-56-1,3-Methylbenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 185 5-Acetyl-3-methylbenzofuran-2-carboxylic acid Following the procedure of Example 155 but substituting 3-methylbenzofuran-2-carboxylic acid for ethyl 4-hydroxy-3-methylbenzofuran-2-carboxylate, the title compound was obtained. Analysis calc’d: C, 64.71; H, 3.95. Found: C, 65.06; H, 4.14., 24673-56-1

24673-56-1 3-Methylbenzofuran-2-carboxylic acid 600591, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Merck Frosst Canada, Inc.; US4663347; (1987); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem