Tag: 10035-16-2

10035-16-2, Benzofuran-5-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step D; To a solution of aldehyde (400g) in ether (1 Oml) was added LiN (TMS) 2 (1 M in THF, 3. 3moi) at 0C dropwise. The solution was stirred at 0C for 30min and EtMgBr (3M in THF, 1. 83ml) was added dropwise. The reaction was refluxed overnight, cooed to 0C, quenched with saturated ammonium chloride and extracted with ether., 10035-16-2

10035-16-2 Benzofuran-5-carbaldehyde 2773875, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/66147; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10035-16-2,Benzofuran-5-carbaldehyde,as a common compound, the synthetic route is as follows.

To a solution of aldehyde (400 g) in ether (10 ml) was added LiN(TMS)2 (1 M in THF, 3.3 ml) at 0 C. dropwise. The solution was stirred at 0 C. for 30 min and EtMgBr (3M in THF, 1.83 ml) was added dropwise. The reaction was refluxed overnight, cooed to 0 C., quenched with saturated ammonium chloride and extracted with ether. The ether was stirred with 3N HCl (20 ml), then the aqueous layer was basified with NaOH pellets and extracted with ether. The ether layer was washed with brine, dried with MgSO4, filtered and concentrated in vacuo to give 220 mg of product (46%).

The synthetic route of 10035-16-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Schering Corporation; US2004/106794; (2004); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem