Category: benzofuran

23145-07-5, 5-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weigh (950 mg, 4.82 mmol)Soluble12 mL anhydrous ether and cooled to -78 ¡ã C. 1.3 M tert-butyllithium in pentane (7.85 mL, 10.2 mmol) was added dropwise to the supernatant. The reaction was stirred at -78 ¡ã C for 2 hours,DMF (0.8 mL, 10.3 mmol) and diethyl ether (1 mL). After 1 h reaction, quench with ammonium chloride at -78 ¡ã C. Ethyl acetate extraction, anhydrous sulfur Sodium sulfate dried, concentrated, and passed through a silica gel column to give a yield of 75percent., 23145-07-5

23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Shanghai University; Xu Bin; Chen Cheng; (37 pag.)CN107266413; (2017); A;,
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4687-25-6,4687-25-6, Benzofuran-3-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A stirred mixture of heterocycle-carboxaldehyde 5(1.0 mmol) and p-toluene-sulfonylmethyl isocyanide (TosMIC)(1.1 mmol, 0.21 g) in 1:1 DME/MeOH (15 mL, both anhydrous) wasrefluxed with Ambersep 900(OH) ion exchange resin (2.0 g, exchangecapacity 1.18 meq/mL) for 2 h. The reaction mixture wasfiltered, the resin was washed by MeOH twice (2 5 mL), and thecombined filtrates were concentrated under reduced pressure togive the crude product, which was purified by column chromatography on silica gel (eluent: petroleum ether/acetone 4:1) to afford the pure compound 6.

The synthetic route of 4687-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Ming-Zhi; Jia, Chen-Yang; Gu, Yu-Cheng; Mulholland, Nick; Turner, Sarah; Beattie, David; Zhang, Wei-Hua; Yang, Guang-Fu; Clough, John; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 669 – 674;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58546-89-7,Benzofuran-5-amine,as a common compound, the synthetic route is as follows.

58546-89-7, A solution of Alloc-THP protected PBD-Py acid 14a (150 mg, 0.23 mmol, 1.0 equivalent) was dissolved in DMF. EDCI (0.46 mmol, 2.0 eq) and DMAP (0.58 mmol, 2.5 eq) were added to the stirred solution of 14a at room temperature and the mixture was allowed to stir for 30 minutes after which the benzofuran-5-amine (38.3 mg, 0.29 mmol, 1.25 eq) was added. The reaction mixture was allowed to stir for a further 3 hour at which point TLC showed completion of reaction. The reaction was quenched by pouring it onto a mixture of ice/water mixture and the resulting mixture was extracted with ethyl acetate (3 x 150 mL). The combined extracts were sequentially washed with citric acid (50 mL), saturated aqueous NaHC03 (50 mL), water (50 mL), brine (50 mL) and finally dried over MgS04. Excess ethyl acetate was evaporated by rotary evaporator under reduced pressure and the crude product was directly used in the next step without further purification. m/z (+EI) calc. for C4oH45N5010 (M)+ 755.91 found 756.76 ([M+H]+

As the paragraph descriping shows that 58546-89-7 is playing an increasingly important role.

Reference£º
Patent; UCL BUSINESS PLC; SPIROGEN SARL; HOWARD, Philip Wilson; THURSTON, David Edwin; RAHMAN, Khondaker Mirazur; TAYLOR, Peter William; WO2013/164592; (2013); A1;,
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41019-56-1, Methyl benzofuran-4-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of LiOH (1.44 g, 34.3 mmol) in water (20 mL) wasadded to a solution of the above ester (2.02 g, 11.4 mmol) in THF(20 mL) and MeOH (20 mL) and the solution was stirred at 20 Cfor 16 h and then evaporated. The residue was dissolved in water(50 mL) and acidified with conc. HCl and the precipitate was filteredand dried to give benzofuran-4-carboxylic acid (1.83 g,99%). 1H NMR (DMSO d6) d 13.10 (s, 1H), 8.14 (d, J = 2.1 Hz, 1H),7.85-7.91 (m, 2H), 7.43 (t, J = 7.9 Hz, 1H), 7.33 (dd, J = 2.1, 1.0 Hz,1H). Found: [MH] = 161.1.

41019-56-1, 41019-56-1 Methyl benzofuran-4-carboxylate 22326486, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Sutherland, Hamish S.; Tong, Amy S.T.; Choi, Peter J.; Conole, Daniel; Blaser, Adrian; Franzblau, Scott G.; Cooper, Christopher B.; Upton, Anna M.; Lotlikar, Manisha U.; Denny, William A.; Palmer, Brian D.; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1797 – 1809;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24673-56-1,3-Methylbenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a mixture of aniline (0.690 g, 7.41 mmol) in dichloromethane (25 mL), 3-methylbenzofuran-2-carboxylic acid (1c) (1.00 g, 5.7 mmol) was added with stirring. Then DMAP (0.116 g, 0.57 mmol) was added, followed by DCC (1.220 g, 5.9 mmol). The reaction was left to stir at room temperature for 23 h. The reaction mixture was then filtered and the filtrate washed with water (20 mL * 2), then 5% acetic acid (20 mL * 2) and again with water (20 mL * 2). The crude product was recrystallized from methanol to yield 2c as off-white crystals (0.896 g, 63%), mp 118-120 C. 1H NMR (300 MHz, CDCl3) delta 2.68 (s, 3H), 7.13-7.18 (t, J = 7.4 Hz, 1H), 7.30-7.52 (m, 5H), 7.62-7.65 (d, J = 7.57 Hz, 1H) 7.72-7.73 (d, J = 8.57 Hz, 2H), 8.35 (s, 1H). 13C NMR (300 MHz, CDCl3) delta 9.1, 111.6, 120.0, 121.1, 123.4, 123.9, 124.6, 127.5, 129.2, 129.9, 137.5, 142.4, 153.3, 158.1. MS(ESI)+ calcd for C16H14NO2 [M+H]+: 252.1025, found: 252.1027., 24673-56-1

As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.

Reference£º
Article; Marriott, Karla-Sue C.; Morrison, Andrew Z.; Moore, Misty; Olubajo, Olarongbe; Stewart, Leonard E.; Bioorganic and Medicinal Chemistry; vol. 20; 23; (2012); p. 6856 – 6861;,
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Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59434-19-4,4-Aminophthalide,as a common compound, the synthetic route is as follows.,59434-19-4

To a stirred mixture of 4-(trifluoromethyl)benzaldehyde (2.8 g, 16.1 mmol) and anhydrous Magnesium sulfate (16 g, 134 mmol) in anhydrous acetonitrile (200 mL) was added 4-aminoisobenzofuran-1(3H)-one (2 g, 13.4 mmol) at room temperature. After the addition, the mixture was stirred at reflux for overnight. The mixture was filtered and the cake was washed with ethyl acetate (50 mL¡Á3). The filtrate was concentrated to give crude product. The crude product was washed with petroleum ether and re-crystallized from ethyl acetate to give the title compound (2.8 g, yield: 68%). LC-MS (ESI) m/z: 306 (M+1)+

The synthetic route of 59434-19-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LEAD THERAPEUTICS, INC.; US2010/35883; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16859-59-9,3-Hydroxyisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

General procedure: 2-Formylbenzoic acid (1a; 1.0 equiv) and DMAP (0.1 equiv) were dis-solved in CH2Cl2 (0.15 M), producing a colorless clear solution. Thedesired carboxylic anhydride (2.0 equiv) and triethylamine (1.0equiv) were subsequently added and the reaction mixture was stirredat r.t. until complete conversion of the starting material was achieved(monitored by TLC). The solvent was removed under reduced pres-sure and the crude products were purified by column chromatogra-phy (n-hexane/EtOAc, 2:1)., 16859-59-9

16859-59-9 3-Hydroxyisobenzofuran-1(3H)-one 3804259, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Niedek, Dominik; Schuler, Soeren M.M.; Eschmann, Christian; Wende, Raffael C.; Seitz, Alexander; Keul, Felix; Schreiner, Peter R.; Synthesis; vol. 49; 2; (2017); p. 371 – 382;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1914-60-9,2,3-Dihydrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 188; l-rfU-Dihydrobenzofuran-l-carbonvD-aminol-indan-l-carboxylic acid acid ethyl ester(188):To a 4OmL vial containing a stirring bar, 2,3-dihydro-l-benzofuran-2-carboxylic acid (0.4g, 2.44mmol) is charged with dry DCM (7mL). Stirring is initiated. HBTU (922mg, 2.43mmol) and the DIPEA (0.95mL, 8.0mmol) are added. The 2-aminoindane-2-carboxylic acid ethyl ester (500mg, 2.44mmol) is added. The reaction is allowed to stir for 16h. Analysis by tic of the reaction mixture (silica, 10% MeOH/DCM) indicates complete consumption of the starting amine. The contents of the reaction flask are diluted with EtOAc (5OmL) and transferred to a separatory funnel. This is washed consecutively with dilute aqueous NaHCO3 (25mL) and brine (25mL), dried over MgSO4, filtered and evaporated in vacuo to provide 1.47g of viscous yellow oil. This material is dissolved in 1OmL of DCM and purified utilizing an ISCO Companion with a 4Og cartridge of silica. The gradient is 15 % EtOAc in heptanes for 3 column volumes followed by a linear gradient to 50% over 8 column volumes and then 90 % EtOAc for 2 column volumes with a ramp of 1 column volume. 25mL fractions are159 collected. Fractions 3 through 6 are combined and evaporated in vacuo. Pumping to a constant weight gives amorphous white solid 0.68g.

1914-60-9, The synthetic route of 1914-60-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANOFI-AVENTIS; WO2008/151211; (2008); A1;,
Benzofuran – Wikipedia
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90843-31-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90843-31-5,5-Acetyl-2,3-dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.

To a stirred solution of 1-(2,3-dihydrobenzofuran-5-yl)ethan-1-one (2.0 g, 13.0 mmol) in dry MeOH (20 mL), NaBH4 (0.68 g, 26.0 mmol, Loba chemie) was added slowly at 0 C. The reaction mixture was stirred at rt for 1 h. It was then concentrated under vacuum and the resulting crude product was dissolved in DCM (50 mL), washed with water, brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was used in the next step without further purification. Yield: 91 % (1.83 g).

As the paragraph descriping shows that 90843-31-5 is playing an increasingly important role.

Reference£º
Patent; ASCENEURON SA; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; (243 pag.)WO2016/30443; (2016); A1;,
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Benzofuran | C8H6O – PubChem

16859-59-9, 3-Hydroxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a suspension of magnesium (6.0 equiv) and catalytic amounts of I2 in anhydrous THF (12 mL) was added the appropriate 1-bromoalkane (5.0 equiv) under argon atmosphere until the Grignard reaction had started. After addition was completed, the reaction mixture was refluxed for 2 h and allowed to cool to room temperature. Subsequently, the prepared Grignard solution was added dropwise to a solution of 4 (300 mg, 1.998 mmol) at -5¡ãC. The resulting reaction mixture was stirred at room temperature for 5 h. The mixture was quenched with 3N HCl to pH=2 at 0¡ãC and stirred for another 1 h at room temperature. The solution was extracted with ethyl acetate (15 mL¡Á3). The combined organic layers were washed with 10percent K2CO3 aqueous solution (10 mL¡Á3) and brine (10 mL¡Á2), dried over anhydrous sodium sulfate, and evaporated under reduced pressure. The resulting residue was purified by column chromatography to give intermediates 5a-d as oils., 16859-59-9

The synthetic route of 16859-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Qiang, Xiaoming; Li, Yan; Yang, Xia; Luo, Li; Xu, Rui; Zheng, Yunxiaozhu; Cao, Zhongcheng; Tan, Zhenghuai; Deng, Yong; Bioorganic and Medicinal Chemistry Letters; vol. 27; 4; (2017); p. 718 – 722;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem