Category: benzofuran

143878-29-9, Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

25 g of intermediate (IV) was added to 140 mL of water and 27 mL of propylene glycol monomethyl ether, stirred,Add 20mL 50% sodium hydroxide solution, the system temperature to 90-100 , stirring temperature 12h,Stirring speed 300r / min, cooling to 0-10 , stirring 1h, filtered to obtain solid (intermediate sodium salt).The sodium salt of intermediate V was added to 200 mL of water and 40 mL of propylene glycol monomethyl ether and the temperature was raised to 75-85 C,Dropping 10mL concentrated hydrochloric acid, pH 1-2, precipitation of solid, cooling to 0-10 , stirring 1h,Stirring speed 300r / min, suction filtration, washing, drying at 50-60 for 8h to obtain intermediates (V)White solid, 13.2 g, yield 66%, purity 100.0% (HPLC)., 143878-29-9

143878-29-9 Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate 10635698, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Fuxin Fengcheng Chemical Technology Development Co., Ltd; Wang, Ji; Cao, Ronghao; (7 pag.)CN106316998; (2017); A;,
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Benzofuran | C8H6O – PubChem

42933-43-7, 2,3-Dihydrobenzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 5; Preparation of N-(4-tert-butylphenyl)-2,3-dihydro-1-benzofuran-5-amine; [Show Image] To a flask equipped with a magnetic stirrer, reflux condensor, and nitrogen inlet was added 2,3-dihydro-1-benzofuran-5-amine (11.6 grams, 85.8 mmoles, prepared as in Example 23 of U.S. Pat. No. 20040029932), 4-tert-butyl bromobenzene (18.1 grams, 85 mmoles), tris(dibenzylideneacetone)dipalladium (0) (1.6 grams, 1.7 mmoles), rac-2,2′-bis(diphenylphosphino)-1,1′-binapthyl (2.1 grams, 3.4 mmoles), sodium tert-butoxide (16.4 grams, 0.17 moles) and anhydrous toluene (100 mL). The contents of the flask were refluxed for three days; cooled to room temperature; and filtered through a pad of silica gel. The silica gel pad was then eluted with dichloromethane (150 mL). The combined organic layers were concentrated in vacuo to yield a dark solid. The solid was chromatographed on silica gel, eluting with hexane/ethyl acetate (20:1) to afford 10 grams of the desired product as a white solid. 1H NMR (CDCl3) delta 7.25 (d, 2H), 6.95 (s, 1H), 6.85 (d, 3H), 6.7 (d, 1H), 5.4 (bs, 1H), 4.5 (t, 2H), 3.15 (t, 2H), 1.3 (s, 9H)., 42933-43-7

As the paragraph descriping shows that 42933-43-7 is playing an increasingly important role.

Reference£º
Patent; Chevron Oronite Company LLC; EP1801104; (2007); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57319-65-0,6-Aminoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

57319-65-0, 6-Amino-1(3H)-isobenzofuranone (3.0 g, 20 mmol) obtained from Example 26-(1) was dissolved in a mixture of 47% aqueous hydrobromic acid solution (15 ml) and water (15 ml), then the mixture was cooled to 0C, and a solution of sodium nitrite (1.45 g, 21 mmol) in water (7 ml) was slowly added thereto. Further, a solution of copper (I) bromide (3.6 g, 25 mmol) dissolved in 47% aqueous hydrobromic acid solution (10 ml) was added to the reaction mixture, and the resulting mixture was stirred at 80C for 20 minutes. After cooling the mixture, the liberated product was collected by filtration and then washed with water. The obtained pale brown solid was dissolved in ethyl acetate, then the insoluble material was removed by filtration, and the filtrate was washed successively with a 1N aqueous solution of hydrochloric acid, an aqueous solution of sodium hydrogen carbonate, and an aqueous solution of sodium chloride, and then dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated to afford the title compound (3.57 g, 84% yield) as a crystalline solid. NMR spectrum (400 MHz, CDCl3) delta ppm: 5.289 (2H, s), 7.391 (1H, d, J=8 Hz), 7.808 (1H, dd, J=8, 2 Hz), 8.068 (1H, d, J=2 Hz) IR spectrum nu max KBr cm-1: 1778, 1458, 1359, 1191, 1046, 998, 768 Mass spectrum m/z (EI): 214, 212 (M+), 185, 183, 157, 155.

As the paragraph descriping shows that 57319-65-0 is playing an increasingly important role.

Reference£º
Patent; Sankyo Company, Limited; EP1362856; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

15832-09-4, 6-Methoxy-3(2H)-benzofuranone is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of compound 3a or 3b (2.0 mmol) in methanol (20 mL) was added successively anaqueous 50% potassium hydroxide (3 mL) and benzaldehyde derivatives 4 (3.0 mmol). The mixture was heated at 60 C and then solvent was evaporated. The residue was diluted in water and extracted with ethyl acetate. The organic layer was dried over anhydrous MgSO4 and filtered. The filtrate was concentrated and purified by silica gel column chromatography to give aurones., 15832-09-4

As the paragraph descriping shows that 15832-09-4 is playing an increasingly important role.

Reference£º
Article; Shin, Seo Young; Shin, Min Cheol; Shin, Ji-Sun; Lee, Kyung-Tae; Lee, Yong Sup; Bioorganic and Medicinal Chemistry Letters; vol. 21; 15; (2011); p. 4520 – 4523;,
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58546-89-7, Benzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

58546-89-7, Reference Example 1-14-(Benzofuran-5-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid ethyl ester hydrochloride To a solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid ethyl ester (0.383 g, 1.70 mmol) in isopropanol (15 ml) was added 5-aminobenzo[b]furan (0.250 g, 1.88 mmol), and the mixture was heated for 1 hour under reflux.After the completion of the reaction, the reaction mixture was cooled to 0 C., and then the precipitated solid was collected by filtration, washed with diethyl ether, and dried under reduced pressure to give the compound of the Reference Example 1-1 (0.528 g, 1.47 mmol, yield 87%).Mass (EI, m/z): 322 [M]+.1H-NMR (DMSO-d6) delta: 12.95 (1H, br s), 11.06 (1H, s), 8.39 (1H, s), 8.24 (1H, d, J=1.7 Hz), 8.15 (1H, s), 8.02 (1H, d, J=2.0 Hz), 7.65 (1H, d, J=8.8 Hz), 7.56 (1H, dd, J=8.8, 2.0 Hz), 7.02 (1H, d, J=1.7 Hz), 4.40 (2H, q, J=7.1 Hz), 1.37 (3H, t, J=7.1 Hz).

58546-89-7 Benzofuran-5-amine 1477152, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; UBE INDUSTRIES, LTD.; US2012/149902; (2012); A1;,
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13196-11-7, Benzofuran-6-ol is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a suspension of Example 5b (0.26 g, 1.9 mmol, 1 eq.), triethylamine (0.65 g, 6.5 mmol, 3.4 eq.), and magnesium dichloride (0.29 g, 3.1 mmol, 1.6 eq.) in acetonitrile (25 mL) was added paraformaldehyde (0.36 g, 13 mmol, 6.8 eq.) portionwise. The resulting mixture was refluxed for 3.5 hours at which time TLC revealed that all the starting material was consumed. The reaction mixture was acidified with 6 N HCl, concentrated and extracted with ether (3* 15 mL). The ether extracts were washed with water, brine, dried over Na2S04 and concentrated under reduced pressure to give the desired product (Example 5c, 0.22 g, crude yield 65%) as yellow oil., 13196-11-7

13196-11-7 Benzofuran-6-ol 128844, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (212 pag.)WO2017/218960; (2017); A1;,
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79002-39-4, Benzofuran-5-carbonitrile is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,79002-39-4

EXAMPLE 15:PREPARATION OF 5-(5-FORMYL-I -BENZOFURAN-2-YL)-6-METHYL-4-[(4- METHYL-1 H-INDOL-5-YL)AMINO]NICOTINONITRILEStep a): Preparation of 5-formylbenzofuran.To a -150C to -2O0C solution of 1-benzofuran-5-carbonitrile (5 g, 34.9 mmol) in 50 mL of dichloromethane under nitrogen was added DIBAL-H (41.9 mL, 41.9 mmol, 1.0M in heptane) such that the temperature was less than or equal to -150C. The reaction mixture was stirred for an additional 10 min at -150C to -2O0C and quenched by adding 2.0 N HCI dropwise such that the temperature was less than or equal to room temperature. The organic layer was then separated, washed with water, dried over sodium sulfate and concentrated to give 4 g (78%) of the title compound as a yellow oil, which was used in the next step without further purification.

79002-39-4 Benzofuran-5-carbonitrile 2795184, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; WYETH; WO2009/76571; (2009); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23681-89-2,2,3-Dihydrobenzofuran-6-ol,as a common compound, the synthetic route is as follows.

EXAMPLE 7 275 mg. of a 55percent sodium hydride dispersion in oil are washed under nitrogen three times with absolute tetrahydrofuran and then covered with 5 ml. of absolute tetrahydrofuran. Thereafter, the mixture is cooled to 0¡ã C. and treated dropwise while stirring with a solution of 0.85 g. of 6-hydroxy-2,3-dihydrobenzofuran in 10 ml. of absolute tetrahydrofuran. The mixture is stirred for one hour at room temperature, again cooled to 0¡ã C. and 1.22 g. of 1-bromo-3,7,7-trimethyl-2,4-octadiene dissolved in 10 ml. of absolute tetrahydrofuran are added. Subsequently, the mixture is diluted with 10 ml. of absolute hexamethylphosphoric acid triamide, the ice bath removed and the mixture stirred for 2 hours. Thereafter, the mixture is poured onto ice-water and extracted three times with diethyl ether. The extracts are washed with water and saturated aqueous sodium chloride solution, dried over sodium sulfate and evaporated. By chromatography on silica gel with hexane/diethyl ether (98:2 parts by volume) there is obtained pure 6-[(3,7,7-trimethyl-2,4 -octadienyl)-oxy]-2,3-dihydrobenzofuran which is distilled in a bulb-tube at 130¡ã C./0.02 mmHg; nD20 = 1.5438.

23681-89-2, The synthetic route of 23681-89-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hoffmann-La Roche Inc.; US4002647; (1977); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1914-60-9,2,3-Dihydrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 7 (1 eq) and 1,1?-carbodiimidazole (1.2 eq) in anhydrous THF was stirred for 1h then substituted aniline (0.9 eq) was added at room temperature. After stirring for 14 h, solvent was evaporated then the mixture acidified with 6N HCl to pH 2. The mixture was extracted with EtOAc (3 ¡Á 20 mL). The combined extracts were dried over anhydrous Na2SO4and the solvent was evaporated. After evaporation, the residue was purified by column chromatography (EtOAc/hexane = 1:3 – 1:50)., 1914-60-9

As the paragraph descriping shows that 1914-60-9 is playing an increasingly important role.

Reference£º
Article; Choi, Minho; Jo, Hyeju; Park, Hyun-Jung; Sateesh Kumar, Arepalli; Lee, Joonkwang; Yun, Jieun; Kim, Youngsoo; Han, Sang-Bae; Jung, Jae-Kyung; Cho, Jungsook; Lee, Kiho; Kwak, Jae-Hwan; Lee, Heesoon; Bioorganic and Medicinal Chemistry Letters; vol. 25; 12; (2015); p. 2545 – 2549;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7169-34-8,Benzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.

7169-34-8, General procedure: Coumaranone (1.00 mmol) and aldehyde (1.00 mmol) were combined in a dry vial. 3.5 g of neutral alumina was then added followed by 5 mL of dichloromethane. The reaction mixture was stirred for 12 h at 25 C. The reaction mixture was then filtered and the dichloromethane layer collected and concentrated to dryness in vacuo to afford the desired aurone. Further purification was performed as noted.

The synthetic route of 7169-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sutton, Caleb L.; Taylor, Zachary E.; Farone, Mary B.; Handy, Scott T.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 4; (2017); p. 901 – 903;,
Benzofuran – Wikipedia
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