Downstream synthetic route of 13196-11-7

13196-11-7 Benzofuran-6-ol 128844, abenzofuran compound, is more and more widely used in various fields.

13196-11-7, Benzofuran-6-ol is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a suspension of Example 5b (0.26 g, 1.9 mmol, 1 eq.), triethylamine (0.65 g, 6.5 mmol, 3.4 eq.), and magnesium dichloride (0.29 g, 3.1 mmol, 1.6 eq.) in acetonitrile (25 mL) was added paraformaldehyde (0.36 g, 13 mmol, 6.8 eq.) portionwise. The resulting mixture was refluxed for 3.5 hours at which time TLC revealed that all the starting material was consumed. The reaction mixture was acidified with 6 N HCl, concentrated and extracted with ether (3* 15 mL). The ether extracts were washed with water, brine, dried over Na2S04 and concentrated under reduced pressure to give the desired product (Example 5c, 0.22 g, crude yield 65%) as yellow oil., 13196-11-7

13196-11-7 Benzofuran-6-ol 128844, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (212 pag.)WO2017/218960; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem