Day: February 22, 2023

Cell-Penetrating Homochiral Cyclic Peptides as Nuclear-Targeting Molecular Transporters was written by Mandal, Deendayal;Shirazi, Amir Nasrolahi;Parang, Keykavous. And the article was included in Angewandte Chemie, International Edition in 2011.Electric Literature of C19H30N4O5S This article mentions the following:

The authors report the design and evaluation of amphipathic homochiral L-cyclic peptides for potential applications as cell-penetrating peptides or mol. transporters of bioactive compounds To examine the potential application of the cyclic peptides as mol. transporters, a model experiment was performed with lamivudine. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2Electric Literature of C19H30N4O5S).

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Electric Literature of C19H30N4O5S

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Tolerability of mycophenolate mofetil in elderly kidney transplant recipients: A retrospective cohort study was written by Witek, Stephanie;Malat, Gregory;Sawinski, Deirdre;Sammons, Chelsea;LaFratte, Christopher;Forte, Abigail;Samudralwar, Rahul;Lyle, Sandra;Rashid, Jamal;Trofe-Clark, Jennifer. And the article was included in Clinical Transplantation in 2022.Name: (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid This article mentions the following:

Optimal immunosuppression in elderly kidney transplant recipients (KTRs) is not well defined, with mycophenolate mofetil (MMF) being poorly tolerated. Study aim was to compare MMF dose reduction incidence and reason(s) in elderly vs. nonelderly KTRs in the 1st year after transplant with a protocol dose of 1 g/day. In this single-center retrospective study, first or repeat KTRs receiving rabbit antithymocyte globulin (rATG), MMF 1 g/day, tacrolimus, and prednisone, were stratified by age [≥60 (elderly) or <60 years (nonelderly)]. Primary outcome was MMF dose reduction incidence in the first year. Secondary outcomes included dose reduction rationale, 1-yr patient and graft survival, graft function, rejection, infection, hospital presentation, and time to dose reduction Of 335 KTRs, dose reduction incidence was significantly greater in the elderly group (66% and 54%, p = 0.04), though this did not remain significant when adjusted for sex, race, and valganciclovir use. Most common rationale was leukopenia in the elderly group and CMV in the nonelderly group. There were no significant differences in secondary outcomes. Mycophenolate mofetil 1 g/day was poorly tolerated in both elderly and nonelderly KTRs receiving lymphocyte-depleting induction with a high incidence of dose reductions; however, no short-term adverse graft outcomes were identified. In the experiment, the researchers used many compounds, for example, (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1Name: (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid).

(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Name: (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Kinetics of the opening and closing of lactone rings. Structural influence. II. Study on ortho substituted phthalides. Application of the Hammett equation was written by Vene, J.;Tirouflet, J.. And the article was included in Bulletin de la Societe Chimique de France in 1954.Name: 5-Methoxyisobenzofuran-1(3H)-one This article mentions the following:

Rate constants, energies of activation and entropy factors for the alk. hydrolysis of phthalides, substituted in the position ortho to the carboxyl were determined The results are analyzed considering the Hammett equation and the latter is found to be applicable to this case. Stearic factors enter into the reaction as they do in the case of the benzoates. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2Name: 5-Methoxyisobenzofuran-1(3H)-one).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Name: 5-Methoxyisobenzofuran-1(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chiral precursors for syntheses of furanoterpenes was written by Marco, Jose L.. And the article was included in Tetrahedron in 1989.Category: benzofurans This article mentions the following:

The synthesis of (2S,4R,5R)- and (2R,4R,5R)-2-(3-furyl)-4,5-isopropylidenedioxytetrahydrofuran (I) and (2S,4R,5S)-5-ethoxy-2-(3-furyl)-4-hydroxytetrahydrofuran (II) from “diacetone glucose” (III) is described. A new approach to 1-(R) and 1-(S)-(3-furyl)-1,2-dihydroxyethane (IV) from L-serine and D-mannitol, resp., is described. These compounds are convenient chiral precursors for syntheses of furanoterpenes. In the experiment, the researchers used many compounds, for example, (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0Category: benzofurans).

(3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Semiquantitative naked-eye detection of synthetic food colorants using highly-branched pipette tip as an all-in-one device was written by Wang, Shuangshou;Li, Wenzhi;Yuan, Zhihong;Jin, Qiwen;Ding, Zongpeng;Liu, Xiaomeng;Ye, Mingfu;Gu, Jing;Yan, Tingxuan;Chen, Hongmei;Chen, Yang. And the article was included in Analytica Chimica Acta in 2022.SDS of cas: 16423-68-0 This article mentions the following:

The existing strategies for the determination of synthetic food colorants (FCs) in manufactured foods are highly relied on specialized instruments and skilled personnel which are limited by the high tech. threshold and instrumentation cost. Herein, highly branched pipet tips (PTs) were fabricated as a robust all-in-one device for high-performance extraction and visual detection of FCs via handy aspiration and dispensing procedures of pipet controller. The d. of extraction groups and inner sp. surface area of PTs greatly increased after facile phys. coating and subsequent layer-by-layer branching reactions, and the maximum increment in binding capacity of PTs was exceeded 300 times at 8-10 iterations of branching layers, enabling the PTs to be colored just by short-time extraction of FCs and to achieve the instrument-independent visual detection of FCs by virtue of their outstanding PT-SPE performance. As a proof-of-concept, the in-situ PT-based solid phase extraction (PT-SPE) with high recoveries (from 91.73 ± 4.76% to 99.90 ± 4.14%) and semiquant. naked-eye detection of FCs (Allura red and brilliant blue) in real beverages were exptl. demonstrated to be highly feasible by comparison with classical techniques like spectrophotometry, HPLC, and mass spectrometry. In the experiment, the researchers used many compounds, for example, Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0SDS of cas: 16423-68-0).

Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.SDS of cas: 16423-68-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1 was written by Kallander, Lara S.;Washburn, David;Hilfiker, Mark A.;Eidam, Hilary Schenck;Lawhorn, Brian G.;Prendergast, Joanne;Fox, Ryan;Dowdell, Sarah;Manns, Sharada;Hoang, Tram;Zhao, Steve;Ye, Guosen;Hammond, Marlys;Holt, Dennis A.;Roethke, Theresa;Hong, Xuan;Reid, Robert A.;Gampe, Robert;Zhang, Hong;Diaz, Elsie;Rendina, Alan R.;Quinn, Amy M.;Willette, Bob. And the article was included in ACS Medicinal Chemistry Letters in 2018.Safety of 7-Methoxybenzofuran-2-carboxylic acid This article mentions the following:

Bone Morphogenetic Protein 1 (BMP1) inhibition is a potential method for treating fibrosis because BMP1, a member of the zinc metalloprotease family, is required to convert pro-collagen to collagen. A novel class of reverse hydroxamate BMP1 inhibitors was discovered, and cocrystal structures with BMP1 were obtained. The observed binding mode is unique in that the small mol. occupies the nonprime side of the metalloprotease pocket providing an opportunity to build in metalloprotease selectivity. Structure-guided modification of the initial hit led to the identification of an oral in vivo tool compound with selectivity over other metalloproteases. Due to irreversible inhibition of cytochrome P 450 3A4 for this chem. class, the risk of potential drug-drug interactions was managed by optimizing the series for s.c. injection. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8Safety of 7-Methoxybenzofuran-2-carboxylic acid).

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Safety of 7-Methoxybenzofuran-2-carboxylic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Enantioselective addition of arylboronic acids to methyl 2-formylbenzoates by using a ruthenium/Me-BIPAM catalyst for synthesis of chiral 3-aryl-isobenzofuranones was written by Yohda, Masaaki;Yamamoto, Yasunori. And the article was included in Organic & Biomolecular Chemistry in 2015.Recommanded Product: 54120-64-8 This article mentions the following:

A series of chiral 3-aryl-isobenzofuranones I (R = 5-CF₃, 6-Br, 7-CH₃, etc.; Ar = Ph, 2-naphthyl, 3-thienyl, etc.) were synthesized via ruthenium/Me-BIPAM-catalyzed asym. addition of arylboronic acids ArB(OH)₂ to Me 2-formylbenzoates R¹C(O)H [R¹ = 2-C(O)OCH₃-C₆H₄, 2-C(O)OCH₃-5-CF₃-C₆H₃, 2-C(O)OCH₃-4-Cl-C₆H₃, etc.]. The [RuCl₂ (p-cymene)]₂/Me-BIPAM and RuCl₂(PPh₃)₃/Me-BIPAM catalyst systems tolerate a variety of functional groups and give high yields with high enantioselectivities. In the experiment, the researchers used many compounds, for example, 5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8Recommanded Product: 54120-64-8).

5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Recommanded Product: 54120-64-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Carbene-Catalyzed Three-Component Cascade Reaction of Benzofuran-2-ones and Enals: Construction of Spirobenzofuranone-δ-lactones was written by Wang, Zhan-Yong;Shen, Fumin;Yang, Ting;Zhang, Jun-Kai;Chen, Rongxiang;Wang, Kai-Kai;Liu, Hongxin. And the article was included in Asian Journal of Organic Chemistry in 2021.Safety of 5-Nitrobenzofuran-2(3H)-one This article mentions the following:

A convenient method was developed via an NHC mediated three-component cascade reaction for the construction of medicinally important spirobenzofuranone derivatives such as I [R¹ = H, Br, NO₂; R² = Ph, 2-furyl, 1-naphthyl, etc.]. The reaction features mild reaction conditions and generates three consecutive stereocenters, one of which is an all-carbon substitution. The protocol can accommodate various substituents and substitution patterns, afford the products in moderate to good yields with excellent diastereoselectivities and moderate enantioselectivity. In the experiment, the researchers used many compounds, for example, 5-Nitrobenzofuran-2(3H)-one (cas: 21997-23-9Safety of 5-Nitrobenzofuran-2(3H)-one).

5-Nitrobenzofuran-2(3H)-one (cas: 21997-23-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Safety of 5-Nitrobenzofuran-2(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Allelopathy of welsh onion root exudates on cucumber seed germination and Fusarium oxysporum f. sp. cucumerinum and GC-MS analysis was written by Xu, Ning;Wang, Chao;Wei, Min;Shi, Wei;Wang, Xiu-feng. And the article was included in Yuanyi Xuebao in 2012.HPLC of Formula: 1563-38-8 This article mentions the following:

The allelopathy of welsh onion root exudates collected by continuous root exudates trapping system (CRETS) was studied on cucumber seed germination and Fusarium oxysporum f. sp. cucumerinum, and the components of the root exudates were identified by gas chromatog.-mass spectrometry (GS-MS). The results showed that the seed germination and sprout growth of cucumber were promoted by root exudates of welsh onion at low concentration while suppressed at high concentration, the allelopathy of ‘Yuanzang’ was stronger than ‘Zhangqiu’. Inhibitory effects on hypha growth and spore germination of Fusarium oxysporum f. sp. cucumerinum enhanced with increasing concentration of root exudates, and ‘Yuanzang’ showed stronger effects than ‘Zhangqiu’. Heterocyclic, ester, amide, acid, hydrocarbon, aldehyde, ketone, phenol, alc., ether, naphthalene compounds were detected in root exudates of Welsh onion, of which heterocyclic, ester and amide were the most compounds Phthalate esters and benzothiazole derivatives had greater relative contents while p-cresol 2,2′-methylenebis 6-tert-butyl-, benzyl benzoate, benzoic acid p-tolyl ester, 2-(methylthio) Ph isothiocyanate had lower relative contents, which were higher in ‘Yuanzang’ than in ‘Zhangqiu’. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8HPLC of Formula: 1563-38-8).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.HPLC of Formula: 1563-38-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Syntheses of substituted phthalides and substituted phthalic anhydrides and a study of the reactivity of the carbonyl group. III. Kinetic study of the alkaline hydrolysis of substituted phthalides. 1. Alkaline hydrolysis of phthalides was written by Tirouflet, Jean. And the article was included in Bull. soc sci. Bretagne Spec. in 1951.COA of Formula: C9H8O3 This article mentions the following:

The rate constants for the alk. hydrolysis of many substituted phthalides have been determined at 25.0° in 15.1 weight-% EtOH in CO₂-free water by titrating the excess NaOH with 0.01N H₂SO₄ and phenolphthalein; 0.0005 mole of the substituted phthalide was used in 250 cc. solution, although check runs with 0.02 and 0.008 mole showed no significant change. The solutions of the phthalides were tested after hydrolysis with AgNO₃ solution, but no secondary reactions involving halogen displacements were found. Similarly, no hydrolysis of AcNH groups occurred, as shown by quant. recovery of AcNH-substituted acid alcs. after hydrolysis. The following average rate constants were obtained for the phthalides [substituent, K (min.^-1 mole/liter^-1)]: H, 11.7; 4-NH₂, 8.75; 5-NH₂, 0.47; 6-NH₂, 6.7; 7-NH₂, 0.60; 4-AcNH, 28.8; 5-AcNH, 7.6; 6-AcNH, 21.3; 7-AcNH, 13.3; 4-MeO, 17.6; 5-MeO, 2.5; 6-MeO, 13.65; 6,7-(MeO)₂, 7.9; 4-EtO 19.4 (estimated value because of precipitation of supersaturated phthalide solution prior to complete reaction); 5-EtO, 2.58; 6-EtO, 11.9; 4-O₂N, 184; 5-O₂N, 398; 6-O₂N, 246; 5-NC, 275; 6-NC, 161; 4-Cl, 54.3; 5-Cl, 25.2; 6-Cl, 47.6; 7-Cl, 50.3; 4-Br, 50.6; 5-Br, 27.0; 6-Br, 48.4; 7-Br, 43.4; 4-I, 47.1; 5-I, 30; 6-I, 49.1; 7-I, 32.1; 3-Me, 6.5; 3,4-Me(H₂N), 3.3. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2COA of Formula: C9H8O3).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.COA of Formula: C9H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem