Carbene-Catalyzed Three-Component Cascade Reaction of Benzofuran-2-ones and Enals: Construction of Spirobenzofuranone-δ-lactones was written by Wang, Zhan-Yong;Shen, Fumin;Yang, Ting;Zhang, Jun-Kai;Chen, Rongxiang;Wang, Kai-Kai;Liu, Hongxin. And the article was included in Asian Journal of Organic Chemistry in 2021.Safety of 5-Nitrobenzofuran-2(3H)-one This article mentions the following:
A convenient method was developed via an NHC mediated three-component cascade reaction for the construction of medicinally important spirobenzofuranone derivatives such as I [R1 = H, Br, NO2; R2 = Ph, 2-furyl, 1-naphthyl, etc.]. The reaction features mild reaction conditions and generates three consecutive stereocenters, one of which is an all-carbon substitution. The protocol can accommodate various substituents and substitution patterns, afford the products in moderate to good yields with excellent diastereoselectivities and moderate enantioselectivity. In the experiment, the researchers used many compounds, for example, 5-Nitrobenzofuran-2(3H)-one (cas: 21997-23-9Safety of 5-Nitrobenzofuran-2(3H)-one).
5-Nitrobenzofuran-2(3H)-one (cas: 21997-23-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Safety of 5-Nitrobenzofuran-2(3H)-one
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem