Enantioselective addition of arylboronic acids to methyl 2-formylbenzoates by using a ruthenium/Me-BIPAM catalyst for synthesis of chiral 3-aryl-isobenzofuranones was written by Yohda, Masaaki;Yamamoto, Yasunori. And the article was included in Organic & Biomolecular Chemistry in 2015.Recommanded Product: 54120-64-8 This article mentions the following:
A series of chiral 3-aryl-isobenzofuranones I (R = 5-CF3, 6-Br, 7-CH3, etc.; Ar = Ph, 2-naphthyl, 3-thienyl, etc.) were synthesized via ruthenium/Me-BIPAM-catalyzed asym. addition of arylboronic acids ArB(OH)2 to Me 2-formylbenzoates R1C(O)H [R1 = 2-C(O)OCH3-C6H4, 2-C(O)OCH3-5-CF3-C6H3, 2-C(O)OCH3-4-Cl-C6H3, etc.]. The [RuCl2 (p-cymene)]2/Me-BIPAM and RuCl2(PPh3)3/Me-BIPAM catalyst systems tolerate a variety of functional groups and give high yields with high enantioselectivities. In the experiment, the researchers used many compounds, for example, 5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8Recommanded Product: 54120-64-8).
5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Recommanded Product: 54120-64-8
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem