Kallander, Lara S. et al. published their research in ACS Medicinal Chemistry Letters in 2018 | CAS: 4790-79-8

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Safety of 7-Methoxybenzofuran-2-carboxylic acid

Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1 was written by Kallander, Lara S.;Washburn, David;Hilfiker, Mark A.;Eidam, Hilary Schenck;Lawhorn, Brian G.;Prendergast, Joanne;Fox, Ryan;Dowdell, Sarah;Manns, Sharada;Hoang, Tram;Zhao, Steve;Ye, Guosen;Hammond, Marlys;Holt, Dennis A.;Roethke, Theresa;Hong, Xuan;Reid, Robert A.;Gampe, Robert;Zhang, Hong;Diaz, Elsie;Rendina, Alan R.;Quinn, Amy M.;Willette, Bob. And the article was included in ACS Medicinal Chemistry Letters in 2018.Safety of 7-Methoxybenzofuran-2-carboxylic acid This article mentions the following:

Bone Morphogenetic Protein 1 (BMP1) inhibition is a potential method for treating fibrosis because BMP1, a member of the zinc metalloprotease family, is required to convert pro-collagen to collagen. A novel class of reverse hydroxamate BMP1 inhibitors was discovered, and cocrystal structures with BMP1 were obtained. The observed binding mode is unique in that the small mol. occupies the nonprime side of the metalloprotease pocket providing an opportunity to build in metalloprotease selectivity. Structure-guided modification of the initial hit led to the identification of an oral in vivo tool compound with selectivity over other metalloproteases. Due to irreversible inhibition of cytochrome P 450 3A4 for this chem. class, the risk of potential drug-drug interactions was managed by optimizing the series for s.c. injection. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8Safety of 7-Methoxybenzofuran-2-carboxylic acid).

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Safety of 7-Methoxybenzofuran-2-carboxylic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem