Effect of different structures fabricated by additive manufacturing on bone ingrowth was written by Lu, Shunyi;Jiang, Dongjie;Liu, Shuhao;Liang, Haifeng;Lu, Junren;Xu, Hao;Li, Juan;Xiao, Jian;Zhang, Jian;Fei, Qinming. And the article was included in Journal of Biomaterials Applications in 2022.Category: benzofurans This article mentions the following:
To study the effects of different structures (solid/hollow) and pore diameters (300/600μm) on bone ingrowth. Porous titanium alloy scaffolds (3.2*10.5 mm) were printed using electron beam melting. The implants were divided into either Hollow or Solid Group. The upper half of each implant was printed with a pore diameter of 600μm while the bottom half was printed with a pore diameter μof 300 m. Visualization of the structural morphol. was done using Scanning Electron Microscope (SEM). Cell proliferation was evaluated with the cell counting kit-8 assay and live/dead staining assay. The different lateral femoral condyles of 15 New Zealand rabbits were implanted with different groups of scaffolds. The rabbits were randomly sacrificed at the 4th, 8th, and 12th week postoperatively. Bone mineral d. (BMD) and bone volume fraction (BV/TV) evaluation was completed by quant. Micro-Computed Tomog. (Micro-CT). Tissue histol. were stained with toluidine blue to observe bone ingrowth under an optical microscope, and the percentage of new bone area were calculated using Image Pro-Plus 6.0. SEM images showed a significant decrease in residual powder in the hollow implant and cell studies showed no obvious cytotoxicity for the Ti6Al4V scaffolds. Micro-CT reconstruction revealed high levels of new bone formation around the scaffolds. The trabeculae around the implants showed a gradual increase with each week, and new bone filled the scaffold pores gradually. BMD, BV/TV, and tissue histol. revealed the 300μm pore diameter is more conducive to bone ingrowth than the 600μm (p <.05). Our study revealed that Ti6Al4V implants with hollow structure could reduce the residual metal powder and implants with 300μm pore diameter were more effective on bone formation than a 600μm. In the experiment, the researchers used many compounds, for example, 2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0Category: benzofurans).
2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Category: benzofurans
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem